A5067036364- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Platelet Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
Dong-A University
2013-2023
Dong-A University Hospital
2007-2022
Busan Medical Center
2020
The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis to malignancy. Because C-reactive protein (CRP) a representative marker for inflammation, CRP has recently been associated with progression disease in many cancer types. principal objective this study was determine preoperative serum levels IL-6 gastric carcinoma, correlate them status prognosis. A total 115 patients who underwent gastrectomy were enrolled study. Serum assessed via Enzyme-Linked...
Summary Background Tegoprazan is a novel potassium‐competitive acid blocker for the treatment of acid‐related disorders. Aims To assess whether tegoprazan non‐inferior to lansoprazole in terms efficacy and safety patients with gastric ulcers. Methods In this phase 3, double‐blind, active control, multicentre study, 306 ulcer were randomised one three groups: 50 mg, 100 mg 30 once daily 4 or 8 weeks. The primary endpoint was cumulative proportion healed ulcers confirmed by endoscopy up weeks...
Abstract Background Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, vascular endothelial (VEGF) are all important factors in the mechanisms inherent to progression. In this work, we have investigated clinicopathologic significance of HIF-1α, VEGF expression preoperative serum (sVEGF) level gastric cancer. We immunohistochemically assessed patterns 114 specimens Additionally, determined levels (sVEGF). Results The...
Abstract Aim: Adjuvant chemoradiation has become a standard of care in the USA. We evaluated efficacy and toxicity adjuvant versus chemotherapy completely resected locally advanced gastric cancer. Methods: Patients with stage IIIA, IIIB IV (without metastasis) cancer were treated 5‐fluorouracil/cisplatin (FP) (arm A) or FP B). Arm A consisted one cycle followed by 4500 cGY to radiation field capecitabine. One month after completion radiotherapy, patients received three additional cycles...
Endoscopic resection is commonly used for early gastric cancer (EGC) in Korea and Japan. There are only a few reports of metachronous after endoscopic resection. The aim this study was to identify clinical factors associated with resection.A total 176 patients EGC who had underwent submucosal dissection (ESD) were periodically followed-up examinations from January 2004 December 2007. incidence variable investigated retrospective study.The median interval between the diagnosis primary first...
Gwang Ha Kim, Myung-Gyu Choi, Jin Il Soo Teik Lee, Hoon Jai Chun, Kook Lae Suk Chei Jae-Young Jang, Yong Chan Jae Gyu Ki Bae Ki-Nam Shim, Chong Sohn, Sung Sang Gyun Seok Nayoung Hwoon-Yong Jung, Hyojin Park, Kyu Huh, Kwang Su Hong, Song Baek, Joo Han, and Oh Young Lee. Gut Liver -0001;0:. https://doi.org/10.5009/gnl220457
Jin Seok Janga, Reyol Choi*a, Waqar Qureshib, Min Chan Kimc, Su Kimd, Sook Jeungd, Sang Young Hana, Myung Hwan Noha, Jong Hoon Leea, Seung Wook Yang Hyun Baeka, Sung Kima & Phil Jo Choiea Department of Internal Medicine, Dong-A Medical Center, University College Busan, South Koreab Michael E. DeBakey Veterans Affairs Center and Baylor Houston, Texas, USAc General Surgeryd Pathologye Cardiac Surgery, Korea
The aim of this study is to assess serum procalcitonin (PCT) for early prediction severe acute pancreatitis compared with multiple scoring systems and biomarkers.Forty-four patients confirmed by radiological evidences, laboratory assessments, clinical manifestation were prospectively enrolled. All blood samples image studies obtained within 24 hours admission.Acute was graded as in 19 mild 25 according the Atlanta criteria. Levels PCT significantly higher (p=0.001). accuracy a predicting...
Background/Aims The bedside index of severity in acute pancreatitis (BISAP) is a new, convenient, prognostic multifactorial scoring system. As more data are needed before clinical application, we compared BISAP, the serum procalcitonin (PCT), and other systems simultaneously. Methods Fifty consecutive patients were enrolled prospectively. Blood samples obtained at admission after 48 hours imaging studies performed within admission. BISAP score was with PCT, Ranson's score, physiology chronic...
Objective. Endoscopic submucosal dissection (ESD) of gastric neoplasia has been reported to have a higher bleeding rate than conventional endoscopic mucosal resection (EMR). The aim this study was identify the risk factors for associated with ESD. Material and methods. records consecutive patients who underwent ESD adenoma/early cancer were reviewed. Potential included patient age, lesion size, gross findings, location, histology tumor. primary end-point incidence immediate or delayed...
The objective of this study was to determine whether the expressions excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase P1 (GSTP1) are predictive clinical outcomes in advanced gastric cancer (AGC) patients receiving treatment with adjuvant 5-fluorouracil (5-FU) cisplatin (FP) chemotherapy. One hundred forty nine were included study. ERCC1 GSTP1 expression correlated significantly tumor size (p = 0.040, p 0.018, respectively). Stage positive lymph...
Fascin is an actin‐binding protein that provides mechanical support and cell motility, involves cancer metastasis. We investigated fascin expression in gastric assessed their relationship with clinicopathologic parameters survival rates. In addition, we researched galectin‐3 to study action mechanisms. performed immunohistochemisty antibodies 471 carcinomas, using tissue microarrays. was positive 14.9% (70/471) of the samples, related worse rates ( P < 0.001), high clinical stage T nodal...
Backgrounds/Aims The aim of this retrospective study is to compare stomach cancer incidence, characteristics between gallstones, cholecystectomy and control groups. It also aims investigate key variables' potential effects on overall survival. Methods A total 99 patients, diagnosed with cancers April 1994 December 2015, were identified. We excluded accrued during the first year follow-up in both gallstones groups, assuming that they missed cancers. main analyses addressing objective a...
Background: Increasing clarithromycin resistance has led to changes in several guidelines for treatment of Helicobacter pylori infections. We compared the H. eradication rates empirical concomitant therapy (CoT) and a tailored (TaT) using dual-priming oligonucleotide-based polymerase chain reaction detect mutations 23S rRNA gene that are related resistance. Methods: Between June 2020 May 2021, 290 patients were enrolled randomly assigned 2 groups. In CoT group, received rabeprazole 20 mg,...
See editorial "Is serum pepsinogen testing necessary in populationbased screening for gastric cancer?" on page 544.
Background: To determine the activity and toxicities of a low-dose leucovorin plus 5-fluorouracil (5-FU) regimen, combined with irinotecan administered every 2 weeks (modified FOLFIRI), as first-line therapy for patients advanced gastric cancer. Method: Patients were treated cycles 150 mg/m2 on day 1 50 mg LV, followed by 400 5-FU bolus 22-hour continuous infusion 600 days 2. Results: The median patient age was 55 years (range, 29–75 years), 77% (34/44) had performance status (Eastern...
Background/Aims The aim of the study was to evaluate efficacy i-scans for diagnosis gastroesophageal reflux disease, especially where only minimal change is involved. Methods esophageal mucosa inspected using an i-scan following conventional white light endoscopy. examination with iscan performed under tone enhancement (TE) esophagus (e) mode. Patients subtle distal mucosal changes without definite breaks, such as blurring Z-line (B), coarseness (C), hyperemic or purplish discoloration (D),...
Objective. Although there have been many reports regarding clinical outcomes of endoscopic treatment for early gastric cancer (EGC), little is known about detection recurrence after submucosal dissection (ESD). This study aims to clarify the value serological marker or imaging tools, including conventional CT and PET-CT scans, in detecting recurrent ESD Korea. Material methods. From July 2004 March 2008, 212 patients who had received EGC were enrolled study. For preoperative staging, scans...
Patients with diabetes mellitus (DM) are more likely to have a pyogenic liver abscess gas formation, which is associated higher morbidity and mortality. The mortality in also DM patients than non-DM patients. This study evaluated the morbidity, mortality, clinical features gas-forming abscesses DM.Among 379 cases of excluding malignancy from January 2001 through December 2009, 25 treated for pyogenic-gas-forming were reviewed retrospectively. We compared findings between patients.Gas...
This study compared the efficacy of DA-9601 (Dong-A ST Co. , Seoul, Korea) and its new formulation, DA-5204 Co.), for treating erosive gastritis.This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: 3 times daily or DA-5,204 twice 2 weeks.The final analysis included 421 209; 212).The primary endpoint (rate effective erosion healing) secondary endpoints (cure rate...
Hyuk Yoon, Dong Ho Lee, Yong-Hyun Ju-Cheol Jeong, Soo Teik Myung-Gyu Choi, Seong Woo Jeon, Ki-Nam Shim, Gwang Baik, Jae Gyu Kim, Jeong Seop Moon, In-Kyung Sung, Sang Kil Poong-Lyul Rhee, Hwoon-Yong Jung, Bong Eun Hyun Gyun Kee Myung Kyu Seong, Jin Seok Jang, and Jong-Jae Park. Gut Liver 2018;12:516-22. https://doi.org/10.5009/gnl17416