A5032688509- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- COVID-19 diagnosis using AI
- Viral Infections and Outbreaks Research
- CAR-T cell therapy research
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Lymphoma Diagnosis and Treatment
- Lower Extremity Biomechanics and Pathologies
- Viral Infectious Diseases and Gene Expression in Insects
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- MRI in cancer diagnosis
- Viral gastroenteritis research and epidemiology
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Veterinary Orthopedics and Neurology
- Machine Learning and Data Classification
- Supercapacitor Materials and Fabrication
Dong-A University
2023-2025
National Institute of Allergy and Infectious Diseases
2019-2024
National Institutes of Health
2019-2024
Korea Institute of Industrial Technology
2024
Anyang University
2024
Hanyang University
2024
Dong-A University Hospital
2023
National Institutes of Health Clinical Center
2022-2023
Oakland University
2011-2021
University of Rochester
2011-2015
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an exponentially increasing number of disease 19 (COVID-19) cases globally. Prioritization medical countermeasures for evaluation in randomized clinical trials critically hindered by the lack COVID-19 animal models that enable accurate, quantifiable, and reproducible measurement pulmonary free from observer bias. We first used serial computed tomography (CT) to demonstrate bilateral intrabronchial instillation SARS-CoV-2...
Abstract Background Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma (NHL); however, most patients ultimately relapse. Several mechanisms contribute to this failure, including CD19-negative escape and CAR T dysfunction. All four commercial CART19 products utilize the FMC63 single-chain variable fragment (scFv) specific a CD19 membrane-distal epitope characterized by slow association (on) dissociation (off)...
Cell therapy promotes brain remodeling and improves functional recovery after various central nervous system disorders, including traumatic injury (TBI). We tested the hypothesis that treatment of TBI with intravenous administration human marrow stromal cells (hMSCs) provides therapeutic benefit in modifying hemodynamic structural abnormalities, which are detectable by vivo MRI. hMSCs were labeled superparamagnetic iron oxide (SPIO) nanoparticles. Male Wistar rats (300-350 g, n=18) subjected...
Significance Ebola virus (EBOV) infection is a severe, often fatal disease with poorly understood pathophysiology. Here, we performed [ 18 F]-DPA-714 Positron Emission Tomography (PET) in macaque model of EBOV to longitudinally track and quantify the translocator protein (TSPO), an immune cell marker. The imaging findings, along immunohistology other markers, showed increasing stem proliferation bone marrow, progressive monocytic lymphocytic loss spleen lungs. This study provides real-time...
Carbonaceous materials are attractive active for the manufacture of flexible electrochemical double-layer capacitors (EDLCs) because their high electrical conductivity, large surface area, and inherent resilience against deformation.
Abstract To investigate the dependency of T 1 relaxation on mechanical strain in articular cartilage, quantitative magnetic resonance imaging experiments were carried out cartilage before/after tissue was immersed gadolinium contrast agent and when being compressed (up to ∼48% strains). The spatial resolution across depth 17.6 μm. profile native (without presence ions) strongly strain‐dependent, which is also depth‐dependent. At modest strains (e.g., 14% strain), reduced by up 68% most...
Abstract Despite increasing evidence that uveitis is common and consequential in survivors of Ebola virus disease (EVD), the host-pathogen determinants clinical phenotype are undefined, including pathogenetic role persistent viral antigen, ocular tissue-specific immune responses, histopathologic characterization. Absent sampling human intraocular fluids tissues, these questions might be investigated animal models disease; however, challenges intrinsic to nonhuman primate model biosafety...
Abstract To investigate the structural anisotropy in bovine septal cartilage, quantitative procedures microscopic magnetic resonance imaging (μMRI), polarized light microscopy (PLM), and mechanical indentation were used to measure tissue three orthogonal planes: vertical, medial, caudocephalic. The T2 experiments μMRI found strong images of both vertical caudocephalic planes but little from medial plane. PLM birefringent that retardation values section only about 10% these sections angle all...
The topographical variations of the zonal properties canine articular cartilage over medial tibia were evaluated as function external loading by microscopic magnetic resonance imaging (µMRI). T2 and T1 relaxation maps GAG (glycosaminoglycan) images from a total 70 specimens obtained with without mechanical at 17.6 µm depth resolution. In addition, modulus water content measured tissue. For bulk loading, means magic angle (43.6 ± 8.1 ms), absolute thickness (907.6 187.9 µm) (63.3 9.3%) on...
In this paper, we propose a tone mapping (TM) method using color correction function (CCF) and image decomposition in high dynamic range (HDR) imaging. The CCF the proposed TM is derived from luminance compression with constraint under which ratios, between three channels of radiance map term, are preserved saturation controlled. developed to locally perform control local TM. For decomposition, use bilateral filter apply adaptive weight base layer luminance. Computer simulations various sets...
Abstract Nipah virus (NiV) is an emerging associated with outbreaks of acute respiratory disease and encephalitis. To develop a neurological model for NiV infection, we exposed 6 adult African green monkeys to large-particle (approximately 12 μm) aerosol containing (Malaysian isolate). Brain magnetic resonance images were obtained at baseline, every 3 days after exposure 2 weeks, then weekly until week 8 exposure. Four six animals showed abnormalities reminiscent human in brain images....
Abstract Ebola virus (EBOV) causes neurological symptoms yet its effects on the central nervous system (CNS) are not well-described. Here, we longitudinally assess acute of EBOV brain, using quantitative MR-relaxometry, 18F-Fluorodeoxyglucose PET and immunohistochemistry in a monkey model. We report blood–brain barrier disruption, likely related to high cytokine levels endothelial viral infection, with extravasation fluid, Gadolinium-based contrast material albumin into extracellular space....
The predictable outcome of the anterior cruciate ligament transection (ACLT) canine model, and similarity to naturally occurring osteoarthritis (OA) in humans, provide a translatable method for studying OA. Still, evidence direct meniscus-induced cartilaginous damage has not been identified, gross-anatomical blinded scoring early-stage OA performed.A gross anatomical observation statistical analysis progression determine meniscus induced damage, measure macroscopic OA, address matters...
Staphylococcus pseudintermedius is a frequent cause of infections in dogs. Infectious isolates this coagulase-positive staphylococcal species are often methicillin- and multidrug-resistant, which complicates therapy. In staphylococci, methicillin resistance encoded by determinants found on mobile genetic elements called Staphylococcal Chromosome Cassette mec (SCCmec), which, addition to factors, sometimes encode additional genes, such as further factors and, rarely, virulence determinants....
ABSTRACT Microscopic magnetic resonance imaging (µMRI) T2 data from canine cartilage at different tibial locations were analyzed to investigate the influences of spatial resolution and pixel position on sensitivity osteoarthritis (OA). Five experimental factors investigated: inaccurate position, resolutions, specimen orientations in field, topographical variations over surface, OA stages. A number significant trends identified this analysis, which shows subtle but substantial our abilities...
Severe liver impairment is a well-known hallmark of Ebola virus disease (EVD), but the contribution hepatic pathophysiology to EVD progression not fully understood. Noninvasive medical imaging structure and function in well-established animal models may shed light on this important aspect EVD.
Bone marrow (BM) involvement is an indicator of a poor prognosis in diffuse large B-cell lymphoma (DLBCL); however, few studies have evaluated the role immunoglobulin gene rearrangement (IgR) detecting BM involvement.