A5102778771- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Epigenetics and DNA Methylation
- Healthcare and Venom Research
- Corporate Taxation and Avoidance
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Liver Disease Diagnosis and Treatment
- Hematological disorders and diagnostics
- Palliative Care and End-of-Life Issues
- Cancer therapeutics and mechanisms
- Cancer survivorship and care
- Adenosine and Purinergic Signaling
- Advanced Breast Cancer Therapies
- Blood groups and transfusion
Seoul National University Hospital
2009-2025
Seoul National University
2007-2025
Sungkyunkwan University
2001-2024
CHA University
2022-2023
Kyung Hee University Hospital at Gangdong
2017-2020
New Generation University College
2010
Yeungnam University
2007
Zero to Three
2006
Samsung Medical Center
2002
University of Newcastle Australia
2002
The incidence of multiple myeloma (MM) is known to be variable according ethnicity. However, the differences in clinical characteristics between ethnic groups are not well‐defined. In Asian countries, although MM has been lower than that Western there growing evidence increasing rapidly. Myeloma Network decided initiate first multinational project describe and practices Asia. Data were retrospectively collected from 23 centers 7 countries regions. at diagnosis, survival rates initial...
To gain insight into people's thoughts on stroke and to inform the development of educational strategies in community.Focus group discussions: two groups people who had a their carers, members general public.New South Wales, Australia.35 participated: 11 from public, 14 stroke, 10 carers or partners.Views risk factors, symptoms, treatment, information resources, prevention.All reported similar knowledge factors. People generally mentioned stress, diet, high blood pressure, age, smoking as...
Upfront high-dose myeloablative chemotherapy followed by a single autologous stem cell transplantation (ASCT) is the standard therapy for patients under age of 65 years with newly diagnosed multiple myeloma (MM). Because disease status after induction variable, we evaluated prognostic effect before ASCT, especially in who were initially chemosensitive. We retrospectively analyzed chemosensitive MM (> or = partial remission [PR]) enrolled Korean Multiple Myeloma Working Party Web-based...
Abstract Background Atypical hemolytic uremic syndrome (aHUS) triggered by pregnancy is a rare disease caused dysregulation of the alternative complement pathway that occurs in approximately 1 25,000 pregnancies. The 311 phase 3 trial (NCT02949128) showed ravulizumab, long-acting C5 inhibitor obtained through selective modifications to eculizumab, efficacious inhibiting complement-mediated thrombotic microangiopathy (TMA) patients with aHUS. In this analysis, we report outcomes subgroup from...
High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in various peripheral subtypes, optimal transplant timing, and prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated clinical outcomes 64 Korean lymphoma, unspecified (PTCL-U) between March 1995 February 2007. The median age at was 44 years (range:...
Abstract Hodgkin lymphoma exhibits high PD-L1 expression and responds well to PD-1 blocking antibodies. In contrast, most non-Hodgkin lymphomas express multiple checkpoints, reducing their sensitivity PD-1/PD-L1 blockade. These findings highlight the complexity of immune evasion mechanisms potential combinatorial therapeutic approaches in lymphoma. We established cell lines overexpressing murine CD155 luciferase using lentivirus measure tumor growth mouse models B All experimental procedures...
Abstract Background: Multiple myeloma (MM) is characterized by the neoplastic proliferation of a single clone plasma cells that produce monoclonal immunoglobulins. Among its subtypes, immunoglobulin D multiple (IgD MM) rare, accounting for less than 2% all MM cases. IgD often associated with rapid disease progression at diagnosis, an aggressive clinical course, and poor prognosis compared other subtypes. Methods: Samples were collected from patients diagnosed through bone marrow examination,...
We previously analyzed serial bone marrow (BM) aspirates from a patient with high-risk myelodysplastic syndrome (HR-MDS) who responded to hypomethylating agent (HMA), azacitidine using single-cell RNA sequencing. Our finding showed an increased proportion of NK cells in the BM, elevated CXCR4 expression following treatment (Hong J, et al. AACR 2023). Building on these observations, we tested our hypothesis that HMA can potentiate BM homing and cytotoxic effect myeloid leukemia. To test...
Abstract Invasive pulmonary aspergillosis is a serious infectious complication in immunocompromised patients. Recent reports indicate its favorable clinical outcomes by early diagnosis with chest computed tomography scan. We retrospectively analyzed our experiences histopathological evaluation open lung biopsy 31 patients (32 cases) hematologic malignancies, suspected of having invasive clinically and radiologically. Although the initial findings all cases were highly indicative...
To investigate the correlation of trough imatinib mesylate (IM) levels with cytogenetic or molecular responses, we measured IM in patients chronic myeloid leukemia, phase (CML-CP), at 6 months treatment a standard dose IM. Eighty-seven newly diagnosed CML-CP were prospectively enrolled. Seventy-eight (89.7%) showed an optimal response (complete partial response) months. Trough 1378 ± 725 ng/mL. When categorized into two groups, there was statistically significant difference numbers and...
Background: Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim this study was to investigate efficacy safety traditional herbal medicine Gamiguibi-tang (GGBT) cancer-related sleep disturbance. Methods: We conducted a prospective, randomized, wait-list-controlled, open-label pilot clinical trial on Patients cancer experiencing poor Pittsburgh Quality Index at least 6 were randomly assigned GGBT...
Abstract Fluorescence in situ hybridization for the BCR / ABL rearrangement 138 bone marrow specimens from 59 Philadelphia + (Ph ) chronic myelogenous leukemia (CML) patients, 35 Ph acute lymphoblastic (ALL) and 57 − ALL patients was used. Sixteen (27.1%) of CML had deletions residual gene on derivative chromosome 9. During study period, 32 progressed to blast crisis or accelerated phase. Of these, nine chromosomes 9 23 no deletions. The mean duration first diagnosis phase with 32.8 months,...
Gene Expression Profile during Chondrogenesis in Human Bone Marrow derived Mesenchymal Stem Cells using a cDNA MicroarrayMesenchymal stem cells (MSCs) have the capacity to proliferate and differentiate into multiple connective tissue lineages, which include cartilage, bone, fat.Cartilage differentiation chondrocyte maturation are required for normal skeletal development, but intracellular pathways regulating this process remain largely unclear.This study was designed identify novel genes...
Due to the high risk of thrombocytopenia and haemorrhage, thrombotic complications have received little attention in patients with acute myeloid leukemia (AML). Furthermore, predictive role cytogenetics on venous thromboembolism (VTE) has largely been ignored. This study aimed evaluate incidence, factors, prognostic aspects VTE AML. A total 811 consecutive AML were enrolled analysed retrospectively. Cox time-dependent covariate regression analysis was used identify significant predictors...
L-ascorbic acid (LAA) modifies the in vitro growth of leukemic cells from approximately 50% patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). To test hypothesis that depletion LAA, alternating supplementation to prevent scurvy, would provide therapeutic benefit, a single-arm pilot trial was conducted (ClinicalTrials.gov identifier: NCT00329498). Experimental results: During phase, refractory AML MDS were placed on diet deficient LAA; during received daily...
Obesity is a risk factor for COVID-19. However, it unknown whether weight changes can alter this risk. We investigated the association of with SARS-CoV-2 infection and acute severe COVID-19 outcomes occurring within two months infection.We used 6.3 million nationwide cohort. The body was classified as follows: (1) underweight, mass index (BMI) < 18.5 kg/m2; (2) normal, BMI 18.5-22.9 (3) overweight, 23-24.9 (4) obese, BMI≥ 25 kg/m2. Weight were defined by comparing classification during...