A5065816117- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Parkinson's Disease Mechanisms and Treatments
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Medical Imaging Techniques and Applications
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Pain Management and Treatment
- Vestibular and auditory disorders
- Medical Imaging and Analysis
- Restless Legs Syndrome Research
- Complex Network Analysis Techniques
- Cervical and Thoracic Myelopathy
- Hemispheric Asymmetry in Neuroscience
- Health, Environment, Cognitive Aging
- Psychosomatic Disorders and Their Treatments
Icahn School of Medicine at Mount Sinai
2018-2025
Circuit Therapeutics (United States)
2018-2025
Emory University
2013-2024
New York Proton Center
2024
Imaging Center
2024
Dartmouth Hospital
2023
The University of Texas Southwestern Medical Center
2022
Mount Sinai Hospital
2021
Mount Sinai Health System
2021
University of Miami
2017
Objective: The purpose of this article was to inform the first-line treatment choice between cognitive-behavioral therapy (CBT) or an antidepressant medication for treatment-naive adults with major depressive disorder by defining a neuroimaging biomarker that differentially identifies outcomes remission and failure these interventions. Method: Functional MRI resting-state functional connectivity analyses using bilateral subcallosal cingulate cortex (SCC) seed applied 122 patients from...
Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error adjustments due to individual trajectories and subjective reporting 3 We currently lack objective brain-based biomarkers guide clinical decisions by distinguishing natural transient mood fluctuations from situations intervention. To address this...
The clinical utility of monitoring behavioral changes during intraoperative testing subcallosal cingulate deep brain stimulation is unknown.
Abstract Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action not fully understood and therapeutic benefit varies among individuals. We used a targeted metabolomics approach utilizing panel 180 metabolites to gain insights into response citalopram/escitalopram. Plasma samples from 136 participants with MDD enrolled Mayo Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study...
Abstract It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, associated with symptoms depression and anxiety. Serum samples (baseline, 12 weeks) were drawn participants (n = 196) randomized to treatment cognitive behavioral therapy (CBT), escitalopram, or duloxetine for major depressive disorder. Baseline indoxyl sulfate abundance was positively correlated severity psychic anxiety total resting state functional connectivity...
Objective: The authors sought to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission cognitive-behavioral therapy (CBT) or antidepressant medication. Methods: Predictors of Remission Depression Individual Combined Treatments (PReDICT) trial randomized adults treatment-naive 12 weeks treatment CBT (16 1-hour sessions) medication (duloxetine 30–60 mg/day escitalopram 10–20 mg/day)....
Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the dimensions that characterize MDD and predict treatment response selective serotonin reuptake inhibitor (SSRI) antidepressants or placebo. In COORDINATE-MDD consortium, raw MRI data were shared from international samples (
Subcallosal cingulate cortex deep brain stimulation (SCC-DBS) is an experimental therapy for treatment-resistant depression (TRD). Refinement and optimization of SCC-DBS will benefit from increased study SCC electrophysiology in context ongoing high-frequency therapy. The objective was a 7-mo observation frequency-domain 1/f slope off-stimulation local field potentials (SCC-LFPs) alongside standardized measurements severity 4 patients undergoing SCC-DBS. implanted bilaterally with combined...
Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is a promising intervention for treatment-resistant depression (TRD). Despite failure clinical trial, multiple case series have described encouraging results, especially with introduction improved surgical protocols. Recent evidence further suggests that tractography targeting and intraoperative exposure to enhances early antidepressant effects evolve ongoing chronic DBS. Accelerating treatment gains critical care this...
Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment‐resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways that estimated from patient‐specific computational models. This connectomic‐based biophysical modeling strategy has proven successful improving clinical response to therapy, but models used date have been relatively simplistic, limiting precision...
Awake neurosurgery requires patients to converse and respond visual or verbal prompts identify protect brain tissue supporting essential functions such as language, primary sensory modalities, motor function. These procedures can be poorly tolerated because of patient anxiety, yet acute anxiolytic medications typically cause sedation impair cortical function.In this study, direct electrical stimulation the left dorsal anterior cingulum bundle was discovered reliably evoke positive affect...
Efforts to develop neuroimaging-based biomarkers in major depressive disorder (MDD), at the individual level, have been limited date. As diagnostic criteria are currently symptom-based, MDD is conceptualized as a rather than disease with known etiology; further, neural measures often confounded by medication status and heterogeneous symptom states.
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily the novel uses of existing technology as well next-generation technology. Our keynote speaker shared vision using neuro artificial intelligence predict depression brain electrophysiology. Innovative applications are currently being explored stroke, disorders consciousness, and sleep, while established treatments...