A5058415831- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Mechanical Circulatory Support Devices
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- EEG and Brain-Computer Interfaces
- Anatomy and Medical Technology
- Vestibular and auditory disorders
- Obsessive-Compulsive Spectrum Disorders
- Pelvic and Acetabular Injuries
- Digital Image Processing Techniques
- Cardiac and Coronary Surgery Techniques
- Colorectal Cancer Surgical Treatments
- Surgical Simulation and Training
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Trauma Management and Diagnosis
- Cardiac pacing and defibrillation studies
Duke University
2022-2024
Pratt Institute
2023-2024
Case Western Reserve University
2014-2023
Cleveland Clinic
2005-2012
Cleveland Clinic Lerner College of Medicine
2005-2007
Hershey (United States)
2007
Cleveland Foundation
2005
The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application several other disorders, including treatment-resistant depression. Results with DBS depression have been heterogeneous, inconsistencies largely driven by incomplete understanding the networks regulating mood, especially on an individual basis. We report results from first subject treated using approach that incorporates intracranial recordings personalize network behavior and response...
Deep brain stimulation in the subthalamic nucleus is an effective and safe surgical procedure that has been shown to reduce motor dysfunction of patients with advanced Parkinson's disease. Bilateral deep stimulation, however, associated declines cognitive cognitive–motor functioning. It hypothesized spread current nonmotor areas may be responsible for The aim this study was assess performance disease parameters determined clinically (Clinical) settings derived from a patient-specific...
The availability of algorithms to create three-dimensional (3D) models from medical images has made it possible render and build patient-specific reconstructions individual body parts. In the present study, this technology was used 3D pediatric hearts for use in device development. Digital were created using CT datasets commercially available image processing software. Using software, stacked data viewed, pixels representing heart rib cage selected rendered as models. Stereolithography...
To create a data-driven computational model that identifies brain regions most frequently influenced by successful deep stimulation (DBS) of the globus pallidus (GP) for advanced, medication-resistant, generalized dystonia.We studied retrospective cohort 21 DYT1 primary dystonia patients treated at least 1 year with bilateral pallidal DBS. We first created individual volume tissue activation (VTA) models utilizing neuroimaging and postoperative clinical data. These were then combined into...
BackgroundThe efficacy of psychiatric DBS is thought to be driven by the connectivity stimulation targets with mood-relevant fronto-temporal networks, which typically evaluated using diffusion-weighted tractography.ObjectiveLeverage intracranial electrophysiology recordings better predict circuit-wide effects neuromodulation white matter targets. We hypothesize strong convergence between tractography-predicted structural and stimulation-induced electrophysiological responses.MethodsEvoked...
Deep brain stimulation (DBS) is an established clinical therapy for the treatment of Parkinson's disease. However, selecting parameters maximal benefit can be a difficult and time consuming process that typically requires highly trained experienced individual to achieve acceptable results. To address this limitation we developed Windows-based software package (StimExplorer) intended aid implementation DBS technology. StimExplorer uses detailed computer models provide quantitative description...
<i>Objective:</i> Deep brain stimulation (DBS) surgeries commonly rely on atlases and microelectrode recordings (MER) to help identify the target location for electrode implantation. We present an automated method optimally fitting a 3-dimensional atlas intraoperative MER predicting DBS in stereotactic coordinates patient. <i>Methods:</i> retrospectively fit points from 10 targeting subthalamic nucleus (STN). used constrained optimization algorithm maximize correctly...
The subthalamic nucleus (STN) is a common anatomical target for deep brain stimulation (DBS) the treatment of Parkinson's disease. However, effects may spread beyond STN. Ongoing research aims to identify nearby structures where DBS-induced could be associated with therapeutic improvement or side effects. We previously found that DBS lead location determines rate – abrupt vs. gradual which effect washes out after stopped. Those results suggested electrical current spreads from electrodes two...
Bilateral subthalamic (STN) deep brain stimulation (DBS) is effective in improving the cardinal motor signs of advanced Parkinson's disease (PD); however declines cognitive function have been associated with this procedure. The aim study was to assess cognitive-motor performance 10 PD patients implanted STN DBS systems during either clinically determined settings or derived from a computational model. Cicerone software used define model parameters such that current spread non-motor areas...
Abstract Background Efficacy of deep brain stimulation (DBS) relies on accurate lead placement as well optimization the parameters. Although clinical software tools are now available, programming still largely a monopolar review, tedious process for both patients and programmers. Objective This study investigates safety feasibility prospective automated connectomic DBS (automated [ACP]), focusing recruitment specific white matter pathways. Methods After implantation, detailed model in...
The PediPump is a new ventricular assist device with hydraulic output range designed for children from newborn infants to adolescents. design based on mixed-flow rotary pump; the rotating assembly consists of front impeller, and rear radial magnetic bearings, central motor magnet. Two different implantable pumps were initially: an intravascular pump measuring 7 x 75 mm extravascular 14 85 mm. Current prototypes are substantially smaller: current version measures 4.5 55 mm, whereas 11 70 Both...
Bilateral subthalamic (STN) deep brain stimulation (DBS) is generally effective in improving the cardinal motor signs of advanced Parkinson's disease (PD). However, many cases postural instability refractory to STN DBS. The goal this project was determine if could be improved with DBS by avoiding current spread non-motor territories STN. Stimulation parameters that maximized activation a theoretically defined target region were determined via patient-specific computer models created...
Accurate and precise delineation of the globus pallidus pars interna (GPi) subthalamic nucleus (STN) is critical for clinical treatment research Parkinson's disease (PD). Automated segmentation a developing technology which addresses limitations visualizing deep nuclei on MR imaging standardizing their definition in applications. We sought to compare manual with three workflows template-to-patient nonlinear registration providing atlas-based automatic nuclei.Bilateral GPi, STN, red (RN) were...