A5078304731- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Multisensory perception and integration
- Neuroscience and Music Perception
- Neuroscience and Neural Engineering
- Face Recognition and Perception
- Mental Health Research Topics
- Visual Attention and Saliency Detection
- Advanced Computing and Algorithms
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Neuroscience and Neuropharmacology Research
- Conducting polymers and applications
- Treatment of Major Depression
- Brain Tumor Detection and Classification
- Spatial Neglect and Hemispheric Dysfunction
- Advanced Optical Sensing Technologies
- Image Enhancement Techniques
- Noise Effects and Management
- Obsessive-Compulsive Spectrum Disorders
- Sensor Technology and Measurement Systems
Baylor College of Medicine
2019-2025
Swarthmore College
2023-2024
University of Illinois Urbana-Champaign
2014-2019
University of Nevada, Las Vegas
2013
North Carolina State University
2010
Harbor Branch Oceanographic Institute
2010
The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application several other disorders, including treatment-resistant depression. Results with DBS depression have been heterogeneous, inconsistencies largely driven by incomplete understanding the networks regulating mood, especially on an individual basis. We report results from first subject treated using approach that incorporates intracranial recordings personalize network behavior and response...
Disorders of mood and cognition are prevalent, disabling, notoriously difficult to treat. Fueling this challenge in treatment is a significant gap our understanding their neurophysiological basis. We recorded high-density neural activity from intracranial electrodes implanted depression-relevant prefrontal cortical regions 3 human subjects with severe depression. Neural recordings were labeled depression severity scores across wide dynamic range using an adaptive assessment that allowed...
The insula plays a fundamental role in wide range of adaptive human behaviors, but its electrophysiological dynamics are poorly understood. Here, we used intracranial electroencephalographic recordings to investigate the properties and hierarchical organization spontaneous neuronal oscillations within insula. We analyzed directly found that rhythms theta beta frequency widespread spontaneously present. These largely organized along anterior-posterior (AP) axis Both left right showed...
Abstract Depression is associated with a cognitive bias towards negative information and away from positive information. This biased emotion processing may underlie core depression symptoms, including persistent feelings of sadness reduced capacity to experience pleasure. The neural mechanisms responsible for this remain unknown. Here we had unique opportunity record stereotactic electroencephalography signals in the amygdala prefrontal cortex (PFC) 5 patients treatment-resistant (TRD) 12...
Visual information about speech content from the talker's mouth is often available before auditory voice. Here we examined perceptual and neural responses to words with without this visual head start. For both types of words, perception was enhanced by viewing face, but enhancement significantly greater for a Neural were measured electrodes implanted over association cortex in posterior superior temporal gyrus (pSTG) epileptic patients. The presence suppressed speech, more so We suggest that...
BackgroundThe efficacy of psychiatric DBS is thought to be driven by the connectivity stimulation targets with mood-relevant fronto-temporal networks, which typically evaluated using diffusion-weighted tractography.ObjectiveLeverage intracranial electrophysiology recordings better predict circuit-wide effects neuromodulation white matter targets. We hypothesize strong convergence between tractography-predicted structural and stimulation-induced electrophysiological responses.MethodsEvoked...
Introduction Deep brain stimulation (DBS) is a promising treatment for refractory depression, utilizing surgically implanted electrodes to stimulate specific anatomical targets within the brain. However, limitations of patient-reported and clinician-administered mood assessments pose obstacles in evaluating DBS efficacy. In this study, we investigated whether an affective bias task, which leverages inherent negative interpretation seen individuals with could serve as reliable measure changes...
Abstract Emotion is represented in limbic and prefrontal brain areas, herein termed the affective salience network (ASN). Within ASN, there are substantial unknowns about how valence emotional intensity processed—specifically, which nodes associated with bias (a phenomenon participants interpret emotions a manner consistent their own mood). A recently developed feature detection approach (‘specparam’) was used to select dominant spectral features from human intracranial electrophysiological...
Experimentalists studying multisensory integration compare neural responses to stimuli with the component modalities presented in isolation. This procedure is problematic for speech perception since audiovisual and auditory-only are easily intelligible but visual-only not. To overcome this confound, we developed intracranial encephalography (iEEG) deconvolution. Individual always contained both auditory visual speech, jittering onset asynchrony between allowed time course of unisensory...
A reliable physiological biomarker for Major Depressive Disorder (MDD) is necessary to improve treatment success rates by shoring up variability in outcome measures. In this study, we establish a passive that tracks with changes mood on the order of minutes hours. We record from intracranial electrodes implanted deep brain - surgical setting providing exquisite temporal and spatial sensitivity detect relationship difficult-to-measure area, ventromedial prefrontal cortex (VMPFC). The...
The mechanisms of visuospatial attention are mediated by two distinct fronto-parietal networks: a bilateral dorsal network (DAN), involved in the voluntary orientation attention, and ventral (VAN), lateralized to right hemisphere, reorienting unexpected, but relevant, stimuli. present study consisted aims: 1) characterize spatio-temporal dynamics 2) examine predictive interactions between within systems along with visual areas, using fast optical imaging combined Granger causality. Data were...
A reliable physiological biomarker for Major Depressive Disorder is essential developing and optimizing neuromodulatory treatment paradigms. This study investigates a passive electrophysiologic that tracks changes in depressive symptom severity on the order of minutes to hours. We analyze brief recordings from intracranial electrodes implanted deep brain during clinical trial stimulation treatment-resistant depression 5 human subjects (nfemale= 3, nmale = 2). surgical setting allows precise...
This study determined whether facilitation of auditory stream segregation could occur when facilitating context tones are accompanied by other sounds. Facilitation was measured as the likelihood a repeated tone that match low (A) or high (B) frequency repeating ABA test to increase hearing segregated. We observed this type matching were alone, with simultaneous bandpass noises continuous speech, neither which masked tones. However, participants showed no streaming harmonic complex Mistuning...
Over the last several decades developments in Underwater Laser Line Scan (LLS) systems have resulted significant improvements turbid water imaging performance. In addition to allowing for high quality image acquisition through tens of attenuation lengths, recently renewed interest multiple platform distributed LLS configurations also has potential synoptic coverage much larger regions seabed. A related issue worth investigation is how utilize these capabilities improve rendering underwater...
Research on the neural correlates of consciousness (NCC) has implicated an assortment brain regions, ERP components, and network properties associated with visual awareness. Recently, P3b component emerged as a leading NCC candidate. However, typical paradigms depend detection some stimulus change, making it difficult to separate processes elicited by itself from those updates or changes in Here we used binocular rivalry ask whether is awareness even absence object We recorded ERPs during...
Abstract Depression is associated with a cognitive bias towards negative information and away from positive information. This biased emotion processing may underlie core depression symptoms, including persistent feelings of sadness or low mood reduced capacity to experience pleasure. The neural mechanisms responsible for this remain unknown. Here, we had unique opportunity record stereotactic electroencephalography (sEEG) signals in the amygdala prefrontal cortex (PFC) 5 treatment-resistant...
Abstract Experimentalists studying multisensory integration compare neural responses to stimuli with the component modalities presented in isolation. This procedure is problematic for speech perception since audiovisual and auditory-only are easily intelligible but visual-only not. To overcome this confound, we developed intracranial encephalography (iEEG) deconvolution. Individual always contained both auditory visual jittering onset asynchrony between allowed time course of unisensory...
<title>Abstract</title> Disrupted cortical and peripheral neural responses to salient stimuli occur in disease states, which may be rooted pathophysiological neuromodulatory system dynamics. Although low-frequency oscillatory activity is the canonical measure of state, aperiodic 1/f slope encapsulates balance between high-frequency could thus provide a more sensitive electrophysiological measure. Here, we simultaneously record pupil diameter as noninvasive brain intracranial local field...
Alteration of responses to salient stimuli occurs in a wide range brain disorders and may be rooted pathophysiological state dynamics. Specifically, tonic phasic modes activity the reticular activating system (RAS) influence, are influenced by, stimuli, respectively. The RAS influences spectral characteristics neocortex, shifting balance between low- high-frequency fluctuations. Aperiodic '1/f slope' has emerged as promising composite measure these However, relationship 1/f slope...
Abstract Background: Deep brain stimulation for TRD faces critical unknowns, including defining the modulated network, and characterizing response patterns to optimize parameter selection. In a novel experimental setting – patients undergoing DBS with temporary stereotactic EEG (sEEG) electrodes across frontotemporal networks we study network structure using single-pulse evoked potential paradigm, then undertake new approach selection guided by electrophysiology. Methods: We applied our...