A5100752550- Plasma Applications and Diagnostics
- Advanced MRI Techniques and Applications
- Microbial Inactivation Methods
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Electrohydrodynamics and Fluid Dynamics
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Pluripotent Stem Cells Research
- Mycotoxins in Agriculture and Food
- Laser Applications in Dentistry and Medicine
- Advanced biosensing and bioanalysis techniques
- Plasma Diagnostics and Applications
- Surface Modification and Superhydrophobicity
- Olfactory and Sensory Function Studies
- Advanced Neuroimaging Techniques and Applications
- Biosensors and Analytical Detection
- Dental materials and restorations
- Intraperitoneal and Appendiceal Malignancies
- Membrane Separation Technologies
Peking University
2016-2025
Morgridge Institute for Research
2013-2025
Foshan Hospital of TCM
2022-2025
Guangzhou University of Chinese Medicine
2025
Inner Mongolia Normal University
2024-2025
Versiti Blood Center of Wisconsin
2022-2024
Jiangsu Provincial Academy of Forestry Science and Management
2010-2024
Wannan Medical College
2022-2024
Nanjing General Hospital of Nanjing Military Command
2019-2024
China Power Engineering Consulting Group (China)
2024
The protein α-synuclein has a central role in Parkinson disease, but the mechanism by which it contributes to neural degeneration remains unknown. We now show that expression of mammalian cells, including neurons vitro and vivo, causes fragmentation mitochondria. effect is specific for synuclein, with more α- than β- or γ-isoforms, not accompanied changes morphology other organelles mitochondrial membrane potential. However, eventually followed decline respiration neuronal death. does...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of molecular weight distributions fulvic and humic acids using flow field-flow fractionationRonald. Beckett, Zhang. Jue, J. Calvin. GiddingsCite this: Environ. Sci. Technol. 1987, 21, 3, 289–295Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/es00157a010https://doi.org/10.1021/es00157a010research-articleACS PublicationsRequest reuse...
Abstract Water activated by non-thermal plasma creates an acidified solution containing reactive oxygen and nitrogen species, known as plasma-activated water (PAW). The objective of this study was to investigate the effects different storage temperatures (25 °C, 4 −20 −80 °C) on bactericidal activities against S. aureus physicochemical properties PAW up 30 days. Interestingly, stored at °C yielded best antibacterial activity Staphylococcus , 3~4 log reduction over a 30-day period after...
Electrical models for biological cells predict that reducing the duration of applied electrical pulses to values below charging time outer cell membrane (which is on order 100 ns mammalian cells) causes a strong increase in probability electric field interactions with intracellular structures due displacement currents. For amplitudes exceeding MV/m, such are also expected allow access interior through conduction currents flowing permeabilized plasma membrane. In both cases, limiting...
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce number of drug failures clinical trials and offer a cost-effective approach for assessing chemical safety. Here, embryonic (ES) cell-derived neural progenitor cells, endothelial mesenchymal microglia/macrophage precursors were combined on chemically defined polyethylene glycol hydrogels cultured serum-free medium model cellular interactions within developing brain. The self-assembled...
A direct current atmospheric pressure cold plasma microjet (PMJ) was used to produce activated water (PAW) in two generation modes above (PAW‐A) and beneath (PAW‐B) the surface. The physicochemical characteristics biological effects of them were measured respectively. Results showed that PAW‐B exhibited stronger disinfection efficiency than PAW‐A, which associated with ORP conductivity, but not pH value, temperature, H 2 O , NO 3 − or . Furthermore, cell membrane integrity potential S....
Elucidating the pathways that lead to vasculogenic cells, and being able identify their progenitors lineage-restricted is critical establishment of human pluripotent stem cell (hPSC) models for vascular diseases development therapies. Here, we find mesoderm-derived pericytes (PCs) smooth muscle cells (SMCs) originate from a clonal mesenchymal progenitor mesenchymoangioblast (MB). In clonogenic cultures, MBs differentiate into primitive PDGFRβ+CD271+CD73− progenitors, which give rise...
Disruptions in mitochondrial dynamics may contribute to the selective degeneration of dopamine (DA) neurons Parkinson's disease (PD). However, little is known about normal functions these neurons, especially axons where begins, and this makes it difficult understand process. To study one aspect dynamics-mitochondrial fission-in mouse DA we deleted central fission protein dynamin-related 1 (Drp1). Drp1 loss rapidly eliminates terminals caudate-putamen causes cell bodies midbrain degenerate...
Macrophages armed with chimeric antigen receptors (CARs) provide a potent new option for treating solid tumors. However, genetic engineering and scalable production of somatic macrophages remains significant challenges. Here, we used CRISPR-Cas9 gene editing methods to integrate an anti-GD2 CAR into the AAVS1 locus human pluripotent stem cells (hPSCs). We then established serum- feeder-free differentiation protocol generating (CAR-Ms) through arterial endothelial-to-hematopoietic transition...
Abstract A direct‐current, cold‐atmospheric‐pressure air plasma microjet (PMJ) sustained in a quasi‐steady gas cavity liquid medium is used to inactivate Staphylococcus aureus ( S. ) suspended the liquid. The temperature and pH value of change steady‐state values about 40 °C 3.0–4.5, respectively, after 10 min treatment. decrease attributed reaction NO x produced with water at gas–liquid interface. concentrations are measured be 37 mg · L −1 21 , 20 Effective inactivation found start...
Ar/O2 (2%) cold plasma microjet was used to create plasma-activated water (PAW). The disinfection efficacy of PAW against Staphylococcus aureus showed that can effectively disinfect bacteria. Optical emission spectra and oxidation reduction potential results demonstrated the inactivation is attributed oxidative stress induced by reactive oxygen species in PAW. Moreover, X-ray photoelectron spectroscopy, atomic absorption spectrometry, transmission electron microscopy suggested chemical state...
Disinfection of hazardous microorganisms that may challenge environmental safety is a crucial issue for economic and public health. Here, we explore the potential novel electrochemical disinfectant named plasma activated water (PAW), which was generated by nonthermal plasma, inactivating Staphylococcus aureus (S. aureus). Meanwhile, influence bovine serum albumin (BSA) on PAW disinfection efficacy investigated. In presence BSA, treatments achieved reduction S. ranging from 2.1 to 5.5 Log,...
Abstract Hydroxyl radical ( • OH) and singlet oxygen 1 O 2 ) were detected by electron spin resonance (ESR) spectroscopy in a direct current He/O (2%) non‐thermal plasma microjet‐water system. ${}^{ \bullet }{\rm O}_{{\rm 2}}^{- } $ is shown to be the precursor of OH. The concentrations OH are evaluated around 6 × 10 −4 1.2 −5 M, respectively. survival rates S. aureus exposed for 20 s ml H O, SOD (100 U, scavenging ), D ‐Man (0.15 M , OH), L ‐His solutions 0.7, 1.6, 13.4, 40.9%,...
Type 2 diabetes mellitus (T2DM) alters brain function and manifests as atrophy. Intranasal insulin has emerged a promising intervention for treatment of cognitive impairment. We evaluated the acute effects intranasal on resting-state functional connectivity in older adults with T2DM. This proof-of-concept, randomized, double-blind, placebo-controlled study single 40 IU dose or saline 14 diabetic control subjects. Resting-state between hippocampal region default mode network (DMN) was...
Mitochondria in many types of cells are dynamically interconnected through constant fusion and fission, allowing for exchange mitochondrial contents repair damaged mitochondria. However, constrained by the myofibril lattice, ∼6,000 mitochondria adult mammalian cardiomyocyte display little motility, it is unclear how, if at all, they communicate with each other. By means target-expressing photoactivatable green fluorescent protein (PAGFP) matrix or on outer membrane, we demonstrated that...
Here, nonthermal plasma generated by a dielectric barrier discharge (DBD) system was applied to inactivating aerosolized Bacillus subtilis cells and Pseudomonas fluorescens as well indoor outdoor bioaerosols. The culturability, viability, diversity losses of the microorganisms in air samples treated for 0.06-0.12 s were studied using culturing, DNA stain polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) methods. In addition, viable fraction bacterial aerosols with...