A5020943599- Microbial Inactivation Methods
- Plasma Applications and Diagnostics
- Electrohydrodynamics and Fluid Dynamics
- Microfluidic and Bio-sensing Technologies
- Plasma Diagnostics and Applications
- Pulsed Power Technology Applications
- Magnetic and Electromagnetic Effects
- Multicomponent Synthesis of Heterocycles
- Power Transformer Diagnostics and Insulation
- Neuroscience and Neural Engineering
- Electrostatic Discharge in Electronics
- Surface Modification and Superhydrophobicity
- Chemical Synthesis and Analysis
- Algal biology and biofuel production
- Laser-induced spectroscopy and plasma
- Aerosol Filtration and Electrostatic Precipitation
- Advanced oxidation water treatment
- Bacillus and Francisella bacterial research
- Pharmaceutical and Antibiotic Environmental Impacts
- Electrical and Bioimpedance Tomography
- Listeria monocytogenes in Food Safety
- Ultrasound and Cavitation Phenomena
- Body Composition Measurement Techniques
- Radiation Effects and Dosimetry
- Catalytic C–H Functionalization Methods
Leibniz Institute for Plasma Science and Technology
2015-2024
Queen Mary University of London
2024
Xi'an Jiaotong University
2024
University of Rostock
2019-2023
Suzhou Institute of Biomedical Engineering and Technology
2021
Chinese Academy of Sciences
2021
Leibniz Association
2013
Old Dominion University
2003-2012
Dominion University College
2012
BioElectronics (United States)
2007-2009
By flowing atmospheric pressure air through a direct current powered microhollow cathode discharge, we were able to generate 2cm long plasma jet. With increasing flow rate, the becomes turbulent and temperatures of jet are reduced values close room temperature. Utilizing jet, yeast grown on agar can be eradicated with treatment only few seconds. Conversely, animal studies show no skin damage even exposures ten times longer than needed for pathogen extermination. This cold provides an...
An electrical model for biological cells predicts that pulses with durations shorter than the charging time of outer membrane, there is an increasing probability electric field interactions intracellular structures. Experimental studies in which human were exposed to pulsed fields up 300-kV/cm amplitude, as short 10 ns, have confirmed this hypothesis. The observed effects include breaching granule membranes without permanent damage cell abrupt rises free calcium levels, and enhanced...
Electrical models for biological cells predict that reducing the duration of applied electrical pulses to values below charging time outer cell membrane (which is on order 100 ns mammalian cells) causes a strong increase in probability electric field interactions with intracellular structures due displacement currents. For amplitudes exceeding MV/m, such are also expected allow access interior through conduction currents flowing permeabilized plasma membrane. In both cases, limiting...
The application of gas discharge plasmas has assumed an important place in many manufacturing processes. Plasma methods contribute significantly to the economic prosperity industrialized societies. However, plasma is mainly enabling method and therefore its role remains often hidden. Hence success technologies described for different examples commercial areas. From these emerging applications, potential discussed. Economic trends are anticipated together with research needs. community...
Abstract The barrier function of plasma membrane in nsPEF‐exposed mammalian cells was examined using whole‐cell patch‐clamp techniques. A specialized setup for nsPEF exposure individual culture developed and characterized artifact‐free compatibility with the method. For first time, our study provides experimental evidence that even a single 60‐ns pulse at 12 kV/cm can cause profound long‐lasting (minutes) reduction cell resistance ( R m ), accompanied by loss potential. measured GH3, PC‐12,...
Experimental results on the inception and propagation of streamers in water generated under application high electric fields are reviewed. Characteristic parameters, such as breakdown voltage, polarity applied velocities other phenomenological features, compared with similar phenomena dielectric liquids gases. Consequently, parameters that expected to influence development discussed respect analogous well-established models theories for related mechanisms Most data support notion an initial...
Abstract We have discovered a new, ultrafast therapy for treating skin cancer that is extremely effective with total electric field exposure time of only 180 μsec. The application 300 high‐voltage (40 kV/cm), ultrashort (300 nsec) electrical pulses to murine melanomas in vivo triggers both necrosis and apoptosis, resulting complete tumor remission within an average 47 days the 17 animals treated. None these recurred during 4‐month period after initial melanoma had disappeared. These generate...
Modeling and experimental studies have shown that pulsed electric fields of nanosecond duration megavolt per meter amplitude affect subcellular structures but do not lead to the formation large pores in outer membrane. This "intracellular electromanipulation" requires use pulse generators which provide extremely high power low energy pulses. In this study, we describe concept required sources, their design, operation, necessary diagnostics. Two types based on Blumlein line principle been...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Nanosecond electrical pulses have been successfully used to treat melanoma tumors by using needle arrays as pulse delivery systems. Reducing the duration of intense electric field from nanoseconds into subnanosecond range will allow us use wideband antennas deliver electromagnetic fields tissue with a spatial resolution in centimeter range. To explore biological effect pulses, we developed...
Electroactive hydrogels can be used to influence cell response and maturation by electrical stimulation. However, hydrogel formulations which are 3D printable, electroactive, cytocompatible, allow adhesion, remain a challenge in the design of such stimuli-responsive biomaterials for tissue engineering. Here, combination pyrrole with high gelatin-content oxidized alginate-gelatin (ADA-GEL) is reported, offering 3D-printability precursors prepare cytocompatible electrically conductive...
Multicomponent reactions (MCRs) are not only a powerful tool for drug discovery, they also represent an excellent methodology synthesis rationalization. Here we wish to illustrate the potential of MCRs in production generic drugs by synthesizing, racemic form, antiplatelet agent clopidogrel and non-steroidal antiandrogen bicalutamide, using Ugi, Petasis Passerini reactions.
Experimental and modeling studies on electrical breakdown in water submillimeter gaps between pin plane electrodes have been performed. Prebreakdown, recovery of the were studied experimentally by using optical diagnostics with a temporal resolution order one nanosecond. By Mach–Zehnder interferometry, electric field distribution prebreakdown phase was determined means Kerr effect. Electric fields values excess computed fields, which reach >4 MV cm−1 for applied pulses 20 ns duration,...
Many effective anti-cancer strategies target apoptosis and angiogenesis mechanisms. Applications of non-ionizing, nanosecond pulsed electric fields (nsPEFs) induce in vitro eliminate cancer vivo; however vivo mechanisms require closer analysis. These studies investigate nsPEF-induced anti-angiogenesis examined by fluorescent microscopy, immunoblots, morphology. Six hours after treatment with one hundred 300 ns pulses at 40 kV/cm, cells transiently expressed active caspases indicating that...
Novel therapies are needed for treating hepatocellular carcinoma (HCC) without recurrence in a single procedure. In this work we evaluated anti-neoplastic effects of pulse power ablation (PPA) with nanosecond pulsed electric fields (nsPEFs), non-thermal, non-drug, local, regional method and investigated its molecular mechanisms tumor vivo. An ectopic model was established using C57BL/6 mice Hepa1-6 cells. Pulses durations 30 or 100 ns fast rise times were delivered by needle ring electrode...
Abstract Physical mechanisms for streamer initiation and electrical breakdown in water are discussed. The focus is on various processes that could lead to the inception propagation of streamers water. details associated with observed disparities at anode versus cathode, differences luminosity, variations speeds Creation a localized low‐density region near site field enhancement shown be essential initiation. Finally, use trigatron‐type electrically triggered switch triple‐point geometry...