A5079075921- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Hydrogels: synthesis, properties, applications
- Titanium Alloys Microstructure and Properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- biodegradable polymer synthesis and properties
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Cell Image Analysis Techniques
- Graphene and Nanomaterials Applications
- Facial Trauma and Fracture Management
- Endodontics and Root Canal Treatments
- Osteoarthritis Treatment and Mechanisms
- Calcium Carbonate Crystallization and Inhibition
- Cellular Mechanics and Interactions
- Laser-Ablation Synthesis of Nanoparticles
- Magnesium Alloys: Properties and Applications
- Periodontal Regeneration and Treatments
- Bone and Dental Protein Studies
- Planarian Biology and Electrostimulation
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Materials Science & Engineering
2019
Universitätsklinikum Erlangen
2018
BioCer Entwicklungs (Germany)
2007-2017
Katholisches Kinderkrankenhaus Wilhelmstift
2017
University of Bayreuth
2005-2011
Microencapsulation of cells by using biodegradable hydrogels offers numerous attractive features for a variety biomedical applications including tissue engineering. This study highlights the fabrication microcapsules from an alginate–gelatin crosslinked hydrogel (ADA–GEL) and presents evaluation physico-chemical properties new which are relevant designing suitable Alginate di-aldehyde (ADA) was synthesized periodate oxidation alginate facilitates crosslinking with gelatin through Schiff's...
Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked (ADA-GEL) hydrogel was synthesized through covalent crosslinking di-aldehyde (ADA) with gelatin that supported cell attachment, spreading and proliferation. This study highlights evaluation physico-chemical properties ADA-GEL hydrogels different compositions compared in form films. Moreover, vitro on investigated by using normal human dermal fibroblasts. Viability, proliferation...
Using additive manufacturing to create hydrogel scaffolds which incorporate homogeneously distributed, immobilized cells in the context of biofabrication approaches represents an emerging and expanding field tissue engineering. Applying hydrogels for must consider material processing properties as well their influence on cells. In this work alginate-dialdehyde (ADA), a partially oxidized alginate, was used basic improve physico-chemical cell immobilization. At first, ability gel using...
Various biomaterials have been developed for the use as bone substitutes defects. To optimize their integration and functionality, they should be adapted to individual defect. Rapid prototyping is a manufacturing method tailor materials 3D geometry of Especially printing allows manufacture implants, shape which can designed fit defect using anatomical information obtained from patient. calcium phosphates, are well established substitutes, involves sintering step after gluing granules...
Bone substitute material properties such as granule size, macroporosity, microporosity and shape have been shown to influence the cellular inflammatory response a bone material. Keeping these parameters constant, present study analyzed in vivo tissue reaction three materials (granules) with different chemical compositions (hydroxyapatite (HA), beta-tricalcium phosphate (TCP) mixture of both HA/TCP ratio 60/40 wt%). Using subcutaneous implantation model Wistar rats for up 30 days, reactions,...
The combination of biodegradable polymers and bioactive inorganic materials is being widely used for designing bone tissue engineering scaffolds. Here we report a composite hydrogel system composed glass incorporated in covalently cross-linked oxidized alginate-gelatin (ADA-GEL) porous scaffolds with tunable stiffness degradability using freeze-drying technique. Because the presence glass, cross-linking kinetic degree hydrogels are significantly increased, which main factor measured enhanced...
In addition to good mechanical properties needed for three-dimensional tissue engineering, the combination of alginate dialdehyde, gelatin and nano-scaled bioactive glass (45S5) is supposed combine excellent cellular adhesion, proliferation differentiation properties, biocompatibility predictable degradation rates. The goal this study was evaluate in vitro vivo as a first step on way its use scaffold bone engineering. evaluation showed cell adherence marrow derived mesenchymal stem cells...
Achieving cell spreading and proliferation inside hydrogels that are compatible with microencapsulation technology represents a major challenge for tissue engineering scaffolding the development of three-dimensional culture models. In this study, microcapsules 650-900 μm in diameter were fabricated from oxidized alginate covalently cross-linked gelatine (AlGel). Schiff's base bond formed AlGel, detected by Fourier transform infrared spectroscopy, which confirmed cross-linking gelatine....
The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not surprise that bone-related research, especially the field tissue engineering, issue medical research. Researchers worldwide are searching for missing link engineering graft materials mimic bones, and foster osteogenesis remodeling. One approach combination additive manufacturing technology with smart additionally electrically active biomaterials. In this study, we performed three-dimensional...
Biofabrication can be a tool to three-dimensionally (3D) print muscle cells embedded inside hydrogel biomaterials, ultimately aiming mimic the complexity of native tissue and create in-vitro analogues for advanced repair therapies drug testing. However, 3D high cell alignment synchronous contraction, effect biofabrication process parameters on myoblast growth has understood. A suitable biomaterial matrix is required provide printability as well degradation space proliferation, remodelling...
Many different biofabrication approaches as well a variety of bioinks have been developed by researchers working in the field tissue engineering. A main challenge for often remains difficulty to achieve shape fidelity after printing. In order overcome this issue, homogeneous pre-crosslinking technique, which is universally applicable all alginate-based materials, was developed. study, Young's Modulus post-crosslinking selected hydrogels, chemical characterization alginate terms M/G ratio and...
The treatment of critical size bone defects, for example resulting from large tumor resections, still remains a challenge in clinical practice. It has been demonstrated that the gold standard based on auto- and allografts can provide aid some cases. However, development patient specific 3D printed implants modern biomaterial-based tissue engineering (TE) strategies, avoiding requirement harvesting donor site, promises to be next generation healing. We present PLA-Bioactive glass (BG)...
In 3D bioprinting, bioinks with high concentrations of polymeric materials are frequently used to enable fabrication cell-hydrogel constructs sufficient stability. However, this is often associated restricted cell bioactivity and an inhomogeneous distribution newly produced extracellular matrix (ECM). Therefore, study investigates bioink compositions based on hyaluronic acid (HA), attractive material for cartilage regeneration, which allow reduction polymer content. Thiolated HA...
The objective of this study was to produce antibacterial poly(ε-caprolactone) (PCL)-gelatin (GEL) electrospun nanofiber mats containing clove essential oil (CLV) using glacial acetic acid (GAA) as a "benign" (non-toxic) solvent. addition CLV increased the fiber diameter from 241 ± 96 305 82 nm. Aside this, wettability PCL-GEL by CLV. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed presence CLV, and actual content determined gas chromatography-mass spectrometry (GC-MS). Our...
Electroactive hydrogels can be used to influence cell response and maturation by electrical stimulation. However, hydrogel formulations which are 3D printable, electroactive, cytocompatible, allow adhesion, remain a challenge in the design of such stimuli-responsive biomaterials for tissue engineering. Here, combination pyrrole with high gelatin-content oxidized alginate-gelatin (ADA-GEL) is reported, offering 3D-printability precursors prepare cytocompatible electrically conductive...
Hydrogels that allow for the successful long-term in vitro culture of cell-biomaterial systems to enable maturation tissue engineering constructs are highly relevant regenerative medicine. Naturally derived polysaccharide-based hydrogels promise be one material group with enough versatility and chemical functionalization capability tackle challenges associated cell culture. We report a marine oxidized alginate, alginate dialdehyde (ADA), gelatin (GEL) system (ADA-GEL), which is cross-linked...