A5011795162- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Acute Myeloid Leukemia Research
- Characterization and Applications of Magnetic Nanoparticles
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Hematopoietic Stem Cell Transplantation
- Dyeing and Modifying Textile Fibers
- Chronic Lymphocytic Leukemia Research
- Mycobacterium research and diagnosis
- Chronic Myeloid Leukemia Treatments
- Innovations in Concrete and Construction Materials
- Vascular Tumors and Angiosarcomas
- biodegradable polymer synthesis and properties
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Cardiac Arrest and Resuscitation
Universitätsklinikum Erlangen
2014-2021
Else Kröner-Fresenius-Stiftung
2015-2021
University of Malaya
2021
Post Graduate Institute of Medical Education and Research
2021
Universiti Teknologi Brunei
2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2020
Army Hospital Research and Referral
2018
Heinrich Heine University Düsseldorf
2008-2011
Command Hospital
2008
Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked (ADA-GEL) hydrogel was synthesized through covalent crosslinking di-aldehyde (ADA) with gelatin that supported cell attachment, spreading and proliferation. This study highlights evaluation physico-chemical properties ADA-GEL hydrogels different compositions compared in form films. Moreover, vitro on investigated by using normal human dermal fibroblasts. Viability, proliferation...
Novel hybrid hydrogels based on alginate and keratin were successfully produced for the first time. The self-assembly properties of keratin, its ability to mimic extracellular matrix combined with excellent chemical mechanical stability biocompatibility produce 2D 3D hydrogels. These prepared using two different approaches: sonication, obtain hydrogels, a pressure-driven extrusion technique All results indicated that composition had significant effect their physical properties, they can...
Rapid endothelialization helps overcome the limitations of small-diameter vascular grafts. To develop biomimetic non-thrombogenic coatings supporting endothelialization, medical-grade polyurethane (PU) nanofibrous mats and tubular scaffolds with a diameter below 6 mm prepared by solution blow spinning were coated polydopamine (PDA), or PDA gelatin (PDA/Gel). The characterized scanning electron microscopy, porosity measurement, tensile testing, wettability, Fourier Transform Infrared...
Abstract The composites based on polylactide (PLA) and poly (3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHBV) with the addition of antibacterial particles: silver (Ag) copper oxide (CuO) are characterized. Basic mechanical properties biodegradation processes, as well biocompatibility materials human cells determined. Ag or CuO to polymers do not significantly affect their properties, flammability, rate. However, several differences between base observed. PLA‐based have higher tensile impact...
Due to the presence of tripeptide arginine–glycine–aspartic acid, gelatin is considered a very promising additive material improve cytocompatibility alginate-based hydrogels. Two different strategies, physical blending and chemical crosslinking with gelatin, are used in this study modify alginate hydrogel. As intermolecular interactions between polysaccharide protein resulting physically blended chemically crosslinked hydrogels different, significant differences properties these hydrogel...
Pegylated granulocyte colony-stimulating factor (G-CSF) has recently been introduced as a new compound for mobilization of CD34(+) hematopoietic stem and progenitor cells. In this study, we compared the molecular functional characteristics cells mobilized by pegylated G-CSF with those unconjugated G-CSF.Gene expression immunomagnetically enriched from leukapheresis products patients who were given pegylated-G-CSF or was analyzed using Affymetrix HG Focus microarrays quantitative reverse...
Nanomedicine offers tremendous opportunities for the development of novel therapeutic and diagnostic tools. During last decades, extensive knowledge was gained about stabilizing coating nanoparticles, their functionalization drug binding release possible strategies therapies diagnostics different diseases. Most recently, more emphasis has been placed on nanotoxicology nanosafety aspects. The section experimental oncology nanomedicine developed a concept translating this into clinical...
Developing matrices biocompatible with vascular cells is one of the most challenging tasks in tissue engineering. Here, we compared growth on different hydrogels as potential materials for bioplotting tissue. Formulations containing alginate solution (Alg, 2%, w/v) blended protein solutions (silk fibroin, gelatin, keratin, or elastin) at 1% w/v were prepared. Human umbilical vein endothelial (ECs), smooth muscle (SMCs), and fibroblasts cultivated 7 days. Cell number morphology was visualised...
To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription bone marrow derived CD34+ cells from patients with non-5q- syndrome and found a reduced expression 51 72 (71%) patients. MDS an intermediate-1 risk (INT-1) score according to international prognostic scoring system low had superior median overall survival not reached versus 25 months compared INT-1 high (p=0.0249). Using multivariate analysis, status was confirmed as...
Novel composite hydrogels based on the combination of alginate (Alg), soy protein isolate (SPI) and bioactive glass (BG) nanoparticles were developed for soft tissue engineering. Human umbilical vein endothelial cells (HUVEC) normal human dermal fibroblasts cultivated 7, 14 21 days. Cell morphology was visualized using fluorescent staining at Days 7 fibroblast HUVEC. Metabolic activity analyzed a colorimetric assay (water soluble tetrazolium (WST) assay). Compared to pure Alg, Alg/SPI...
Tissue-engineered scaffolds require an effective colonization with cells. Superparamagnetic iron oxide nanoparticles (SPIONs) can enhance cell adhesion to matrices by magnetic seeding. We investigated the possibility of improving attachment and growth on different alginate-based hydrogels using fibroblasts endothelial cells (ECs) loaded SPIONs. Hydrogels containing pure alginate (Alg), dialdehyde crosslinked gelatin (ADA-G) Alg blended G or silk fibroin (SF) were prepared. Endothelial SPIONs...
Cell-sheet technology is a well-known method by which cells are grown on thermoswitchable substrates that become nonadhesive upon cooling, such complete layer of adherent cells, along with the produced extracellular matrix, detaches as sheet. Polymers exhibit lower critical solution temperature (LCST) below physiological in water, commonly poly(N-isopropylacrylamide) (PNIPAM), covalently grafted or, for block copolymers, physisorbed onto monomolecular thin film to achieve this. Consequently,...
Abstract Breast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, key risk factors. The use of gene expression assays for early stage already common practice. These tests have found place in stratifying the group I–II breast cancers recurrence, predicting chemotherapy response, cancer-related mortality. Most guidelines hormone receptor (HR)–positive recommend addition adjuvant most women, leading to overtreatment, which causes...
Abstract In this research, the tensile strength behaviour of 3D-printed ABS polymer was studied. particular, following printing parameters were investigated i.e. angle orientation 0°, 30° and 45°, layer thickness 0.2 mm, 0.3 mm 0.4 speeds 60 mm/s, 40 mm/s 20 mm/s. The samples subjected to loading in order determine stress-strain curve, UTS elastic modulus. results indicated that speed has no major impact on samples. On other hand, gave highest stiffness, whereas 45° strength. However,...