A5068621433- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Bone fractures and treatments
- Tissue Engineering and Regenerative Medicine
- Surgical site infection prevention
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Reconstructive Facial Surgery Techniques
- Surgical Sutures and Adhesives
- Breast Implant and Reconstruction
- Nerve Injury and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Periodontal Regeneration and Treatments
- Angiogenesis and VEGF in Cancer
- Peripheral Nerve Disorders
- Mesenchymal stem cell research
- Organ and Tissue Transplantation Research
- Body Contouring and Surgery
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Anatomy and Medical Technology
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
Heidelberg University
2016-2025
Ludwigshafen University of Business and Society
2016-2025
Klinikum Ludwigshafen
2016-2025
University Hospital Heidelberg
2016-2025
Berufsgenossenschaftliche Unfallklinik Ludwigshafen
2015-2024
Creative Commons
2018-2024
Chirurgische Universitätsklinik Heidelberg
2024
Heidelberg University
2013-2023
University of Wisconsin–Madison
2023
BG Klinik Tübingen
2023
Despite well-established bone-grafting techniques, large bone defects still represent a challenge for orthopaedic and reconstructive surgeons. Efforts have therefore been made to develop osteoconductive, osteoinductive osteogenic bone-replacement systems. According its original definition, tissue engineering is an 'interdisciplinary field that applies the principles of life sciences toward development biological substitutes restore, maintain, or improve function'. It based on understanding...
Introduction: Vascularization remains an obstacle to engineering of larger volume bone tissues. Our aim was induce axial vascularization in a processed bovine cancellous (PBCB) matrix using arteriovenous (AV) loop (artery, vein graft, and vein). Methods: Custom-made PBCB discs (9×5 mm) were implanted into rats. In group A (n= 19), the matrices inserted microsurgically constructed AV loops between femoral vessels graft from contralateral side. B (n = there no vascular carrier. The encased...
Tissue Engineering (TE) and Regenerative Medicine (RM) have gained much popularity because of the tremendous prospects for care patients with tissue organ defects. To overcome common problem donor-site morbidity standard autologous bone grafts, we successfully combined engineering techniques first time arteriovenous loop model to generate vascularized large grafts. We present two cases defects after debridement an osteomyelitis. One was localized in radius one tibia. For osseus...
In addition to good mechanical properties needed for three-dimensional tissue engineering, the combination of alginate dialdehyde, gelatin and nano-scaled bioactive glass (45S5) is supposed combine excellent cellular adhesion, proliferation differentiation properties, biocompatibility predictable degradation rates. The goal this study was evaluate in vitro vivo as a first step on way its use scaffold bone engineering. evaluation showed cell adherence marrow derived mesenchymal stem cells...
Bromelain-based Enzymatic Debridement has been introduced as an additional concept to the burn surgeon's armamentarium and is best indicated for mid-to deep dermal burns with mixed patterns. Increasing evidence published focusing on special regions settings well limitations of improve patient care. To better guide in view increasing experience, there a need update formerly consensus guidelines user-orientated recommendations, which were last produced 2017. A multi-professional expert panel...
Background Peripheral nerve injury in the upper extremity is linked to high socioeconomic burden, yet cost-analyses are rare and from small cohorts. The objective of this study was determine costs long-term effects peripheral injuries Germany. Methods We analyzed data 250 patients with 268 work-related acute treatment follow-up on rehabilitation, sick-leave disability-pension. Results Patients were average 39.9±14.2 years old, male (85%) mean inpatient 7±6 days. Location 8% (N = 19) proximal...
Bioactive glass (BG) scaffolds are being investigated for bone tissue engineering applications because of their osteoconductive and angiogenic nature. However, to increase the in vivo performance scaffold, including enhancing angiogenetic growth into scaffolds, some researchers use different modifications scaffold addition inorganic ionic components basic BG composition. In this study, we vitro biocompatibility bioactivity Cu2+-doped derived either BMSC (bone-marrow mesenchymal stem...
Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications post-mastectomy radiation therapy (PMRT) have broadened. The aim of Oncoplastic Breast Consortium initiative was to address relevant questions arising this clinically challenging scenario.A large global panel oncologic, oncoplastic reconstructive surgeons, patient advocates oncologists developed recommendations clinical practice in an iterative...
Background: The potential of robot-assisted surgery in plastic and reconstructive remains to be established, especially free tissue transfer. This prospective study aimed present our experience findings from the first 50 consecutive cases microsurgery using Symani surgical system. Methods: A database was maintained, recording patient demographics details for all a large academic institution. All surgeons underwent an intensive training program with Results: total patients who microsurgical...
One of the major challenges in tissue engineering bone substitutes remains vascularization transplant. We have developed a three-dimensional collagen-based coculture system to assess interactions between human endothelial cells (hECs) and osteoblasts (hOBs) vitro. Human umbilical vein (HUVECs) were grown as multicellular spheroids seeded collagen matrix sprouting spheroids, that is, formation tubelike structures resembling early capillaries. Direct cell contact hOBs HUVECs was established by...
Soft-tissue defects of the foot and lower leg caused by traumatic injury, tumor ablation, or infection associated with osteomyelitis often require coverage flaps. One excellent option for reconstruction these is distally based neurofasciocutaneous sural flap. It allows rapid reliable from distal third to forefoot without significant functional donor-site morbidity. However, maximal size flap limited delicate perfusion arterial network superficial sensory nerve. Delay procedures may increase...