Christoph Hirche

ORCID: 0000-0001-6112-8671
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About
Contact & Profiles
Research Areas
  • Reconstructive Surgery and Microvascular Techniques
  • Burn Injury Management and Outcomes
  • Wound Healing and Treatments
  • Orthopedic Surgery and Rehabilitation
  • Bone fractures and treatments
  • Surgical Sutures and Adhesives
  • Surgical site infection prevention
  • Breast Implant and Reconstruction
  • Lymphatic System and Diseases
  • Breast Cancer Treatment Studies
  • Elbow and Forearm Trauma Treatment
  • Reconstructive Facial Surgery Techniques
  • Body Contouring and Surgery
  • Nerve Injury and Rehabilitation
  • Peripheral Nerve Disorders
  • Colorectal Cancer Surgical Treatments
  • Sarcoma Diagnosis and Treatment
  • Disaster Response and Management
  • Colorectal and Anal Carcinomas
  • Vascular Procedures and Complications
  • Dermatologic Treatments and Research
  • Breast Lesions and Carcinomas
  • Injury Epidemiology and Prevention
  • Quantum Information and Cryptography
  • Diagnosis and Treatment of Venous Diseases

Berufsgenossenschaftliche Unfallklinik Frankfurt am Main
2021-2025

Goethe University Frankfurt
2021-2025

Heidelberg University
2015-2024

Berufsgenossenschaftliche Unfallklinik Ludwigshafen
2014-2024

Mayo Clinic
2024

Ludwigshafen University of Business and Society
2014-2023

Klinikum Ludwigshafen
2014-2023

Technical University of Munich
2023

Centre for Quantum Technologies
2023

National University of Singapore
2023

Sentinel lymph node (SLN) biopsy with radioisotope and blue dye has been used successfully for axillary staging in breast cancer. This study evaluated the feasibility of fluorescence detection SLNs indocyanine green (ICG) lymphatic mapping SLN biopsy.Thirty women cancer had a periareolar injection ICG using near-infrared camera. Twenty also received (99m)Tc-labelled sulphur radiocolloid scintigraphy. All patients underwent dissection. Detection rate sensitivity both methods were...

10.1002/bjs.6721 article EN British journal of surgery 2009-10-21

Abstract The use of negative pressure wound therapy with instillation and dwell time (NPWTi‐d) has gained wider adoption interest due in part to the increasing complexity wounds patient conditions. Best practices for NPWTi‐d have shifted recent years based on a growing body evidence expanded worldwide experience technology. To better guide all dressing setting configurations, as well solutions, there is need publish updated international consensus guidelines, which were last produced over 6...

10.1111/iwj.13254 article EN cc-by-nc International Wound Journal 2019-10-30

Bromelain-based Enzymatic Debridement has been introduced as an additional concept to the burn surgeon's armamentarium and is best indicated for mid-to deep dermal burns with mixed patterns. Increasing evidence published focusing on special regions settings well limitations of improve patient care. To better guide in view increasing experience, there a need update formerly consensus guidelines user-orientated recommendations, which were last produced 2017. A multi-professional expert panel...

10.1016/j.burns.2020.03.002 article EN cc-by-nc-nd Burns 2020-03-30

The optimal time for flap anastomosis to an arteriovenous loop remains controversial. Whether perforator flaps and axially vascularized muscle or fasciocutaneous lead comparable outcomes in conjunction with loops has not been investigated.Medical records from 103 patients undergoing reconstruction (76 one-stage 27 two-stage) between 2007 2017 were reviewed. Postoperative compared one- two-stage reconstructions different types of free flaps.Rates thrombosis, major wound complications, failure...

10.1097/prs.0000000000005386 article EN Plastic & Reconstructive Surgery 2019-01-24

ABSTRACT Background Malignant tumors release growth factors, promoting lymphangiogenesis in primary and draining sentinel lymph nodes, ultimately facilitating node metastasis. As a malignant lymphatic tumor entity, lymphangiosarcomas are characterized by low survival rates limited treatment options. The transcription factor SOX18 plays crucial role both endothelial cell differentiation cancer‐induced lymphangiogenesis. Aims In this vitro study, we investigated the potential therapeutic...

10.1002/cnr2.70110 article EN cc-by Cancer Reports 2025-01-01

Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...

10.1136/bmjopen-2024-090662 article EN cc-by-nc-nd BMJ Open 2025-02-01

Background. Visualization of the lymphatic system is challenging. Lymphatic imaging a crucial diagnostic tool for benign and malignant pathologies. Fluorescence-guided allows selective mapping sentinel lymph node (SLN) identification. There are few fluorescence systems, but some drawbacks remain due to technical ergonomic aspects. The aim this study was evaluate feasibility new Fluobeam 800 system. Methods. After approval by ethics committee, evaluated lymphography SLN biopsy in an animal...

10.1177/1553350612468962 article EN Surgical Innovation 2012-12-27

Near-infrared indocyanine green video angiography (ICG-NIR-VA) has been introduced for free-flap surgery and may provide intraoperative flap designing as well postoperative monitoring. Nevertheless, the technique not established in clinical routine because of controversy over benefits. Improved technical features novel Visionsense ICG-NIR-VA system are promising to revisit field application. It a unique real-time fusion image simultaneous NIR white light visualization, with highlighted...

10.1177/1553350615610651 article EN Surgical Innovation 2015-10-15

Background Vascular occlusion after free flap surgery has become a rare complication but still poses major challenge. It necessitates urgent re-exploration, the logistic challenge to provide sufficient resources for emergency intervention remains. The aim of this study was analyze long-term outcome successful lower extremity salvage. Methods A single-center retrospective including follow-up approved by local ethics committee. From January 1999 December 2010, total 581 flaps were performed...

10.1055/s-0038-1675146 article EN Journal of Reconstructive Microsurgery 2018-10-16

Abstract Background Reliable perfusion of the distal portions free flaps is decisive for reconstructive success. Indocyanine green near-infrared video angiography (ICG-NIR-VA) has been adopted objective assessment flap tissue but thus far not used on a routine basis. Therefore, we investigated its intraoperative impact decision-making and postoperative outcome. Methods From January 2017 to June 2019, 88 consecutive adipo- or fasciocutaneus were performed in conjunction with ICG-NIR-VA. Free...

10.1055/s-0040-1710552 article EN Journal of Reconstructive Microsurgery 2020-05-14
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