A5034133648- Reconstructive Surgery and Microvascular Techniques
- Mesenchymal stem cell research
- Breast Implant and Reconstruction
- Orthopedic Surgery and Rehabilitation
- Body Contouring and Surgery
- Periodontal Regeneration and Treatments
- Bone fractures and treatments
- Reconstructive Facial Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- CAR-T cell therapy research
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Orthopedic Infections and Treatments
- Pressure Ulcer Prevention and Management
- Osteoarthritis Treatment and Mechanisms
- Facial Rejuvenation and Surgery Techniques
- Surgical site infection prevention
- Breast Cancer Treatment Studies
- Diabetic Foot Ulcer Assessment and Management
- Digital Imaging in Medicine
- Body Image and Dysmorphia Studies
- Nerve Injury and Rehabilitation
- Virus-based gene therapy research
University Hospital of Basel
2016-2025
University of Basel
2016-2025
University of Siegen
2025
Creative Commons
2016-2023
Otto-von-Guericke University Magdeburg
2023
University Children’s Hospital Basel
2022
Swiss Paraplegic Center
2013-2022
Hôpital Beau-Séjour
2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
1992-2020
Turku University Hospital
2020
Treatment of large defects requires the harvest fresh living bone from iliac crest. Harvest this limited supply is accompanied by extreme pain and morbidity. This has prompted exploration other alternatives to generate new using traditional principles tissue engineering, wherein harvested cells are combined with porous scaffolds stimulated exogenous mitogens morphogens in vitro and/or vivo. We now show that volumes can be engineered a predictable manner, without need for cell transplantation...
Abstract Objective To test the hypothesis that engineered cartilage can provide a mechanically functional template capable of undergoing orderly remodeling during repair large osteochondral defects in adult rabbits, as assessed by quantitative structural and methods. Methods Engineered generated vitro from chondrocytes cultured on biodegradable scaffold was sutured to subchondral support resulting composite press‐fitted into 7‐mm long, 5‐mm wide, deep defect rabbit knee joint. Defects left...
Despite well-established bone-grafting techniques, large bone defects still represent a challenge for orthopaedic and reconstructive surgeons. Efforts have therefore been made to develop osteoconductive, osteoinductive osteogenic bone-replacement systems. According its original definition, tissue engineering is an 'interdisciplinary field that applies the principles of life sciences toward development biological substitutes restore, maintain, or improve function'. It based on understanding...
VEGF induces normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell vivo. This transition depends balance between VEGF-induced endothelial stimulation and PDGF-BB-mediated pericyte recruitment, co-expression of PDGF-BB normalizes despite high doses. We recently found that over-expression skeletal muscle through an initial circumferential vascular enlargement followed by longitudinal splitting, rather than sprouting. Here we investigated...
Rapid vascularization of clinical-size bone grafts is an unsolved challenge in regenerative medicine. Vascular endothelial growth factor-A (VEGF) the master regulator angiogenesis. Its over-expression by genetically modified human osteoprogenitors has been previously evaluated to drive osteogenic grafts, but observed cause paradoxical loss through excessive osteoclast recruitment. However, during development angiogenesis and osteogenesis are physiologically coupled VEGF expression. Here we...
Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes. A poorly understood aspect is how VEGF dose impacts the coordination between these two processes. Taking advantage of a unique highly tunable platform, here we dissected effects over 1,000-fold range context tissue-engineered osteogenic grafts. We found that osteo-angiogenic coupling exquisitely dependent on...
Abstract Background Nasal polyposis frequently occurs within the clinical picture of aspirin‐exacerbated respiratory disease ( AERD ). A derailed arachidonic acid metabolism is regarded to be part pathophysiology , and aspirin desensitization only causal therapeutic option, so far. The optimal maintenance dose prevent nasal polyp recurrence on one hand minimize aspirin‐related side‐effects, other hand, still a matter debate. aim this trial was investigate efficacy safety low‐dose protocol....
Abstract Introduction A range of behavioral testing paradigms have been developed for the research central and peripheral nerve injuries with help small animal models. Following any repair strategy, improved functional outcome may be most important evidence axon regeneration. novel automated gait analysis system, CatWalk ™ , can measure dynamic as well static patterns animals. Of interest in detecting recovery are particular parameters, coordination measures, intensity animals paw prints....
Abstract Stromal Vascular Fraction (SVF) cells freshly isolated from adipose tissue include osteogenic- and vascular-progenitors, yet their relevance in bone fracture healing is currently unknown. Here, we investigated whether human SVF directly contribute to the repair of experimental fractures nude rats, explored feasibility/safety clinical use for augmentation upper arm elderly individuals. Human were loaded onto ceramic granules within fibrin gel implanted critical rat femoral after...
Compared to the general population, transpersons are exposed higher levels of discrimination and violence. The stigmatization can lead physical psychological problems. In particular, transindividuals exhibit a prevalence depression compared cispopulation. gender minority stress model (GMSM) provides comprehensive theoretical basis interpret these biopsychosocial interactions. Using GMSM, this study aimed identify associations between experience mental health transitioned using correlational...
Autologous fat grafting is a popular technique in plastic surgery. A mechanical processing method used to facilitate injection. No study has investigated whether this process affects cell quality and preservation of biological functionality. This analyzed the influence quick through two interconnected small-diameter syringes ("shuffling") on both structure viability tissue, viability, clonogenicity, differentiation freshly isolated stromal vascular fraction.Lipoaspiration was performed six...