René D. Largo

ORCID: 0000-0003-0114-3313
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About
Contact & Profiles
Research Areas
  • Reconstructive Surgery and Microvascular Techniques
  • Reconstructive Facial Surgery Techniques
  • Breast Implant and Reconstruction
  • Mesenchymal stem cell research
  • Bone fractures and treatments
  • Surgical site infection prevention
  • Trauma Management and Diagnosis
  • Wound Healing and Treatments
  • Dental Implant Techniques and Outcomes
  • Head and Neck Cancer Studies
  • Electrospun Nanofibers in Biomedical Applications
  • Orthopedic Surgery and Rehabilitation
  • Periodontal Regeneration and Treatments
  • Nerve Injury and Rehabilitation
  • Sarcoma Diagnosis and Treatment
  • Facial Trauma and Fracture Management
  • Cancer Diagnosis and Treatment
  • Body Contouring and Surgery
  • Breast Cancer Treatment Studies
  • Facial Nerve Paralysis Treatment and Research
  • Anatomy and Medical Technology
  • Tissue Engineering and Regenerative Medicine
  • Surgical Simulation and Training
  • Organ and Tissue Transplantation Research
  • Head and Neck Surgical Oncology

The University of Texas MD Anderson Cancer Center
2016-2025

Temple University
2024

Harvard University
2024

American Academy of Otolaryngology — Head and Neck Surgery
2024

Creative Commons
2017-2023

Memorial Healthcare System
2023

Center For Reconstructive Urethral Surgery
2023

Baxter (United States)
2022

Houston Methodist
2021

Methodist Hospital
2021

Importance Premastectomy radiotherapy (PreMRT) is a new treatment sequence to avoid the adverse effects of on final breast reconstruction while achieving benefits immediate (IMBR). Objective To evaluate outcomes among patients who received PreMRT and regional nodal irradiation (RNI) followed by mastectomy IMBR. Design, Setting, Participants This was phase 2 single-center randomized clinical trial conducted between August 3, 2018, 2, 2022, evaluating feasibility safety RNI (including internal...

10.1001/jamanetworkopen.2024.5217 article EN cc-by-nc-nd JAMA Network Open 2024-04-05

Autologous fat grafting is a popular technique in plastic surgery. A mechanical processing method used to facilitate injection. No study has investigated whether this process affects cell quality and preservation of biological functionality. This analyzed the influence quick through two interconnected small-diameter syringes ("shuffling") on both structure viability tissue, viability, clonogenicity, differentiation freshly isolated stromal vascular fraction.Lipoaspiration was performed six...

10.1097/prs.0000000000001288 article EN Plastic & Reconstructive Surgery 2015-05-28

Background: Robotic surgery is emerging as a viable tool in reconstructive surgery. Harvesting of the deep inferior epigastric perforator flap typically performed through an anterior approach, which involves long fascial incision. A robotic approach allows pedicle to be harvested from posterior surface. This reduces length incision and should decrease abdominal morbidity associated with large dissections. Methods: case series study 21 patients who underwent or during 12-month period for...

10.1097/prs.0000000000008988 article EN Plastic & Reconstructive Surgery 2022-03-07

After reading this article, the participant should be able to: 1. Have a basic understanding of virtual planning, rapid prototype modeling, three-dimensional printing, and computer-assisted design manufacture. 2. Understand principles combining planning vascular mapping. 3. flap choice in preoperative free osteocutaneous flaps mandible midface reconstruction. 4. Discuss advantages disadvantages manufacture reconstruction advanced oncologic defects.Virtual modeling are increasingly used head...

10.1097/prs.0000000000004070 article EN Plastic & Reconstructive Surgery 2017-10-24

Background: Discovering alternatives to workhorse flaps that have more consistent anatomy and lower donor-site morbidity has become a focus of reconstructive surgery research. This study provides simplified approach profunda artery perforator flap design harvest based on reliable anatomical landmarks. Methods: A retrospective review was conducted 70 patients who underwent 83 reconstructions for postoncologic defects from 2016 2018. The authors recorded analyzed the sizes clinical...

10.1097/prs.0000000000007262 article EN Plastic & Reconstructive Surgery 2020-08-26

Opinion regarding the optimal plane for prosthetic device placement in breast reconstruction patients has evolved. The purpose of this study was to assess differences complication rates and patient satisfaction between who underwent prepectoral subpectoral implant-based (IBR).The authors conducted a retrospective cohort two-stage IBR at their institution from 2018 2019. Surgical patient-reported outcomes were compared received versus tissue expander.A total 694 reconstructions 481 identified...

10.1097/prs.0000000000010380 article EN Plastic & Reconstructive Surgery 2023-03-06

Background: Previous studies have explored the ability of artificial intelligence (AI) tools based on large language models, such as Chat Generative Pre-Trained Transformer (ChatGPT), to answer patient questions about breast reconstruction. In this study, we assessed quality generated by ChatGPT for reconstruction patients ask their providers. Methods: was prompted generate appearance-related representative what might during consultations. As a benchmark, comparison group from credible...

10.1097/gox.0000000000006625 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2025-03-01

Background: Posterior mandibulectomy defects can be reconstructed using either soft tissue or vascularized bone. The authors hypothesize that advances in computer-aided design and manufacturing (CAD-CAM) have resulted osteocutaneous free flaps now proving superior to soft-tissue flaps. Methods: conducted a retrospective review of all flap reconstructions posterior where the condyle was resected from 2005 2016. Results: Overall, 291 patients (mean age, 56.9 years; mean body mass index, 26.2...

10.1097/prs.0000000000005954 article EN Plastic & Reconstructive Surgery 2019-08-28

The use of virtual surgical planning and computer-assisted design manufacturing (CAD/CAM) has become widespread for mandible reconstruction with the free fibula flap. However, cost utility this technology remains unknown. authors used a decision tree model to evaluate utility, from perspective hospital or insurer, using CAD/CAM relative conventional (non-CAD/CAM) technique Health state probabilities were obtained published meta-analysis. Costs estimated 2018 Centers Medicare Medicaid...

10.1055/s-0042-1755260 article EN Journal of Reconstructive Microsurgery 2022-08-21

The gold standard treatment of large segmental bone defects is autologous transfer, which suffers from low availability and additional morbidity. Tissue engineered able to engraft orthotopically a suitable animal model for pre-clinical testing are direly needed. This study aimed evaluate engraftment tissue-engineered with different prevascularization strategies in novel defect the rabbit humerus. Decellularized matrix (Tutobone) seeded marrow mesenchymal stromal cells was used directly or...

10.3390/ijms160612616 article EN International Journal of Molecular Sciences 2015-06-04

Background/Aim: Hard palate melanoma is an extremely rare and aggressive tumor arising from the mucosal epithelium of oral cavity. The aim this study was to analyze epidemiology, loco-regional treatment patterns survival outcomes disease. Materials Methods: National Cancer Institute9s Surveillance Epidemiology End Results (SEER) database searched for all cases hard diagnosed between 1973 2012. Kaplan–Meier method used calculate overall rate, log-rank test compare survivals different...

10.21873/anticanres.12921 article EN Anticancer Research 2018-10-01

Background: Smaller anastomotic coupling devices may increase the risk of complications in free flap reconstructions; however, relationship between coupler size and venous thrombosis rates has not been adequately evaluated. The authors hypothesized that smaller diameter are associated with higher than larger tissue transfer. Methods: reviewed a prospectively maintained database for all patients who underwent microsurgical transfer at their institution from 2001 to 2013. primary outcome...

10.1097/prs.0000000000003865 article EN Plastic & Reconstructive Surgery 2017-08-17

Background: Extensive flap salvage attempts are routinely performed in patients with late-onset vascular crisis despite low survival rates. A knowledge gap exists management of compromised free flaps who present perfusion-related complications after hospital discharge. Methods: retrospective review 7443 used 7128 cancer at a single institution from January 2001 to March 2015 was performed. Results: Of reconstructions, 856 (12 percent) were taken back the operating room. Also, 261 (4 suffered...

10.1097/prs.0000000000003917 article EN Plastic & Reconstructive Surgery 2017-12-28

Background: Reducing complications while controlling costs is a central tenet of value-based health care. Bilateral microvascular breast reconstruction long operation with relatively high complication rate. Using two-surgeon team has been shown to improve safety in bilateral reconstruction; however, its impact on cost and efficiency not robustly studied. The authors hypothesized that cosurgeon for safe, effective, associated reduced costs. Methods: retrospectively reviewed all patients who...

10.1097/prs.0000000000008715 article EN Plastic & Reconstructive Surgery 2022-01-25

Although abdominally-based free flaps have long been the gold standard, profunda artery perforator (PAP) flap has emerged as an important alternative option for autologous breast reconstruction. The aim of this study was to directly compare donor site morbidity using PAP versus deep inferior epigastric (DIEP) flap.We performed a retrospective review patients undergoing reconstruction DIEP and/or from January 2017 December 2020. In total, 30 were matched with 60 patients. Outcomes included...

10.1097/gox.0000000000004215 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2022-03-01

Graphical Abstract Scheme of the experimental design. 1, CTA derived from donor Brown Norway rats was de-epithelialized to create DeCTA. 2, RECs were isolated syngeneic recipient Lewis rats. 3, DeCTA pre-epithelialized ReCTA. 4, In heterotopic implantation model, ReCTA subcutaneously implanted into groin area, and an adipose tissue flap pedicled by superficial epigastric blood vessels used for neovascularization. 5, orthotopic neck reconstruct a 4-ring tracheal defect.

10.3389/fbioe.2023.1196521 article EN cc-by Frontiers in Bioengineering and Biotechnology 2023-05-05

Summary: The lateral forearm flap—a thin, fasciocutaneous flap harvested over the epicondyle based on terminal anterior branch of posterior radial collateral artery—is an attractive alternative to flap. authors hypothesized that it is safe and effective for head neck reconstruction. They conducted a retrospective review all reconstructions performed between 2016 2018. Patient demographics, defect characteristics, adjuvant therapies, postoperative complications were recorded. Swallowing diet...

10.1097/prs.0000000000007163 article EN Plastic & Reconstructive Surgery 2020-06-25
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