A5041542657- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Cancer survivorship and care
- BRCA gene mutations in cancer
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Acute Lymphoblastic Leukemia research
- HER2/EGFR in Cancer Research
- Hematopoietic Stem Cell Transplantation
The University of Texas MD Anderson Cancer Center
2016-2025
Sidney Kimmel Comprehensive Cancer Center
2015-2024
Johns Hopkins University
2015-2024
Shionogi (Japan)
2024
Johns Hopkins Medicine
2014-2024
California University of Pennsylvania
2023-2024
Government of the United States of America
2024
Edward Via College of Osteopathic Medicine
2024
Columbia University
2019-2024
Cornell University
2024
Cancer incidence and deaths in the United States were projected for most common cancer types years 2020 2030 based on changing demographics average annual percentage changes death rates. Breast, prostate, lung cancers will remain top diagnoses throughout this time, but thyroid replace colorectal as fourth leading diagnosis by 2030, melanoma uterine become fifth sixth cancers, respectively. Lung is to killer time period. However, pancreas liver are surpass breast, second third causes of...
By 2030, the United States' population will increase to approximately 365 million, including 72 million older adults (age > or = 65 years) and 157 minority individuals. Although cancer incidence varies by age race, impact of demographic changes on has not been fully characterized. We sought estimate number patients diagnosed in States through 2030 race.Current demographic-specific rates were calculated using Surveillance Epidemiology End Results database. Population projections from Census...
Purpose Placing clips in nodes with biopsy-confirmed metastasis before initiating neoadjuvant therapy allows for evaluation of response breast cancer. Our goal was to determine if pathologic changes clipped reflect the status nodal basin and targeted axillary dissection (TAD), which includes sentinel lymph node (SLND) selective localization removal nodes, improves false-negative rate (FNR) compared SLND alone. Methods A prospective study patients metastases a clip placed sampled performed....
Concerns exist regarding breast cancer patients' access to reconstruction, which provides important psychosocial benefits.Using the MarketScan database, a claims-based data set of US patients with employment-based insurance, we identified 20,560 women undergoing mastectomy for from 1998 2007. We evaluated time trends using Cochran-Armitage test and correlated reconstruction use plastic-surgery workforce density other treatments multivariable regression.Median age our sample was 51 years....
The purpose of this study was to determine the association insurance status with disease stage at presentation, treatment, and survival among top 10 most deadly cancers using SEER database.A total 473,722 patients age 18 64 years who were diagnosed one in database from 2007 2010 analyzed. A Cox proportional hazards model used for multivariable analyses assess effect patient tumor characteristics on cause-specific death.Overall, non-Medicaid less likely present distant (16.9%) than those...
The most appropriate dose fractionation for whole-breast irradiation (WBI) remains uncertain.To assess acute and 6-month toxic effects quality of life (QOL) with conventionally fractionated WBI (CF-WBI) vs hypofractionated (HF-WBI).Unblinded randomized trial CF-WBI (n = 149; 50.00 Gy/25 fractions + boost [10.00-14.00 Gy/5-7 fractions]) HF-WBI 138; 42.56 Gy/16 [10.00-12.50 Gy/4-5 following breast-conserving surgery administered in community-based academic cancer centers to 287 women 40 years...
The incidence of early-stage non-small cell lung cancer (NSCLC) among the elderly is expected to rise dramatically owing demographic trends and increased computed tomographic screening. However, our knowledge, no modern trials have compared most common treatments for NSCLC.To determine clinical characteristics survival outcomes associated with 3 commonly used definitive therapies NSCLC in elderly.The Surveillance, Epidemiology, End Results database linked Medicare was baseline 9093 patients...
The use of trastuzumab in the adjuvant setting improves outcomes but is associated with cardiotoxicity manifested as congestive heart failure (CHF). rates and risk factors trastuzumab-related CHF among older patients are unknown.Breast cancer at least 66 years old full Medicare coverage, diagnosed stage I-III breast between 2005 2009, treated chemotherapy were identified SEER-Medicare Texas Cancer Registry-Medicare databases. evaluated. Chemotherapy, use, comorbidities, using International...
Although many plastic surgeons perform autologous fat grafting (lipofilling) for breast reconstruction after oncologic surgery, it has not been established whether postoncologic lipofilling increases the risk of cancer recurrence. The authors assessed locoregional and systemic recurrence in patients who underwent reconstruction.The identified all segmental or total mastectomy (719 breasts) (i.e., cases) reduction benign disease (305 cancer-free followed by with as an adjunct primary...
Seminal investigation 2 decades ago alerted the oncology community to age disparities in participation cooperative group trials; less is known about whether these persist industry-funded research.To characterize among trial enrollees on randomized clinical trials (RCTs) of common cancers and identify factors associated with wider imbalances.Phase 3 RCTs were identified through ClinicalTrials.gov.Multiarm assessing a therapeutic intervention for patients breast, prostate, colorectal, or lung...
<h3>Importance</h3> A pathologic complete response (pCR; no invasive or in situ cancer) occurs 40% to 50% of patients with<i>HER2</i>-positive (<i>HER2</i>+) and triple-negative (TN) breast cancer. The need for surgery if percutaneous biopsy the after neoadjuvant chemotherapy (NCT) indicates pCR (hereinafter referred as pCR) has been questioned, appropriate management axilla such is unknown. <h3>Objective</h3> To identify among exceptional responders NCT with a low risk axillary metastases...
1007 Background: Prospective and retrospective studies of patients (pts) with oligometastatic (OM) disease have supported that metastases (mets) directed treatment (MDT) SBRT or SR in addition to standard care systemic therapy (SOC ST) can improve progression-free (PFS) overall survival (OS) compared SOC ST alone. However, randomized evidence breast cancer (OMBC) are lacking. NRG-BR002, a Phase IIR/III trial, sought determine the efficacy + MDT (SBRT SR) as first line OMBC. Methods: OMBC pts...
PURPOSE: Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in many different tumor types. VEGF levels may affect growth, metastatic potential, and response to radiotherapy. This study assesses the prognostic value of protein a cohort patients with oral oropharyngeal squamous cell carcinomas. The relationships between clinical outcome covariables tumor-node-metastasis stage, disease stage (I IV), grade, margin status, race, sex, age were also determined. PATIENTS AND METHODS:...
Abstract BACKGROUND. The purpose of this study was to determine whether racial disparities in cancer therapy had diminished since the time they were initially documented early 1990s. METHODS. authors identified a cohort patients SEER‐Medicare linked database who ages 66 85 years and primary diagnosis colorectal, breast, lung, or prostate during 1992 through 2002. 7 stage‐specific processes by using Medicare claims. Candidate covariates multivariate logistic regression included year,...
Cerebrovascular disease is common in head and neck cancer patients, but it unknown whether radiotherapy increases the cerebrovascular risk this population.We identified 6,862 patients (age > 65 years) from Surveillance, Epidemiology, End Results (SEER) -Medicare cohort diagnosed with nonmetastatic between 1992 2002. Using proportional hazards regression, we compared of events (stroke, carotid revascularization, or stroke death) after treatment alone, surgery plus radiotherapy, alone. To...
OverviewChronic myelogenous leukemia (CML) accounts for 15% of adult leukemias.Although the median age disease onset is 67 years, CML occurs in all groups (Surveillance, Epidemiology, and End Results [SEER] statistics).In 2009, an estimated 5050 cases will be diagnosed 470 patients die from United States. 1 a hematopoietic stem cell disease, which characterized by reciprocal translocation between chromosomes 9 22, resulting formation Philadelphia chromosome (Ph chromosome).This t(9;22)...
A MEANS OF delivering radiation using an implanted radioactive source and has been used to treat various malignancies.Recently, breast brachytherapy emerged as alternative whole-breast irradiation (WBI), the standard treatment after lumpectomy. 1,2Compared with WBI, irradiates less tissue requires a much shorter course of treatment.As many 10% older women cancer are now treated brachytherapy, 3-5 at least 50 000 have date in United States. 6Controversy persists, however, regarding...