A5044276002- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Endometrial and Cervical Cancer Treatments
- Advanced MRI Techniques and Applications
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Digital Radiography and Breast Imaging
- Advances in Oncology and Radiotherapy
- AI in cancer detection
- Brain Metastases and Treatment
- Lanthanide and Transition Metal Complexes
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Ultrasound and Hyperthermia Applications
- Colorectal Cancer Screening and Detection
- Advanced NMR Techniques and Applications
- Colorectal Cancer Surgical Treatments
Emory University
2024-2025
University of Chicago
2014-2023
University of Chicago Medical Center
1998-2019
The Ohio State University
2016-2018
Taiho Pharmaceutical (Japan)
2018
AstraZeneca (Poland)
2018
Varian Medical Systems (Germany)
2018
Merck (Germany)
2018
Bristol-Myers Squibb (Germany)
2018
Ono Pharmaceutical (United Kingdom)
2018
Purpose Stereotactic body radiotherapy (SBRT) may stimulate innate and adaptive immunity to augment immunotherapy response. Multisite SBRT is an emerging paradigm for treating metastatic disease. Anti-PD-1–treatment outcomes be improved with lower disease burden. In this context, we conducted a phase I study evaluate the safety of pembrolizumab multisite in patients solid tumors. Patients Methods progressing on standard treatment received two four metastases. Not all metastases were...
1007 Background: Prospective and retrospective studies of patients (pts) with oligometastatic (OM) disease have supported that metastases (mets) directed treatment (MDT) SBRT or SR in addition to standard care systemic therapy (SOC ST) can improve progression-free (PFS) overall survival (OS) compared SOC ST alone. However, randomized evidence breast cancer (OMBC) are lacking. NRG-BR002, a Phase IIR/III trial, sought determine the efficacy + MDT (SBRT SR) as first line OMBC. Methods: OMBC pts...
<h3>Importance</h3> Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and increasingly used. Little evidence supports its safe use treat patients with multiple metastases. <h3>Objective</h3> To establish safety of SBRT dose schedules in 3 4 metastases or 2 close proximity each other. <h3>Design, Setting, Participants</h3> This phase 1 trial opened on August 4, 2014, closed accrual March 20, 2018. Metastases 7 anatomic locations were included:...
Given the increased need for consistent quantitative image analysis, variations in radiomics feature calculations due to differences software were investigated. Two in-house packages and two freely available packages, MaZda IBEX, utilized. Forty 256 × 256-pixel regions of interest (ROIs) from 40 digital mammograms studied along with 39 manually delineated ROIs head neck (HN) computed tomography (CT) scans patients. Each package was used calculate first-order histogram second-order gray-level...
Surface Guided Radiation Therapy (SGRT) is being increasingly implemented into clinical practice across a number of techniques and irradiation-sites. This technology, which provided by different vendors, can be used with most simulation- delivery-systems. However, limited guidelines the complexity settings have led to diverse patterns operation. With aim understand current survey was designed focusing on specifics implementation usage.A 32-question covered: type systems, quality assurance...
The purpose of this study was to quantify the variability breast surface position when aligning whole-breast patients bony landmarks based on MV portal films or skin marks alone. Surface imaging used assess 11 radiotherapy patients, but not for patient positioning. On filmed fractions, AlignRT v5.0 capture patient's after initial positioning (28 "preshifts" surfaces), and treatment couch shifts (41 "postshifts" surfaces). Translations rotations captures were recorded, as well films. For...
Abstract In order to independently supervise the medical use of byproduct material, physicists in United States (US) must legally meet qualifications defined by Nuclear Regulatory Commission (NRC) 35th part tenth title Code Federal Regulations (§ 10 CFR Part 35). The American Board Radiology (ABR) relinquished its NRC‐recognized specialty board (NSB) status at end 2023, which eliminated NSB application pathway for those who earn ABR certification 2024 and beyond. While these changes are not...
In this retrospective study, the authors hypothesized that magnetic resonance imaging (MRI) would alter partial breast irradiation (PBI) eligibility by identifying cancers outside PBI volume compared with mammography alone.Since 2002, MRI was used nonselectively at authors' institution for staging of patients nonmetastatic cancer. Of 450 consecutive invasive cancer, 110 who were eligible identified using criteria outlined National Surgical Adjuvant Breast and Bowel Project B-39/Radiation...
Purpose To determine whether the addition of standardized uptake value (SUV) from PET scans to CT lung texture features could improve a radiomics-based model radiation pneumonitis (RP) diagnosis in patients undergoing radiotherapy. Methods and materials Anonymized data 96 esophageal cancer (18 RP-positive cases Grade ≥ 2) were collected including pre-therapy PET/CT scans, pre-/post-therapy diagnostic RP status. Twenty (first-order, fractal, Laws' filter gray-level co-occurrence matrix)...
Abstract Purpose We calculated setup margins for whole breast radiotherapy during voluntary deep‐inspiration breath‐hold ( vDIBH ) using real‐time surface imaging SI ). Methods and Materials Patients n = 58) with a 27‐to‐31 split between right‐ left‐sided cancers were analyzed. Treatment beams gated Align RT by registering the region‐of‐interest to generated from simulation CT scan. recorded (three‐dimensional) 3D displacements beam‐on‐state every 0.3 s. Means standard deviations of each...
Developing automated methods to identify task-driven quality assurance (QA) procedures is key toward increasing safety, efficacy, and efficiency. We investigate the use of machine learning (ML) for possible visualization, automation, targeting QA, assess its performance using multi-institutional data.To enable analysis QA data given higher dimensional nature, we used nonlinear kernel mapping with support vector description (SVDD) driven approaches. Instead labeled as in typical (SVM)...
Abstract Surface imaging (SI) has been rapidly integrated into radiotherapy clinics across the country without specific guidelines and recommendations on its commissioning use aside from vendor‐provided information. A survey was created under auspices of AAPM TG‐302 to assess current status SI identify if there is need for formal guidance. The designed determine institutional setting responders, availability length use, procedures, clinical applications. This in REDCap, approved as IRB...
TPS1117 Background: This is a randomized Phase II/III trial to evaluate if stereotactic body radiotherapy (SBRT) and/or surgical resection (SR) of all metastatic sites in newly oligo-metastatic breast cancer who have received up 12 months first line systemic therapy without progression will significantly improve median free survival (PFS). If this aim met the continues as phase III SBRT/SR improves 5 year overall survival. Secondary aims include local control site, new distant rate, and...
Purpose: The purpose of this study was 2‐fold. One to develop an automated, streamlined quality assurance (QA) program for use by multiple centers. second evaluate machine performance over time centers using linear accelerator (Linac) log files and electronic portal images. authors sought variations in Linac establish as a reference other Methods: developed analytical software tools QA both imaging device (EPID) measurements. first tool is general analysis which can read visually represent...