A5083473334- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Colorectal Cancer Treatments and Studies
- Radiation Therapy and Dosimetry
- Lung Cancer Research Studies
- Cardiac pacing and defibrillation studies
- Management of metastatic bone disease
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Cardiac electrophysiology and arrhythmias
- Meningioma and schwannoma management
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- Gastric Cancer Management and Outcomes
- Cancer-related cognitive impairment studies
Washington University in St. Louis
2016-2025
Washington University Medical Center
2018-2025
Alvin J. Siteman Cancer Center
2011-2024
Barnes-Jewish Hospital
2016-2024
Jewish Hospital
2016-2024
Mallinckrodt (United States)
2013-2024
University of Washington
2024
American Society for Radiation Oncology
2023
Saint Louis University Hospital
2020
NRG Oncology
2016-2017
Purpose Although intensity-modulated radiation therapy (IMRT) is increasingly used to treat locally advanced non-small-cell lung cancer (NSCLC), IMRT and three-dimensional conformal external beam (3D-CRT) have not been compared prospectively. This study compares 3D-CRT outcomes for NSCLC in a large prospective clinical trial. Patients Methods A secondary analysis was performed compare with NRG Oncology trial RTOG 0617, which patients received concurrent chemotherapy of carboplatin paclitaxel...
PURPOSE Radiation dose to the neuroregenerative zone of hippocampus has been found be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain (WBRT) is hypothesized preserve cognition. METHODS This phase III trial enrolled adult patients brain metastases HA-WBRT plus memantine or WBRT memantine. The primary end point was time function failure, defined as decline reliable change index on at least one tests. Secondary points...
Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and delivery precise ablative radiation stereotactic body therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, radioablation for ventricular tachycardia.We targeted arrhythmogenic scar regions by combining anatomical during tachycardia that was induced means an implantable cardioverter-defibrillator (ICD). SBRT simulation, planning, treatments...
PURPOSE RTOG 0617 compared standard-dose (SD; 60 Gy) versus high-dose (HD; 74 radiation with concurrent chemotherapy and determined the efficacy of cetuximab for stage III non–small-cell lung cancer (NSCLC). METHODS The study used a 2 × factorial design dose as 1 factor other, primary end point overall survival (OS). RESULTS Median follow-up was 5.1 years. There were 3 grade 5 adverse events (AEs) in SD arm 9 HD arm. Treatment-related ≥3 dysphagia esophagitis occurred 3.2% 5.0% patients v...
Purpose/objectivesSBRT is used to treat oligometastatic or unresectable primary abdominal malignancies, although ablative dose delivery limited by proximity of organs-at-risk (OAR). Stereotactic, magnetic resonance (MR)-guided online-adaptive radiotherapy (SMART) may improve SBRT's therapeutic ratio. This prospective Phase I trial assessed feasibility and potential advantages SMART malignancies.Materials/methodsTwenty patients with liver (n = 10) non-liver malignancies underwent SMART....
Case studies have suggested the efficacy of catheter-free, electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia (VT) using stereotactic body radiation therapy, although prospective data are lacking.We conducted a phase I/II trial in adults with treatment-refractory episodes VT or cardiomyopathy related to premature contractions (PVCs). Arrhythmogenic scar regions were targeted by combining anatomic and electric imaging standard therapy workflow followed...
<h3>Importance</h3> Stereotactic body radiation therapy (SBRT) has become a standard treatment for patients with medically inoperable early-stage lung cancer. However, its effectiveness in suitable surgery is unclear. <h3>Objective</h3> To evaluate whether noninvasive SBRT delivered on an outpatient basis can safely eradicate cancer and cure selected operable cancer, obviating the need surgical resection. <h3>Design, Setting, Participants</h3> Single-arm phase 2 NRG Oncology Radiation...
Abstract Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude which VT reduction occurs clinically. Here, we demonstrate hearts from RT that radiation achieve transmural within timeframe reduction. Electrophysiologic assessment irradiated murine reveals a persistent supraphysiologic electrical phenotype,...
8506 Background: First line therapy options for advanced NSCLC without actionable molecular alterations include immunotherapy (IO) -/+ chemotherapy or alone. NRG-LU002 was a randomized phase II/III study assessing the benefits of local consolidative (LCT) when added to systemic as maintenance in management oligometastatic NSCLC. Methods: Eligible patients had metastatic with 3 fewer extracranial sites (excluding primary) exhibiting at least stable disease after 4 cycles 1 st therapy....
Stereotactic body radiation therapy (SBRT) is an effective treatment for oligometastatic or unresectable primary malignancies, although target proximity to organs at risk (OARs) within the ultracentral thorax (UCT) limits safe delivery of ablative dose. magnetic resonance (MR)-guided online adaptive (SMART) may improve therapeutic ratio using reoptimization account daily variation in and OAR anatomy. This study assessed feasibility UCT SMART characterized dosimetric clinical outcomes...
Magnetic resonance image guided radiation therapy (MR-IGRT) has been used at our institution since 2014. We report on more than 2 years of clinical experience in treating patients with the world's first MR-IGRT system.A service was opened for January 2014 an system consisting a split 0.35T magnetic scanner that straddles ring gantry 3 multileaf collimator-equipped 60Co heads. The expanded to include online adaptive (ART) and cine gating after 6 9 months, respectively. Patients selected were...
Purpose We describe the acceptance testing, commissioning, periodic quality assurance, and workflow procedures developed for first clinically implemented magnetic resonance imaging‐guided radiation therapy ( MR ‐ IGRT ) system real‐time tracking beam control. Methods The utilizes cine imaging capabilities at 4 frames per second Testing of was performed using an in‐house motion platform a commercially available phantom. Anatomical is by identifying target (a region interest that either tissue...
Indications for external beam radiation therapy (EBRT) atypical meningiomas (AMs) remain unclear.To analyze features associated with recurrence in AM patients after gross total resection (GTR) and to assess the relative benefit of EBRT a retrospective cohort study.One hundred fifty-one primary AMs GTR (88 female patients; median follow-up, 45.0 months) were examined possible predictors (age, sex, location, volume, bone involvement, brain invasion). The Fisher exact Wilcoxon rank-sum tests...