A5103053116- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Neuroscience and Neural Engineering
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Cardiac pacing and defibrillation studies
- Circular RNAs in diseases
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Histone Deacetylase Inhibitors Research
- Medical Imaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Chromatography in Natural Products
- Cell death mechanisms and regulation
- Plant-based Medicinal Research
- RNA and protein synthesis mechanisms
Qilu Hospital of Shandong University
2007-2023
China Medical University
2013-2023
Liaoning Cancer Hospital & Institute
2019-2022
Jiangxi University of Traditional Chinese Medicine
2021-2022
Shandong University
2008-2022
City Of Hope National Medical Center
2022
George Washington University
2016-2021
Washington University in St. Louis
2016-2021
First Affiliated Hospital of Nanchang University
2021
Nanchang University
2021
Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis cardiovascular diseases exploration strategies in electrotherapy, gene therapy, optogenetics. Pacing tools such contexts are currently limited to tethered embodiments that constrain animal behaviors experimental designs. Here, we introduce highly miniaturized wireless energy-harvesting digital communication electronics thin, pacing platforms weighing 110 mg with...
Abstract Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude which VT reduction occurs clinically. Here, we demonstrate hearts from RT that radiation achieve transmural within timeframe reduction. Electrophysiologic assessment irradiated murine reveals a persistent supraphysiologic electrical phenotype,...
A mouse model reveals how seven atrial fibrillation–related risk genes form a network to control heartbeat.
Translation of novel therapies from bench to bedside is hampered by profound disparities between animal and human genetics physiology. The ability test for efficacy cardiotoxicity in a clinically relevant model system would enable more rapid therapy development. We have developed preclinical platform validation new heart tissue using organotypic slices isolated donor end-stage failing hearts. A major advantage the when compared with iPS-derived cardiomyocytes that native architecture...
Background Quercetin is the most abundant flavonoid in fruit and vegetables believed to attenuate cardiovascular disease. We hypothesized that quercetin inhibits cardiac hypertrophy by blocking AP-1 (c-fos, c-jun) activating PPAR-γ signaling pathways. Methodology/Principal Findings The aim of this study was identify mechanism underlying quercetin-mediated attenuation hypertrophy. therapy reduced blood pressure markedly ratio left ventricular body weight (LVW/BW) (P<0.05, vs. spontaneously...
The purpose of this study was to test the hypothesis that overexpression angiotensin-converting enzyme 2 (ACE2) may favorably affect left ventricular (LV) remodeling and function after myocardial infarction (MI). anterior descending coronary artery ligated produce MI in 100 Wistar-Kyoto rats were randomly divided into Ad-ACE2, Ad-ACE2+A779, Ad-EGFP, model, sham groups. Two weeks later, Ad-ACE2 Ad-EGFP groups received direct intramyocardial injection respectively. Rats Ad-ACE2+A779 group both...
Rationale: The heartbeat is organized by the cardiac conduction system (CCS), a specialized network of cardiomyocytes. Patterning CCS into atrial node versus ventricular (VCS) components with distinct physiology essential for normal heartbeat. Distinct VCS has been recognized more than century, but molecular basis this regional patterning not well understood. Objective: To study genetic and genomic mechanisms underlying distinction investigate rhythm consequences failed patterning. Methods...
Long QT syndrome (LQTS) is an inherited or drug induced condition associated with delayed repolarization and sudden cardiac death. The potassium channel, IKr, the adrenergic-sensitive current, IKs, are two primary contributors to repolarization. This study aimed elucidate role of β-adrenergic (β-AR) stimulation in mediating contributions IKr IKs repolarizing human left ventricle (n = 18). Optical mapping was used measure action potential durations (APDs) presence blocker JNJ-303 E-4031. We...
Notch signaling programs cardiac conduction during development, and in the adult ventricle, injury-induced reactivation initiates global transcriptional epigenetic changes.To determine whether may stably alter atrial ion channel gene expression arrhythmia inducibility.To model an injury response effects of on electrophysiology, we transiently activate within myocardium using a doxycycline-inducible genetic system (inducible intracellular domain [iNICD]). Significant heart rate slowing...
Ubiquitin-specific-processing proteases 35 (USP35) is an under-characterized deubiquitinase and its role in colorectal cancer (CRC) remains unclear. Here, we focus on delineating the impact of USP35 CRC cell proliferation chemo-resistance, as well possible regulatory mechanism. By examining genomic database clinical samples, found that was overexpressed CRC. Further functional studies showed enhanced expression promoted resistance to oxaliplatin (OXA) 5-fluorouracil (5-FU), whereas depletion...
The present study aimed to investigate the effect of microRNA (miR) let-7a on ubiquitin specific protease 32 (USP32) expression and its potential function in MCF-7 breast cancer (BCa) cell line. BCa cells were transfected with hsa-miR mimics or inhibitors, then USP32 was evaluated using quantitative reverse transcription polymerase chain reaction (qRT-PCR) western blot analysis cells. as a target regulated by miR confirmed via Dual-luciferase reporter assay. effects viability determined MTT...
One new 8-aryl flavone, podocarflavone A (1), together with 15 previously reported flavonoids were isolated from the twigs and leaves of Podocarpus macrophyllus. Their structures established on basis extensive spectroscopic analysis by comparison data in literature. Antioxidant capacities substances determined using 1,1-diphenyl-2-picrylhydrazyl, ferrous ions, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical vitro assays, their cytoprotective activities also tested H2O2-induced...
Abstract Purpose In this retrospective study, we evaluated the treatment patterns and survival after positron emission tomography-computed tomography (PET/CT)-guided local consolidation therapy (LCT) for oligometastatic non-small cell lung cancer (NSCLC). Methods We reviewed medical records of Chinese patients with stage IV (≤ 5 metastases) who had undergone PET/CT were eligible systemic at two centers between May 2005 August 2019. Propensity score matching (1:1) was used to reduce selection...