A5100408209- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Photorefractive and Nonlinear Optics
- Atherosclerosis and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Solid State Laser Technologies
- Signaling Pathways in Disease
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiomyopathy and Myosin Studies
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Ion-surface interactions and analysis
- Sirtuins and Resveratrol in Medicine
- GDF15 and Related Biomarkers
- Cardiovascular Disease and Adiposity
- Laser-induced spectroscopy and plasma
- Cardiac electrophysiology and arrhythmias
- Lipid metabolism and disorders
- T-cell and B-cell Immunology
- Laser Material Processing Techniques
- Cardiac Arrhythmias and Treatments
- PI3K/AKT/mTOR signaling in cancer
Shandong University
2012-2023
Shandong Mental Health Center
2022
Tianjin Medical University General Hospital
2022
Tianjin Medical University
2022
First Affiliated Hospital of Zhengzhou University
2018-2021
State Key Laboratory of Crystal Materials
2006-2020
Qilu Hospital of Shandong University
2007-2019
Shanghai East Hospital
2019
University of Miami
2014-2015
Inner Mongolia University
2015
Resveratrol, a naturally occurring polyphenolic compound, has been reported to exert anticancer activity by affecting diverse molecular targets. In this study, we examined the effects and underlying mechanisms of resveratrol on gastric cancer. We found that inhibited proliferation cancer cells in dose-dependent manner. At concentration 25 50 µM, cell viability diminished clonogenic potential cells. Resveratrol treatment arrested G1 phase led senescence instead apoptosis. Regulators cycle...
Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status has been well documented to have physiologic benefits in human health. However, the function of SIRT1 cancer remains controversial. Here, expression role gastric delineated. was present all normal mucosa specimens; however, it only portion matched tumor specimens. In SIRT1-positive tumors, both mRNA protein levels were downregulated as compared with corresponding nonneoplastic tissue. Ectopic inhibited...
This study characterized the role of insulin receptors and resistance on vascular endothelial growth factor (VEGF) expression myocardial vascularization in physiological conditions after ischemia.Cardiac microvascular density was reduced by 30% insulin-resistant Zucker fatty rats versus lean controls. associated with a parallel 40% inhibition insulin-stimulated activation both Akt VEGF myocardium cardiomyocytes. In contrast, Erk1/2 remained unchanged. cultured cardiomyocytes, or insulin-like...
• Family 1 glycosyltransferases comprise the greatest number of found in plants. The widespread occurrence and diversity glycosides throughout plant kingdom underscore importance these glycosyltransferases. Here, we describe identification characterization a late-flowering Arabidopsis (Arabidopsis thaliana) mutant, which putative family glycosyltransferase gene, UGT87A2, was disrupted. role possible mechanism UGT87A2 regulation flowering were analyzed by molecular, genetic cellular...
Background It has been demonstrated that Tongxinluo (TXL), a traditional Chinese medicine compound, improves ischemic heart disease in animal models via vascular endothelial growth factor (VEGF) and nitric oxide synthase (eNOS). The present study aimed to investigate whether TXL protects against pressure overload–induced failure mice explore the possible mechanism of action. Methods Results Transverse aortic constriction (TAC) surgery was performed induce failure. Cardiac function evaluated...
CUL4A, a member of the CULLIN family, functions as scaffold protein for an E3 ubiquitin ligase. It was reported that CUL4A gene showed amplification in some human primary hepatocellular carcinomas (HCC). However, exact role HCC remains unknown. Here, we aimed to investigate expression and function development. Through immunohistochemistry study, increased tissues. Statistical analysis disclosed inverse correlation between tumor differentiation grade, patient survival, but positive with...
Background Growth hormone–releasing hormone agonists ( GHRH ‐As) stimulate cardiac repair following myocardial infarction MI ) in rats through the activation of signaling pathway within heart. We tested hypothesis that administration ‐As prevents ventricular remodeling a swine subacute model. Methods and Results Twelve female Yorkshire (25 to 30 kg) underwent transient occlusion left anterior descending coronary artery ). Two weeks post , were randomized receive injections either μg/kg ‐A MR...
Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently...
Serotonin via serotonin 2B receptors (SR2BR) regulates cardiac embryonic development and adult heart functions. However, the role of SR2BR in failing due to pressure overload is not well understood.Wistar rats aortic banding neonatal cardiomyocyte with mechanical stretch were used as cardiomyopathy models.After two weeks surgery, serum serotonin, mRNA protein expression increased significantly. The selective antagonist, SB215505 (SB), significantly reduced increase weight, decreased wall...
Cardiac fibrosis is a key factor to determine the prognosis in patient with myocardial infarction (MI). The aim of this study investigate whether transcriptional paired-related homeobox 2 (Prrx2) regulates Wnt5a gene expression and role following MI. MI surgery was performed by ligation left anterior descending coronary artery. remodelling assessed measuring interstitial Masson staining. Cell differentiation examined analysis alpha-smooth muscle actin (α-SMA). Both Prrx2 expressions were...
Interleukin (IL)-35 is a newly identified immune negative molecule which secreted by CD4+Foxp3+ T regulatory cells (Tregs) and contributes to their suppressive capacity. Early data have shown that IL-35 inhibits development of several autoimmune diseases. However, the role in atherosclerosis, lipid-driven chronic inflammatory disease arterial wall, remains be investigated. Here, we found was involved atherosclerosis apolipoprotein E-deficient (ApoE−/−) mice. ApoE−/− mice with established...
The incidence of cardiac dysfunction after myocardial infarction (MI) continues to increase despite advances in treatment. Excessive fibrosis plays a vital role the development adverse remodeling and deterioration function. Understanding molecular cellular mechanism process developing effective therapeutics are great importance. Salvia miltiorrhiza Carthamus tinctorius extract (SCE) is indicated for angina pectoris other ischemic cardiovascular diseases China. SCE has been shown inhibit...
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by anti-platelet autoantibody-mediated platelet destruction. Antigen-presenting cell (APC) dysfunction considered to play crucial roles in ITP. However, how APC affects autoreactive B cells ITP still unknown. Using a mouse model of immune thrombocytopenia, we demonstrated increase levels TLR7 splenic mononuclear (SMCs). both agonist and silencing lentivirus, found stimulation decreased counts increased platelet-associated...
Decreased heart rate variability (HRV) is a major risk factor for sudden death and cardiovascular disease. We previously demonstrated that parasympathetic dysfunction in the of Akita type 1 diabetic mouse was due to decrease level sterol response element–binding protein (SREBP-1). Here we demonstrate hyperactivity glycogen synthase kinase-3β (GSK3β) atrium results decreased SREBP-1, attenuation modulation rate, measured as high-frequency (HF) fraction HRV presence propranolol, expression...
We investigated the pathogenesis of MYH7-V878A and CACNA1C-A1594V mutations in a Chinese family with hypertrophic cardiomyopathy.Clinical, electrocardiographic (ECG), echocardiographic, cardiac magnetic resonance (CMR) examinations members were followed by exon boarding intron analyses 96 genes proband using second-generation sequencing. confirmed bidirectional Sanger sequencing 300 healthy controls.We detected this family. The both showed inverted T-waves ST-segment depression ECG...
The loss of enteric neurons has been shown to be a major cause slow transit constipation (STC). Gut microbiota and muscularis macrophages (MMs) are associated with the nervous system (ENS) development gastrointestinal (GI) motility. This study aimed investigate whether Dioscin (DIO) increased GI motility inhibited neuron by modulating gut profile, improving inflammation in ENS microenvironment.The STC model was established loperamide. alteration analyzed 16S rDNA sequencing. longitudinal...
Background In the clinic, variations in circadian rhythm are evident patients with cardiovascular disease, and risk of events increases when rhythms disrupted. this study, we focused on role gene period2 (per2) mobilization function endothelial progenitor cells (EPCs) vitro vivo after myocardial infarction (MI) mice. Methods Results MI was produced by surgical ligation left anterior descending coronary artery mice without per2 deficiency. Trans-thoracic echocardiography used to evaluate...
Apoptosis and fatty acid-binding protein-4 (FABP4) induced-endoplasmic reticulum (ER) stress in macrophage is an important pathological process several vascular occlusive diseases, including atherosclerosis, both of which are accelerated by lipids or inflammatory cytokines.To determine whether interleukin 17A (IL-17A) accelerates atherosclerosis through activating FABP4-mediated ER macrophage.We show here that IL-17A induced murine human-derived macrophages vitro, the atherosclerotic lesions...