Joseph R. Simpson

ORCID: 0000-0001-6826-908X
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About
Contact & Profiles
Research Areas
  • Glioma Diagnosis and Treatment
  • Brain Metastases and Treatment
  • Head and Neck Cancer Studies
  • Advanced Radiotherapy Techniques
  • Meningioma and schwannoma management
  • Ear and Head Tumors
  • Lung Cancer Treatments and Mutations
  • Lung Cancer Diagnosis and Treatment
  • Salivary Gland Tumors Diagnosis and Treatment
  • Head and Neck Surgical Oncology
  • Pituitary Gland Disorders and Treatments
  • Cancer Diagnosis and Treatment
  • Medical Imaging Techniques and Applications
  • Psychopathy, Forensic Psychiatry, Sexual Offending
  • Lung Cancer Research Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Neurofibromatosis and Schwannoma Cases
  • Traumatic Brain Injury Research
  • Healthcare Decision-Making and Restraints
  • Neural and Behavioral Psychology Studies
  • Oral and Maxillofacial Pathology
  • Vascular Malformations Diagnosis and Treatment
  • Tracheal and airway disorders
  • Suicide and Self-Harm Studies
  • Breast Cancer Treatment Studies

Banner Health
2025

Virginia Tech
2022-2024

North Shore Diabetes and Endocrine Associates
2024

Rocky Mountain MS Center
2023

University of Colorado Denver
2023

Denver Health Medical Center
2023

University of Southern California
2007-2023

University of Nevada, Reno
2023

The Medical Center of Aurora
2023

Mental Illness Research, Education and Clinical Centers
2023

This report details the patterns of tumor recurrence in two prospective randomized studies involving 551 patients with histologically proven unresectable or medically inoperable non-oat cell carcinoma lung treated definitive radiotherapy. Patients were according to protocols, depending on stage tumor: (1) T1, 2, 3-NO, 1, 2 tumors four different regimens: 4000 cGy split course (2000 five fractions, per 1 week, weeks rest and additional 2000 week) 4000, 5000, 6000 continuous courses, fractions...

10.1002/1097-0142(19870601)59:11<1874::aid-cncr2820591106>3.0.co;2-z article EN Cancer 1987-06-01

Regional cerebral blood flow (BF) was examined in the human medial prefrontal cortex (MPFC) with positron emission tomography during anticipatory anxiety. Transient anxiety induced normal subjects by having them anticipate a painful shock to fingers of one hand. BF decreased anxiety, relative an eyes-closed resting condition, two regions MPFC (Brodmann Areas 10/32 and 24/25). decreases these areas were inversely correlated self rating, such that least anxious exhibited largest reductions,...

10.1073/pnas.98.2.688 article EN Proceedings of the National Academy of Sciences 2001-01-16

Abstract Objective To determine the impact of delayed regional metastases, distant and second primary tumors on therapeutic outcomes in squamous cell carcinomas larynx hypopharynx. Study Design Chart review statistical analysis. Methods A retrospective tumor registry analysis was made patients with hypopharynx who were treated curative intent Department Otolaryngology—Head Neck Surgery Radiation Oncology Center Washington University School Medicine (St. Louis, MO) between January 1971...

10.1097/00005537-200106000-00028 article EN The Laryngoscope 2001-06-01

Regional cerebral blood flow (BF) was examined in regions of the medial prefrontal cortex (MPFC) with positron-emission tomography while subjects performed two cognitive tasks, reading nouns aloud and generating appropriate verbs for same nouns. The control task passive viewing words. BF reduced MPFC during word naïve verb generation, relative to a state which passively viewed Practicing generation produced improved performance, as measured by response time, strongly correlated further...

10.1073/pnas.98.2.683 article EN Proceedings of the National Academy of Sciences 2001-01-16

Positron emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during a graded auditory-verbal memory task. Subjects required to remember and then immediately, freely, recall series auditorily presented word lists varying from two 13 words length. Significant correlations between rCBF load (word list length) identified using statistical parametric mapping. Increasing correlated with increasing the cerebellar vermis hemispheres, thalamus...

10.1093/brain/117.6.1271 article EN Brain 1994-01-01

10.1016/0360-3016(87)90068-x article EN International Journal of Radiation Oncology*Biology*Physics 1987-04-01

Indications for external beam radiation therapy (EBRT) atypical meningiomas (AMs) remain unclear.To analyze features associated with recurrence in AM patients after gross total resection (GTR) and to assess the relative benefit of EBRT a retrospective cohort study.One hundred fifty-one primary AMs GTR (88 female patients; median follow-up, 45.0 months) were examined possible predictors (age, sex, location, volume, bone involvement, brain invasion). The Fisher exact Wilcoxon rank-sum tests...

10.1227/neu.0000000000000461 article EN Neurosurgery 2014-06-13

The functional neuroanatomy of visual processing surface features emotionally valenced pictorial stimuli was examined in normal human subjects using magnetic resonance imaging (fMRI). Pictorial were two types: negative and neutral pictures. Task performance slower for the negatively than Significant blood oxygen level dependent (BOLD) increases occurred medial dorsolateral prefrontal cortex, midbrain, substantia innominata, and/or amygdala, posterior cortical areas both stimulus types....

10.1162/089892900564019 article EN Journal of Cognitive Neuroscience 2000-11-01

We evaluated the impact of treatment modality on esthesioneuroblastoma.Between 1976 and 1996, 25 patients with esthesioneuroblastoma were treated at Mallinckrodt Institute Radiology. There 11 male 14 female patients; their ages ranged from 16 to 73 years (median, 57 years). The tumors Kadish stage A in 3, Stage B 13, C 8, modified D 1 (cervical nodal metastasis). Seventeen surgery radiation therapy, six irradiation alone, two only. Eight received neoadjuvant chemotherapy. Median follow-up...

10.1002/hed.1107 article EN Head & Neck 2001-08-08

10.1016/0360-3016(82)90443-6 article EN International Journal of Radiation Oncology*Biology*Physics 1982-11-01

The records of 71 patients with adenoid cystic carcinoma the salivary glands were reviewed to determine dose response relationships for this aggressive tumor. Local control after treatment was determined all and analyzed respect extent surgery radiation. Of 70 who available evaluation local control, 28 (40%) had a recurrence 42 (60%) did not. highest rates found in underwent both radiation therapy surgery. Patients received equal or greater than 6,000 rad (60 Gy) addition significantly...

10.1148/radiology.151.2.6324280 article EN Radiology 1984-05-01

Large cerebral arteriovenous malformations (AVMs) are often not amenable to direct resection or stereotactic radiosurgery (SRS) treatment. An alternative treatment strategy is staged endovascular embolization followed by SRS (Embo/SRS). The object of this study was examine the experience at Washington University in St. Louis with Embo/SRS for large AVMs and review results earlier case series.Twenty-one cases involving patients treated between 1994 2006 were retrospectively evaluated. AVM...

10.3171/2011.1.jns10571 article EN Journal of neurosurgery 2011-02-18
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