A5008096514- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Nerve injury and regeneration
- Particle physics theoretical and experimental studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell death mechanisms and regulation
- Medical Imaging Techniques and Applications
- High-Energy Particle Collisions Research
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Surgical Oncology
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Neurofibromatosis and Schwannoma Cases
- Quantum Chromodynamics and Particle Interactions
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
- Amino Acid Enzymes and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Advanced Radiotherapy Techniques
Neurological Surgery
2013-2025
Washington University in St. Louis
2014-2023
Oxford University Press (United Kingdom)
2020
Mayo Clinic in Florida
2018
WinnMed
2018
Jewish Hospital
2017
Barnes-Jewish Hospital
2017
Mallinckrodt (United States)
1998-2015
Alvin J. Siteman Cancer Center
2007-2014
Cancer Research And Biostatistics
2013-2014
Cilengitide, an inhibitor of alphavbeta3 and alphavbeta5 integrin receptors, demonstrated minimal toxicity durable activity across a wide range doses administered to adults with recurrent glioblastoma multiforme (GBM) in prior phase I study. The current multicenter II study was conducted evaluate the safety cilengitide GBM patients at first recurrence.Eligible were randomly assigned receive either 500 or 2,000 mg twice weekly on continuous basis. Patients assessed every 4 weeks. primary end...
To describe baseline clinical features and outcomes of adults with moyamoya phenomenon treated at a single North American institution.We identified 34 by review angiographic records. Clinical presentation stroke risk factors were obtained chart review. Follow-up was prospectively. A 5-year Kaplan-Meier calculated.The median age 42 (range 20 to 79) years. Twenty-five women. The initial symptom ischemia, hemorrhage, or asymptomatic in 24, 7, 3 patients, respectively. Twenty-two had bilateral...
Although 1p/19q codeletions define "genetically favorable" oligodendrogliomas, eventual tumor progression and patient death remain constant. Genetic testing is often performed at the time of recurrence, though it unclear whether these or other genetic alterations provide useful prognostic information. We characterized 138 189 (73%) available primary recurrent oligodendroglial neoplasms from 80 patients, utilizing paired FISH probes for 1p32/1q42, 19p13/19q13, CEP7/ EGFR, CEP9/p16,...
From a sample of hadronic events produced in ${e}^{+}{e}^{\ensuremath{-}}$ collisions, semileptonic decays heavy particles have been isolated and used to obtain measurement for the bottom-quark lifetime [1.8\ifmmode\pm\else\textpm\fi{}0.6 (stat.)\ifmmode\pm\else\textpm\fi{}0.4(syst.)]\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}12}$ sec.
Abstract The response of dorsal root ganglia (DRG) neurons to NGF deprivation and axotomy was examined in adult guinea pigs. success by means an autoimmune approach monitored the measurement serum antibody titer levels against pig with standard bioassay for activity. That produced confirmed histologic evidence neuronal atrophy apparent cell loss sections superior cervical (SCG) marked decreases (65–80%) SCG neurotransmitter‐synthesizing enzyme activity levels. By using a new source pigs...
Cranial dural arteriovenous fistulae (dAVF) with cortical venous drainage (CVD) (Borden Types 2 and 3) are reported to carry a 15% annual risk of intracranial hemorrhage (ICH) or nonhemorrhagic neurological deficit (NHND). The purpose this study was compare the clinical course Type 3 dAVFs that present ICH NHND those do not.Twenty-eight patients were retrospectively evaluated. CVD classified as asymptomatic (aCVD) if presented incidentally pulsatile tinnitus orbital phenomena. symptomatic...
OBJECTIVE Colloid cysts are rare, histologically benign lesions that may result in obstructive hydrocephalus and death. Understanding the natural history of colloid has been challenging given their low incidence small number cases most reported series. This complicated efforts to establish reliable prognostic factors surgical indications, particularly for asymptomatic patients with incidental lesions. Risk setting remain poorly defined, there no grading scales on which develop standard...
Object The purpose of aneurysm surgery is complete obliteration while sparing associated arteries. Indocyanine green (ICG) videoangiography a new technique that allows for real-time evaluation blood flow in the and vessels. authors performed retrospective study to compare accuracy ICG with intraoperative angiography (IA), determine if can be used without follow-up IA. Methods From June 2007 through September 2009, 155 patients underwent craniotomies clipping aneurysms. Operative summaries,...
Indications for external beam radiation therapy (EBRT) atypical meningiomas (AMs) remain unclear.To analyze features associated with recurrence in AM patients after gross total resection (GTR) and to assess the relative benefit of EBRT a retrospective cohort study.One hundred fifty-one primary AMs GTR (88 female patients; median follow-up, 45.0 months) were examined possible predictors (age, sex, location, volume, bone involvement, brain invasion). The Fisher exact Wilcoxon rank-sum tests...
Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD+). Nevertheless, how the regulation of this cofactor interfaces with signal transduction networks remains poorly understood in glioblastoma. Here, we report phosphoribosyltransferase (NAMPT), rate-limiting step NAD+ synthesis, is highly expressed glioblastoma tumors and patient-derived stem-like (GSCs). High NAMPT expression correlates decreased patient...
Highlights•CDC20-APC drives the invasiveness and self-renewal of glioblastoma stem-like cells•CDC20 is essential for in vivo tumorigenicity cells•CDC20-APC operates through SOX2 to control cell function•CDC20 prognostic overall survival Proneural subtype patientsSummaryGlioblastoma harbors a dynamic subpopulation cells (GSCs) that can propagate tumors resistant standard chemoradiation. Identification cell-intrinsic mechanisms governing this clinically important state may lead discovery...
Object. Ischemic stroke or transient ischemic attack (TIA) may occur after the treatment of intracranial aneurysms with Guglielmi detachable coils (GDCs). The purpose present study is to investigate possible risk factors for thromboembolic events and determine their frequency time course. Methods. records 178 consecutive patients 193 treated saccular were reviewed. A total 159 GDC procedures performed treat 143 in 133 those who good neurological condition, allowing clinical detection...
Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) was performed in 19 patients brain metastases from non-central nervous system (CNS) neoplasms and one patient a primary CNS lymphoma. Various histopathologic types were represented by the metastases. Only 21 of 31 lesions (68%) detected FDG PET as discrete, metabolically active foci (relative to surrounding structures). Six nondetected may have been nondiscernible owing their small size and/or isointensity relative...
The differential cross sections for the elastic scattering of π+, π−, K+, K−, p, and ¯p on protons have been measured in t interval -0.04 to -0.75 GeV2 at five momenta: 50, 70, 100, 140, 175 GeV/c. distributions parametrized by quadratic exponential form dσdt=Aexp(B∣∣t∣∣+C|t|2) energy dependence has described terms a single-pole Regge model. pp K+p diffraction peaks are found shrink with α′∼0.20 ∼0.15 GeV−2, respectively. ¯pp peak is antishrinking while π±p K−p relatively energy-independent....
Twenty-five patients with metastatic thoracic and lumbar spine disease were initially treated by the authors posterolateral debridement decompression, along posterior segmental spinal instrumentation. Ten had marked paresis, nine signs of cord or cauda equina compression without all pain severe enough to prevent sitting/standing/walking. The approach was used in these instead an anterior one because translocation (4), three-column (16), three more vertebral bodies involved (13), at two...
Object The aim of this study was to determine the efficacy venous ultrasonography in screening for deep thrombosis (DVT) after subarachnoid hemorrhage (SAH). A large cohort patients who had suffered SAH evaluated with primary end points ascertaining incidence asymptomatic DVT Doppler and identifying risk factors development subsequent pulmonary embolism. Methods Data from aneurysmal been admitted neurosurgical intensive care unit (ICU) between December 2002 October 2006 were retrospectively...
Large cerebral arteriovenous malformations (AVMs) are often not amenable to direct resection or stereotactic radiosurgery (SRS) treatment. An alternative treatment strategy is staged endovascular embolization followed by SRS (Embo/SRS). The object of this study was examine the experience at Washington University in St. Louis with Embo/SRS for large AVMs and review results earlier case series.Twenty-one cases involving patients treated between 1994 2006 were retrospectively evaluated. AVM...