- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Hip disorders and treatments
- Cervical and Thoracic Myelopathy
- Shoulder Injury and Treatment
- Spinal Hematomas and Complications
- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Nerve Injury and Rehabilitation
- Congenital Diaphragmatic Hernia Studies
- Management of metastatic bone disease
- Craniofacial Disorders and Treatments
- Spinal Dysraphism and Malformations
- Aortic Disease and Treatment Approaches
- Spinal Cord Injury Research
- Health Systems, Economic Evaluations, Quality of Life
- Infectious Diseases and Tuberculosis
- Neurofibromatosis and Schwannoma Cases
Washington University in St. Louis
2015-2024
University of California, San Francisco
2009-2023
Barnes-Jewish Hospital
2005-2021
American University of Beirut Medical Center
2020
Duke University
2020
Rush University Medical Center
2017
Presbyterian St. Luke's Medical Center
2017
Post Graduate Institute of Medical Education and Research
2017
National Institutes of Health
2015
Shriners Hospitals for Children - St. Louis
2002-2013
In Brief Study Design. This study is a retrospective review of 752 patients with adult spinal deformity enrolled in multicenter prospective database 2002 and 2003. Patients positive sagittal balance (N = 352) were further evaluated regarding radiographic parameters health status measures, including the Scoliosis Research Society patient questionnaire, MOS short form-12, Oswestry Disability Index. Objectives. To examine to define within that group might differentially predict clinical impact....
In Brief Study Design. This study is a retrospective review of the initial enrollment data from prospective multicentered adult spinal deformity. Objectives. The purpose this to correlate radiographic measures deformity with patient-based outcome in scoliosis. Summary Background Data. Prior studies scoliosis have attempted appearance and clinical symptoms, but it has proven difficult predict health status based on alone. ability symptoms would be useful for decision-making surgical planning....
Surgical site infections are not uncommon following spinal operations, and they can be associated with serious morbidity, mortality, increased resource utilization. The accurate identification of risk factors is essential to develop strategies prevent these potentially devastating infections. We conducted a case-control study determine independent for surgical infection orthopaedic operations.We performed retrospective patients who had an operation at university-affiliated tertiary-care...
Recent advances in spinal instrumentation have brought about a new emphasis on the three-dimensional deformity of scoliosis and especially restoration normal sagittal plane contours. Normal alignment coronal transverse planes is easily defined; however, not so simple. This retrospective study was undertaken to increase understanding spine plane, with special thoracolumbar junction. Measurements were made from lateral radiographs 102 subjects clinically radiographically spines. Cobb...
A retrospective study.To evaluate the safety of a free hand technique pedicle screw placement in thoracic spine at single institution over 10-year experience.Thoracic fixation techniques are still controversial for deformities because possible complications including neurologic.Three hundred ninety-four consecutive patients who underwent posterior stabilization utilizing 3204 transpedicular screws by 2 surgeons from 1992 to 2002 were analyzed. The mean age was 27 + 10 years (range 5 3-87 0...
Study Design. A radiographic evaluation of 100 adult volunteers over age 40 and without a history significant spinal abnormality was done to determine indices sagittal alignment. Objectives. To the contours spine in population adults older than previously reported literature correlate overall balance other measures segmental Summary Background Data. Previous studies alignment have focused on adolescent young populations before onset degenerative changes that may affect Methods. Radiographic...
In Brief Study Design. To analyze patient outcomes and risk factors associated with proximal junctional kyphosis (PJK) in adults undergoing long posterior spinal fusion. Objectives. determine the incidence of PJK its effect on to identify any developing PJK. Summary Background Data. The affect adult deformity patients is unknown. No study has concentrated Risk for are Methods. Radiographic data 81 consecutive minimum 2-year follow-up (average 5.3 years, range 2–16 years) treated instrumented...
Background: The purpose of the present study was to determine effectiveness selective nerve-root injections in obviating need for an operation patients with lumbar radicular pain who were otherwise considered be operative candidates. Although are used widely, we not aware any prospective, randomized, controlled, double-blind studies demonstrating their efficacy. Methods: Fifty-five referred four spine surgeons because and had radiographic confirmation compression prospectively randomized...
Summary: Between February 1985 and March 1990 44 patients with degenerative spondylolisthesis underwent primary surgery for spinal stenosis (in all cases the decompression preserved facets bilaterally without discectomy) were studied prospectively. Forty-three have been followed ≥2 years are basis of this study. There three treatment groups: group I. no fusion (nine patients); II, transverse process autogenous iliac bone graft instrumentation (11 initial patients, one lost to follow-up a...
Perioperative myocardial infarction is the most common cause of morbidity and mortality in patients who have had noncardiac surgery, but its diagnosis can be difficult. The present study was designed to determine whether measurement serum levels cardiac troponin I, a highly sensitive specific marker for injury, would help establish infarction.
In Brief Study Design. A retrospective analysis, including prospectively collected patient outcomes data. Objective. To determine the rate of complications and in patients ≥60 years age who underwent major spinal deformity surgery requiring a minimum 5-level arthrodesis procedure. Summary Background Data. As population ages, an increasing number older are presenting with disorders that may require reconstructive procedures. Previous studies have reported complication rates as high 80% this...
In Brief Study Design. Retrospective case-control series. Objective. The purpose of this study is to determine whether perioperative complications alter subsequent clinical outcome measures in adult spinal deformity surgery. Summary Background Data. Increasingly, the benefit surgical intervention being evaluated based on patient reported outcomes and standardized health related quality life (HRQOL) measures. As improvement or deterioration HRQOL scores becomes a standard for evaluation...
Study Design. This was a prospective study of 24 adult patients with kyphosis or anterior column spinal defects treated fresh frozen allograft for and posterior instrumentation autogenous grafting. Objectives. The objectives the were to assess effectiveness in maintaining sagittal correction incorporation. Summary Background Data. Twenty-four followed minimum 2 years (range, + 0-5 4 years). Methods. Upright radiographs analyzed before surgery, immediately after at final follow-up examination...
In Brief Study Design. Retrospective radiographic outcomes analysis. Objective. We had 3 hypotheses: 1) a longer fusion; 2) more proximal instrumented vertebra, and 3) circumferential fusion versus posterior-only would increase the likelihood of adjacent segment disease (ASD). Summary Background Data. The literature analyzing risk factors, prevalence, presentation patients with ASD is varied without clear consensus. Methods. A total 188 minimum 5-year follow-up who lumbar/thoracolumbar...
In Brief Study Design. A retrospective matched cohort study. Objective. To comprehensively compare the 2-year postoperative results of posterior correction and fusion with segmental pedicle screw instrumentation versus hybrid (proximal hooks distal screws) constructs in adolescent idiopathic scoliosis (AIS) treated at a single institution. Summary Background Data. Despite reports satisfactory maintenance scoliotic curves by instrumentation, there have been no on comprehensive comparison AIS...
In Brief Study Design. Retrospective study. Objective. To analyze the incidence of and risk factors for pseudarthrosis in long adult spinal instrumentation fusion to S1. Summary Background Data. Few studies on S1 exist. Methods. A clinical radiographic assessment 144 patients with deformity (average age 52.0 years; range 21.1–77.6) who underwent (5–17 vertebrae, average 11.9) sacrum at a single institution between 1985 2002, minimum 2-year follow-up 3.9; 2–14) was performed. Results. Of...
In Brief Study Design. A retrospective study. Objective. To analyze time-dependent change of, prevalence and risk factors for proximal junctional kyphosis (PJK) in adult spinal deformity after long (≥5 vertebrae) segmental posterior instrumented fusion with a minimum 5-year postoperative follow-up. Summary of Background Data. No study has focused on long-term Methods. Clinical radiographic data 161 (140 women/21 men) patients follow-up (average 7.8 years, range 5–19.8 years) treated...
Fixed sagittal imbalance (a syndrome in which the patient is only able to stand with weight-bearing line front of sacrum) has many etiologies. The most commonly reported technique for correction Smith-Petersen osteotomy. Few reports on pedicle subtraction procedures (resection posterior elements, pedicles, and vertebral body through a approach) are available peer-reviewed literature. We aware no report involving substantial number patients coexistent scoliosis who underwent pedicle/vertebral...
Retrospective radiographic review.To analyze how the Lenke classification of adolescent idiopathic scoliosis provides a template specific curve patterns that may be appropriate to perform selective fusion spine.A new triad system has been developed. It consists type, lumbar spine modifier (A, B, C), and sagittal thoracic (-, N, +). A is termed when both thoracolumbar/lumbar curves deviate completely from midline, but only major (largest Cobb measurement) fused, leaving minor unfused mobile....
Clinical radiographic and outcomes investigation.To investigate clinical for lumbosacral fusion (in patients with spinal deformity) using a combination of bilateral sacral iliac screws minimum 5-year follow-up.To our knowledge, long-term results (>5 years follow-up) S1 screw/bilateral screw fixation have never been published or presented.A total 67 (from an initial consecutive cohort 81) undergoing follow-up 5 (range 5-10 + 5, average 6 3) were analyzed outcome course by questionnaire...
In Brief Study Design. Prospective observational cohort study with matched and unmatched comparisons. Level II evidence. Objective. The purpose of this is to compare results adult symptomatic lumbar scoliosis (ASLS) patients treated nonoperatively operatively. This an evidence-based prospective multicenter answer the question whether nonoperative operative treatment improves quality life (QOL) in these at 2-year follow-up. Summary Background Data. Only 1 paper peer-reviewed published data...
In Brief Study Design. Retrospective review of a prospective, multicenter database. Objective. The purpose this study was to assess whether elderly patients undergoing scoliosis surgery had an incidence complications and improvement in outcome measures comparable with younger patients. Summary Background Data. Complications increase age for adults surgery, but impacts the outcomes older is largely unknown. Methods. This retrospective spinal deformity Patients complete Oswestry Disability...