A5030000077- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer-related cognitive impairment studies
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Management of metastatic bone disease
- Effects of Radiation Exposure
- Neurofibromatosis and Schwannoma Cases
- Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Colorectal and Anal Carcinomas
Siemens Healthcare (United States)
2021-2024
Varian Medical Systems (United States)
2012-2023
Varian Medical Systems (United Kingdom)
2021
Eden Medical Center
2018-2020
Sutter Health
2019
Mills Peninsula Health Services
2013-2018
Eli Lilly (Singapore)
2014
University of Wisconsin–Madison
2004-2014
UW Health University Hospital
2005-2014
Target (United States)
2014
To determine the protective effects of memantine on cognitive function in patients receiving whole-brain radiotherapy (WBRT).Adult with brain metastases received WBRT and were randomized to receive placebo or (20 mg/d), within 3 days initiating for 24 weeks. Serial standardized tests performed.Of 554 who accrued, 508 eligible. Grade 4 toxicities study compliance similar 2 arms. There was less decline delayed recall arm at weeks (P = .059), but difference not statistically significant,...
PURPOSE Radiation dose to the neuroregenerative zone of hippocampus has been found be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain (WBRT) is hypothesized preserve cognition. METHODS This phase III trial enrolled adult patients brain metastases HA-WBRT plus memantine or WBRT memantine. The primary end point was time function failure, defined as decline reliable change index on at least one tests. Secondary points...
Purpose To report results of a randomized phase II trial (Radiation Therapy Oncology Group RTOG-0234) examining concurrent chemoradiotherapy and cetuximab in the postoperative treatment patients with squamous cell carcinoma head neck (SCCHN) high-risk pathologic features. Patients Methods Eligibility required stage III to IV SCCHN gross total resection showing positive margins and/or extracapsular nodal extension two or more metastases. were randomly assigned 60 Gy radiation once per week...
Abstract Background FLASH therapy is a treatment technique in which radiation delivered at ultra-high dose rates ( ≥ 40 Gy/s). The first-in-human FAST-01 clinical trial demonstrated the feasibility of proton extremity bone metastases. objectives this investigation are to assess toxicities and pain relief study participants with painful thoracic metastases treated radiotherapy, as well workflow metrics setting. Methods This single-arm being conducted under an FDA investigational device...
Purpose Local failure rates after radiation therapy (RT) for locally advanced non–small-cell lung cancer (NSCLC) remain high. Consequently, RT dose intensification strategies continue to be explored, including hypofractionation, which allows acceleration that could potentially improve outcomes. The maximum-tolerated (MTD) with dose-escalated hypofractionation has not been adequately defined. Patients and Methods Seventy-nine patients NSCLC were enrolled on a prospective single-institution...
Background In preclinical studies, FLASH therapy, in which radiation delivered at ultrahigh dose rates of ≥40 Gy per second, has been shown to cause less injury normal tissues than radiotherapy conventional rates. This paper describes the protocol for first-in-human clinical investigation proton therapy. Objective FAST-01 is a prospective, single-center trial designed assess workflow feasibility, toxicity, and efficacy therapy treatment painful bone metastases extremities. Methods Following...
Long-term outcomes of radiotherapy are important in understanding the risks and benefits therapies for patients with brain metastases.To determine how use postoperative whole-brain (WBRT) or stereotactic radiosurgery (SRS) is associated quality life (QOL), cognitive function, intracranial tumor control long-term survivors 1 to 4 metastases.This secondary analysis a randomized phase 3 clinical trial included 48 institutions US Canada. Adult resected metastases but limited those metastasis...
Clarify the role for postoperative radiation adenoid cystic carcinoma (ACC) of head and neck as it relates to tumor site, T-stage, surgical margin status.Retrospective cohort study at an academic tertiary care hospital.A review 129 patients with biopsy-proven ACC was performed. Previous treatment failures nonoperative candidates were excluded, 75 considered eligible further study. Patients grouped according modality Kaplan-Meier estimates overall survival, locoregional control, distant...
FLASH radiotherapy (FLASH-RT) delivers radiation treatment at an ultra-high dose rate that is several orders of magnitude higher than current clinical practice. In multiple preclinical studies, FLASH-RT has shown consistent normal tissue sparing effects while preserving equivalent antitumour activity in comparison with conventional treatment. This known as the ‘FLASH effect’. Given recent research interest combining hypofractionated immunotherapy to try improve outcomes, there intriguing...