A5012307259- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Radiation Therapy and Dosimetry
- Ovarian cancer diagnosis and treatment
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Urinary and Genital Oncology Studies
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Boron Compounds in Chemistry
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Treatment and Pharmacology
- Calibration and Measurement Techniques
- Hormonal and reproductive studies
- Salivary Gland Tumors Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Cancer Studies
- Radio Frequency Integrated Circuit Design
Varian Medical Systems (United States)
2022-2023
Varian Medical Systems (United Kingdom)
2023
Aberdeen Royal Infirmary
2022
NHS Grampian
2022
Siemens Healthcare (United States)
2022
Seattle Cancer Care Alliance
2017-2021
Roche (Switzerland)
2010-2021
Radiation Oncology Associates
2021
University of Washington
2006-2020
Enzo Life Sciences (Switzerland)
2014-2020
The aim of this study was to examine the hypothesis that alveolar macrophages represent a significant source matrix-degrading proteinases in emphysematous lung. Macrophages from bronchoalveolar lavage fluid 10 patients with emphysema and normal volunteers were maintained vitro for 24 h assessed semiquantitatively mRNA transcript levels matrix metalloproteinases (MMPs) gelatinases A B, macrophage metalloelastase (MME), interstitial collagenase. Release these MMPs into culture medium secretion...
To our knowledge, there have been no clinical trials of ultra-high-dose-rate radiotherapy delivered at more than 40 Gy/sec, known as FLASH therapy, nor first-in-human use proton FLASH.To assess the workflow feasibility and treatment-related toxic effects pain relief treatment sites.In FAST-01 nonrandomized trial, participants treated Cincinnati Children's/UC Health Proton Therapy Center underwent palliative to extremity bone metastases. Patients 18 years older with 1 3 painful metastases...
A review of various techniques for coherently combining microwave power from two or more sources is presented. Emphasis placed on which combine solid-state sources. Basic operating characteristics and limitations the different combiner types are discussed. The performances obtained with most successful described. Future trends in RF identified.
Matrix degradation in emphysema has long been attributed to the action of neutrophil elastase (NE). More recently a role for other proteases, particularly matrix metalloproteinases (MMPs), pathogenesis this disease proposed. To date, however, presence MMPs lungs patients with not demonstrated.Samples bronchoalveolar lavage (BAL) fluid from 10 and control subjects matched sex current smoking status were assessed collagenase, gelatinase, NE activity. Pulmonary function tests computed...
Background In preclinical studies, FLASH therapy, in which radiation delivered at ultrahigh dose rates of ≥40 Gy per second, has been shown to cause less injury normal tissues than radiotherapy conventional rates. This paper describes the protocol for first-in-human clinical investigation proton therapy. Objective FAST-01 is a prospective, single-center trial designed assess workflow feasibility, toxicity, and efficacy therapy treatment painful bone metastases extremities. Methods Following...
Advanced stage/recurrent clear cell ovarian cancers (CCOCs) are characterized by a low response to chemotherapy and poor prognosis. There is growing interest in investigating novel/molecular targeted therapies patients with CCOC histotype-specific trials. However, CCOCs not uniform entity comprise number of molecular subtypes it unlikely that single approach treatment will be appropriate for all patients. The aim this study was analyze the results multiplatform profiling panel identify...
No AccessJournal of Urology1 Oct 1991Prostate Specific Antigen in the Management Patients with Localized Adenocarcinoma Prostate Treated Primary Radiation Therapy K.J. Russell, C. Dunatov, M.D. Hafermann, J.T. Griffeth, L. Polissar, J. Pelton, S.B. Cole, E.W. Taylor, L.W. Wiens, W.J. Koh, M.M. Austin-Seymour, B.R. Griffin, A.H. G.E. Laramore, and T.W. Griffin RussellK.J. Russell , DunatovC. Dunatov HafermannM.D. Hafermann GriffethJ.T. Griffeth PolissarL. Polissar PeltonJ. Pelton ColeS.B....
Between June 1977 and April 1983 the Radiation Therapy Oncology Group (RTOG) sponsored a Phase III randomized trial investigating use of fast neutron radiotherapy for patients with locally advanced (Stages C D1) adenocarcinoma prostate gland. Patients were to receive either conventional photon radiation or used in mixed-beam (neutron/photon) treatment schedule. A total 91 analyzable entered into study, two patient groups balanced respect major prognostic variables. Actuarial curves are...
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Purpose This was an exploratory analysis of a trial intermittent androgen deprivation (IAD) in men with biochemical relapse (BR) to establish first cycle characteristics prognostic for progression castration-resistant prostate cancer (CRPC) and death. Patients Methods Men BR after radical prostatectomy (RP) or radiation (RT) were treated therapy (ADT) comprised leuprolide flutamide. After 9 months on treatment, ADT stopped, monthly prostate-specific antigen (PSA) levels observed during the...
Although neutrophil migration from the systemic circulation involves beta2- (or CD18) integrin family, existence of an alternative, CD18-independent route extravasation to tissues has been demonstrated in animal models. The molecular interactions involved this alternative migratory have not yet characterized. objective study was assess CD18-dependency across human endothelial cells organ known support migration, lung, with a view establishing vitro model facilitate migration. Neutrophil...
Endocrine therapy is used as maintenance in estrogen receptor (ER) positive breast cancers and has been proposed low-grade serous ovarian (LGSOC). Here we examine a rationale for its use high-grade (HGSOC).We accessed the TCGA PANCAN dataset to evaluate expression of ESR1. ESR1 data on all (n=8901) HGSOC (n=527) were followed by investigation ER via immunohistochemistry (IHC) (n=4071). The same was performed an independent cohort matched primary recurrent (n=80). Finally, newly diagnosed ER+...