A5005244252- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Tracheal and airway disorders
- Peptidase Inhibition and Analysis
- Clinical practice guidelines implementation
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Enzyme function and inhibition
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Grief, Bereavement, and Mental Health
- Restraint-Related Deaths
- Enhanced Recovery After Surgery
- Pelvic and Acetabular Injuries
- Cardiac tumors and thrombi
- Coronary Artery Anomalies
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Musculoskeletal Disorders and Rehabilitation
Sanofi (United States)
2020-2024
AVEO Oncology (United States)
2024
St. Vincent's University Hospital
1991-2004
University College Dublin
1991-2002
St. Vincent's Hospital
1988-1998
St Vincent's Hospital
1987-1998
Trinity College Dublin
1998
St. Vincent's Birmingham
1986-1996
Saint Vincent's Catholic Medical Center
1985-1994
St. James's Hospital
1982-1993
Matrix degradation in emphysema has long been attributed to the action of neutrophil elastase (NE). More recently a role for other proteases, particularly matrix metalloproteinases (MMPs), pathogenesis this disease proposed. To date, however, presence MMPs lungs patients with not demonstrated.Samples bronchoalveolar lavage (BAL) fluid from 10 and control subjects matched sex current smoking status were assessed collagenase, gelatinase, NE activity. Pulmonary function tests computed...
Abstract Microglia serve as the innate immune cells of central nervous system (CNS) by providing continuous surveillance CNS microenvironment and initiating defense mechanisms to protect tissue. Upon injury, microglia transition into an activated state altering their transcriptional profile, transforming morphology, producing pro-inflammatory cytokines. These initially a beneficial role, but continued activation drives neuroinflammation neurodegeneration. Multiple sclerosis (MS) is chronic,...
The purpose of this study was to examine the role interstitial collagenases, members family matrix metalloproteinases, in development pulmonary fibrosis. activity, levels and molecular forms collagenases (matrix metalloproteinases (MMP)-1, -8 -13), gelatinase B (MMP-9) its main endogenous inhibitor, tissue inhibitor metalloproteinase-1 (TIMP-1) were assessed bronchoalveolar lavage fluid (BALF) from patients with idiopathic fibrosis (IPF) sarcoidosis varying degrees parenchymal involvement....
There has been considerable disagreement about the prognostic value of bronchoalveolar lavage lymphocyte measurements in patients with sarcoidosis. This study looks at influence type disease presentation and time since onset symptoms on fluid profiles 99 studied their initial diagnosis. Patients who had an acute inflammatory erythema nodosum (n = 32) or uveitis 17) almost invariably high T helper:suppressor (TH:TS) ratios (mean 10.1, 95% confidence interval 7.7-12.5) a higher proportion...
BRITISH MEDICAL JOuRNAL VOLUmE 289 6 ocrom 1984 not seen in club scramblers.In this small series the incidence of injuries around right knee was high, and further work is being done to define injury patterns, mechanisms, possible preventive measures scrambling accidents all ages.Our purpose highlight these children, which do appear official road accident statistics.We have shown that they may be a substantial nature warrant study.We thank orthopaedic consultant staff for permission report on...
This study aimed at examining the mechanisms participating in excessive faecal bile acid loss cystic fibrosis. The was designed to define relation between fat and patients with without fibrosis related liver disease; assess terminal ileal absorption by a seven day whole body retention of selenium labelled homotaurocholic (SeHCAT); determine if small intestinal bacterial overgrowth contributes loss. population comprised 40 (27 men; median age 18 years) (n = 8) 32) disease eight control...
Cystic fibrosis has been reported to be associated with an increased prevalence of atopy and reversible airways obstruction. To determine whether such features can also result from other chronic suppurative lung infections, we studied 23 patients proved bronchiectasis, age sex matched normal controls. A personal or family history was equal frequency in the two groups. Although groups displayed a similar positive immediate hypersensitivity skinprick test responses, reacted more antigens (p...
The reported prevalence of interstitial lung disease in patients with rheumatoid arthritis has varied from 10% to 50%, yet less than 5% develop severe fibrosing disease. This suggests that subclinical may not always presage progressive Bronchoalveolar lavage fluid and either clinically evident or was examined for the presence factors a putative role development fibrosis. Patients were identified by prospective radiographic function screening 93 arthritis. Fourteen this manner an association...
Bronchoalveolar lavage fluid from 43 patients with biopsy proved sarcoidosis and 10 control subjects were assayed for fibronectin collagenase activity. Fibronectin was significantly increased in the group found to be positively correlated angiotensin converting enzyme activity, protein concentration, percentage of T cells helper:suppressor ratios fluid. Increased bronchoalveolar not related functional or radiographic indices interstitial disease did identify subsequently requiring treatment....
Ventilation and gas exchange during overnight sleep was studied in a group of seven patients with severe interstitial lung disease (mean vital capacity 50%, mean diffusing 46% predicted), to see whether clinically significant oxygen desaturation occurred. Patients history loud snoring or airflow obstruction were excluded. Sleep fragmented these patients, but all achieved rapid eye movement (REM) sleep. All showed episodes sleep--mean (SEM) awake arterial saturation (SaO2) 92.9% (0.3%)...
Repeated bouts of submaximal exercise are an important part most pulmonary rehabilitation programmes. Patients with moderate-to-severe cystic fibrosis (CF) often demonstrate oxygen desaturation during exercise, which may limit their ability to participate in these This study examines whether arterial contributes limitation by testing supplemental O 2 improves capacity. Eight patients CF (mean forced expiratory volume one second 41% predicted) each underwent two tests on a bicycle ergometer...
Summary We report a patient with both sarcoidosis and Crohn's colitis, an association not previously documented. review the literature discuss areas of overlap in these two conditions.
Pulmonary aspergillomas usually occur when Aspergillus fungi colonise lung tissue previously damaged by disease. in three adult patients with cystic fibrosis are reported--an association not described. At the time of diagnosis all had previous long term colonisation fumigatus and severe advanced destructive disease function less than 25% predicted normal values. It is likely that, increasing survival fibrosis, more will develop during protracted phase end stage that characterises terminal...