A5048024054- Neuroinflammation and Neurodegeneration Mechanisms
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Sphingolipid Metabolism and Signaling
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Hedgehog Signaling Pathway Studies
- Platelet Disorders and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Virus-based gene therapy research
- Respiratory viral infections research
- interferon and immune responses
- Hair Growth and Disorders
- T-cell and B-cell Immunology
- Cancer and Skin Lesions
Sanofi (United States)
2020-2024
AVEO Oncology (United States)
2021
Framingham State University
2021
Sanofi (Mexico)
2021
Curis (United States)
2005
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found affected brain regions, but how iron accumulation influences physiology and contributes to neurodegeneration is poorly understood. Here we show that human induced pluripotent stem cell-derived grown a tri-culture system highly responsive susceptible ferroptosis, an iron-dependent form of cell death. Furthermore, overload causes marked...
Abstract Microglia serve as the innate immune cells of central nervous system (CNS) by providing continuous surveillance CNS microenvironment and initiating defense mechanisms to protect tissue. Upon injury, microglia transition into an activated state altering their transcriptional profile, transforming morphology, producing pro-inflammatory cytokines. These initially a beneficial role, but continued activation drives neuroinflammation neurodegeneration. Multiple sclerosis (MS) is chronic,...
Nonhuman primates immunized with adjuvanted stabilized headless HA stem nanoparticles generated influenza-specific broadly neutralizing antibodies.
Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation these approaches used for antibody discovery is extensive process cloning expression involved transitioning from identification to validating function, which compromises throughput discovery. In this study, we describe a identify rapidly re-format express antibodies functional...
Abstract Immunization based antibody discovery is plagued by the paucity of antigen-specific B cells. Identifying these cells akin to finding needle in a haystack. Current and emerging technologies while effective, are limited terms capturing repertoire. We report on bulk purification B-cells benefits it offers various platforms. Using five different antigens, we show hit rates 51–88%, compared about 5% with conventional methods. also that this highly efficient loss only 2% antigen specific...
While significant advances have been made in understanding renal pathophysiology, less is known about the role of glycosphingolipid (GSL) metabolism driving organ dysfunction. Here, we used a small molecule inhibitor glucosylceramide synthase to modulate GSL levels three mouse models distinct pathologies: Alport syndrome (Col4a3 KO), polycystic kidney disease (Nek8jck), and steroid-resistant nephrotic (Nphs2 cKO). At tissue level, identified core immune-enriched transcriptional signature...
Abstract Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Multiple (MS). One prominent feature of affected brain regions are iron-loaded microglia, but how iron overload influences microglia physiology disease response is poorly understood. Here we show that highly susceptible to ferroptosis, an iron-dependent form cell death. In a tri-culture human iPSC-derived neurons, astrocytes,...
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