A5101563424- Force Microscopy Techniques and Applications
- Molecular Junctions and Nanostructures
- Neuroinflammation and Neurodegeneration Mechanisms
- Supercapacitor Materials and Fabrication
- Quantum Dots Synthesis And Properties
- Advanced battery technologies research
- Graphene research and applications
- Alzheimer's disease research and treatments
- Surface Chemistry and Catalysis
- Lipid Membrane Structure and Behavior
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytomegalovirus and herpesvirus research
- Sphingolipid Metabolism and Signaling
- thermodynamics and calorimetric analyses
- Layered Double Hydroxides Synthesis and Applications
- Ferroelectric and Negative Capacitance Devices
- Cellular Mechanics and Interactions
- Electrodeposition and Electroless Coatings
- RNA regulation and disease
- Magnetic Properties and Applications
- Photonic Crystals and Applications
- Ferroptosis and cancer prognosis
- Photoacoustic and Ultrasonic Imaging
- Electrochemical sensors and biosensors
- Non-Destructive Testing Techniques
Sanofi (United States)
2022-2024
Nanchang Institute of Technology
2024
Chinese Academy of Sciences
1997-2023
Changchun Institute of Applied Chemistry
2003-2023
University of Science and Technology of China
2019-2021
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found affected brain regions, but how iron accumulation influences physiology and contributes to neurodegeneration is poorly understood. Here we show that human induced pluripotent stem cell-derived grown a tri-culture system highly responsive susceptible ferroptosis, an iron-dependent form of cell death. Furthermore, overload causes marked...
Metachromatic leukodystrophy (MLD) is an autosomal recessive neurodegenerative disorder caused by mutations in the arylsulfatase A (ARSA) gene, resulting lower sulfatase activity and toxic accumulation of sulfatides central peripheral nervous system. Children account for 70% cases become progressively disabled with death occurring within 10 years disease onset. Gene therapy approaches to restore ARSA expression via adeno-associated viral vectors (AAV) have been promising but hampered limited...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron loss. Microglia and astrocyte-driven neuroinflammation prominent in ALS, but the cell state dynamics pathways driving remain unclear. We performed single-nucleus RNA sequencing of ALS spinal cords identified altered glial states, including increased expression inflammatory activation markers. Many these signals converged on inflammation death regulator receptor-interacting protein...
Rural industrial integration land has emerged with the rise of new industries in rural China, exhibiting spatial distribution patterns distinct from traditional land. However, research on this use remains limited. This paper offers an exploratory definition land, takes three typical villages Qingdao, Shandong Province as examples, establishes a model for measuring diversity, complexity, and compatibility development based Hill numbers diversity measurement model, information entropy index,...
A microcantilever array biosensor based on a sandwich structure has been developed for simultaneously measuring two biomarkers carcinoembryonic antigen (CEA) and α-fetoprotein (AFP) via an optical readout technique—real-time monitoring of the profile cantilever. First, aptamers CEA AFP were self-assembled their respective cantilevers. After adsorption mixture AFP, further specific interaction was performed addition antibodies to each target. The compressive stress cantilever generated by...
Hyperthermia-induced overexpression of heat shock protein 70 (HSP70) leads to the thermoresistance cancer cells and reduces efficiency photothermal therapy (PTT). In contrast, cell-specific membrane-associated HSP70 has been proven activate antitumor immune responses. The dual effect on inspires us that in-depth research membrane (mHSP70) during PTT treatment is essential. this work, a platform for human breast (MCF-7 cells) based mPEG-NH2-modified polydopamine (PDA)-coated gold nanorod...
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes motor neuron loss in the brain and spinal cord. Neuroinflammation driven by activated microglia astrocytes prominent ALS, but an understanding of cell state dynamics which pathways contribute to remains unclear. Single nucleus RNA sequencing ALS cords demonstrated striking changes glial states, including increased expression inflammatory activation markers. Many these signals converged on...
With excellent electrochemical activity, low consumption, and easy synthesis, Co-based layered double hydroxides (LDHs) have been applied to energy conversion storage devices. Understanding the mechanisms of morphological evolution capacity changes under potential cycles is critical for design high-performance materials LDHs. Here, we monitored two kinds CoFe-LDH nanosheets four CoAl-LDH using in situ electrochemical-atomic force microscopy. The present growth granular particles...
The growth kinetics of self-assembled monolayers formed by exposing freshly cleaved mica to octanol solution has been studied atomic force microscopy (AFM) and Fourier-transform infrared spectroscopy (FTIR). AFM images samples immersed in for varying exposure times showed that before forming a complete monolayer the molecules aggregated form small islands on surface. With proceeding immersion, these gradually grew merged into larger patches. Finally, close-packed film with uniform appearance...
Tumor-associated epithelial-mesenchymal transition (EMT) contains a set of transitional cellular states usually judged by the EMT marker expression. E-cadherin is down-regulated epithelial marker, and detection challenging on cancer cell surfaces in middle late stages EMT. Here, trace E-cadherins living bladder T24 surface during were investigated with force–distance curve-based atomic force microscopy. The results confirmed that cells are still an intermediate state can be transferred into...
Nickel-aluminum layered double hydroxides (Ni-Al LDHs) are widely used in energy storage and conversion devices, the impact of Ni/Al molar ratio on structural evolution kinetic process is great significance for improving reaction kinetics efficiency. In this paper, morphological evolutions nanomechanical property changes Ni-Al-n LDH (n ratio) nanosheets during potential cycling were explored by situ electrochemical atomic force microscopy. The Ni2+ into Ni3+ amphoteric properties Al3+...
The replacement of coronene monolayer on Au (111) by 6-mercapto-1-hexanol (MHO) was studied in situ scanning tunneling microscopy (STM) solutions. It found that the rate depends strongly concentration MHO. finished within a second at higher At lower concentration, slow could be followed STM. occurred initially near elbow position reconstructed with formation pits single or several missing molecules. With proceeding replacement, these small expanded, and surrounding molecules were gradually...
Understanding of the surface mechanism electrode materials based on MXenes, such as morphological evolution, is great significance for improving reaction kinetics and efficiency. In this paper, evolutions Ti3C2Tx nanosheets Fe3O4/Ti3C2Tx nanocomposites during potential cycling were explored by electrochemical atomic force microscopy first time. The oxidation Fe in situ Fe3O4 to FeOOH accumulation resulted appearance deposits surface. After 70 cycles, cracks formed nanocomposites, which might...
The structure of a Galfenol torque sensor is designed based on the inverse magnetostriction effect, thickness and grid width patch are optimized through Comsol finite element simulation. experimental platform built according to simulation results. deformation sensitive using increased by 9.82% compared thin plate structure; Compared not widening bottom magnetic choke, stress choke reduced 54%. research in this paper shows that has high precision small range measurement, which provides...
Adrenoleukodystrophy (ALD) is a rare neurometabolic disease caused by mutations in the ABCD1 gene, which encodes for peroxisomal very long chain fatty acid (VLCFAs) transporter. It debilitating disorder, has spectrum of clinical presentations. The most severe form rapidly progressing demyelinating called cerebral ALD or CALD. Patients with cALD have life expectancy 2-4 years after onset and symptoms often manifest childhood. other forms are adrenomyeloneuropathy AMN, slower degeneration...
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated cell-death several neurologic diseases. often analyzed tissue, but this approach fails to resolve cell-type differences likely essential understanding non-cell autonomous contributions neurodegeneration. We show human iPSC-derived neurons glia differ their rate of isoform composition, responses altered levels. RNA-sequencing cells treated...