A5100750989- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Molecular Junctions and Nanostructures
- Nanoplatforms for cancer theranostics
- Electrochemical Analysis and Applications
- Molecular Sensors and Ion Detection
- DNA and Biological Computing
- Nanocluster Synthesis and Applications
- Electrochemical sensors and biosensors
- DNA and Nucleic Acid Chemistry
- Carbon and Quantum Dots Applications
- Cancer-related molecular mechanisms research
- Analytical Chemistry and Sensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Metabolomics and Mass Spectrometry Studies
- Electrocatalysts for Energy Conversion
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- SARS-CoV-2 detection and testing
- Conducting polymers and applications
- MicroRNA in disease regulation
- Force Microscopy Techniques and Applications
- Circular RNAs in diseases
- Cancer survivorship and care
First Affiliated Hospital of Zhengzhou University
2017-2025
Fudan University
2022-2025
Tianjin University of Science and Technology
2015-2024
Yunnan University
2024
Huazhong University of Science and Technology
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Dongguan University of Technology
2024
Dalian Medical University
2016-2024
University of South China
2024
Fujian Medical University
2016-2024
Abstract Pathogenic infections seriously threaten public health and have been considered as one of the most critical challenges in clinical therapy. Construction a safe efficient photothermal antibacterial platform is promising strategy for treatment bacterial infections. Considering that high temperature does harm to normal tissues cells, herein, bacteria‐triggered multifunctional hydrogel constructed low‐temperature sterilization with efficiency by integrating localized chemodynamic...
In this present work, we proposed a colorimetric strategy for simultaneous detection of histidine and cysteine based on G-quadruplex-Cu(II) metalloenzyme the first time. Because adding or cysteine, formation will be disturbed, thus catalytic activity to TMB-H2O2 reaction is inversely proportional concentration cysteine. With strategy, limit in experimental measurement 10 nM 5 nM, respectively, which are both lower than previous arrays. help NEM, alkylated between Cu2+ inhibited, so...
Systemic immune-inflammation index (SII) is a new systemic inflammatory prognostic indicator associated with outcomes in patients different tumors. Studies have shown an association between SII and many chronic/acute diseases. This study aimed at exploring whether can be used as effective parameter for predicting the severity of acute pancreatitis (AP).A total 101 were enrolled this (mild (MAP): n = 73 severe (SAP): 28). Patient demographics analyzed using chi-square test, Student's t-test,...
Bacterial infections seriously threaten human health and also bring huge financial burden. It is critical to construct multifunctional platforms for effectively inactivating bacteria right after point-of-care testing (POCT). Chemiluminescence (CL) bioassays are considered as powerful candidates POCT they free from using an excitation light source, while the flash-type emission limits their further application. Herein, a CL system with long, persistent, intensive intensity was constructed...
Paramagnetic complexes containing gadolinium ions have been widely used for magnetic resonance imaging (MRI) in clinic. However, these paramagnetic pose some safety concerns. There is still a demand the development of stable MRI contrast agents that exhibit higher sensitivity and superior functionality to existing agents. Here, we develop carbonized manganese (II) (Mn@CCs) encapsulate Mn
The rapid identification and antibiotic susceptibility testing (AST) of bacteria would help us to accurately identify the infectious sources as well guide use antibiotics, which are crucial for improving survival rate antimicrobial resistance. Herein, a colorimetric sensor array fingerprinting was constructed with d-amino acid (d-AA)-modified gold nanoparticles (AuNPs) probes (Au/d-AA). Bacteria can metabolize d-AA, triggering aggregation AuNPs. Making different metabolic capabilities toward...
Pathogenic bacteria are widely distributed in diverse environments and significantly threaten human health. Point-of-care testing (POCT) is a valuable way for early warnings of threat. Herein, chemiluminescence (CL)-based ratiometric sensing platform was constructed sensitive POCT according to newly designed aggregation-induced emission (AIE) molecule. The new AIE molecule presents oxidase-like properties (named as AIEzyme) can trigger long persistent CL luminol (LUM) with strong intensity...
DNA-based molecular logic computation has drawn extensive attention in bioanalysis, intelligent diagnostics of diseases and other nanotechnology areas. Herein, taking 2-to-1 4-to-2 encoders a 1-to-2 decoder as model devices, we for the first time combined quenching ability GO (graphene oxide) to DNA-templated AgNCs with G-quadruplex-enhanced fluorescence intensity porphyrin dyes construction label-free enzyme-free dual-output advanced DNA devices. Also, through application negative...
A set of basic logic gates was constructed on a simple and universal DNA-AgNCs platform, further integrated into advanced circuits for DNA computing biosensing.
A label-free and enzyme-free three-input majority logic gate with one-vote veto function was developed for the first time.
Herein, an interference-free surface-enhanced Raman scattering (SERS) platform with a "sandwich" structure has been developed for reliable detection and photothermal killing of bacteria whole blood as the real sample. The multifunctional comprised plasmonic gold film (pAu) functionalized bacteria-capturing units 4-mercaptophenylboronic acid internal reference 4-mercaptobenzonitrile SERS substrate vancomycin-modified core (gold)–shell (Prussian blue) nanoparticles (Au@PB@Van NPs) tag....
Precisely locating tumor site based on tumor-microenvironment-induced (TMI) multimodal imaging is especially interesting for accurate and efficient cancer therapy. In the present investigation, a novel TMI all-in-one nanoplatform, CuSNC@DOX@MnO2-NS, has been successfully fabricated chemical photothermal (Chem-PTT) therapy guided by site. Here, CuS nanocages with mesoporous hollow structure (CuSNC) acting as nanocarriers provide high capacity loading anticancer drug, doxorubicin (DOX). The...
Simple and efficient identification of multiple bacteria sterilization in real time is considerable significance for clinical diagnostics quality control food. Herein, a novel chemical-tongue sensor array with 3,3',5,5'-tetramethylbenzidine (TMB) as single probe was developed bacterial photothermal elimination. The synthesized bimetallic palladium/platinum nanoparticles (Pd/PtNPs) present excellent catalytic capability that can catalyze TMB into oxidized (oxTMB) four feature absorption...
Abstract Nanozymes capable of generating reactive oxygen species have recently emerged as promising treatments for wounds infected with drug‐resistant bacteria, possessing a reduced possibility inducing resistance. However, the therapeutic effect is limited by shortage endogenous oxy‐substrates and undesirable off‐target biotoxicity. Herein, ferrocenyl coordination polymer (FeCP) nanozyme, featuring pH switchable peroxidase (POD)‐ catalase (CAT)‐like activity incorporated indocyanine green...