An Fe-doped CoP nanoarray behaves as a robust 3D monolithic multifunctional catalyst for electrolytic and hydrolytic hydrogen evolution with high activity. Its two-electrode electrolyzer needs cell voltage of only 1.60 V 10 mA cm-2 water-splitting current. It also catalyzes effectively NaBH4 hydrolysis low activation energy ≈39.6 kJ mol-1 generation rate 6.06 L min-1 g-1 .

Replacement of precious Pt with earth-abundant electrocatalysts for the hydrogen evolution reaction (HER) holds great promise clean energy devices, but development low-cost and durable HER catalysts Pt-like activity is still a huge challenge. In this communication, we report on self-standing ternary FexCo1–xP nanowire array carbon cloth (FexCo1–xP/CC) as Pt-free catalyst activities being strongly related to Fe substitution ratio. Electrochemical tests show that Fe0.5Co0.5P/CC not only...

The generation of singlet oxygen (1 O2 ) during photodynamic therapy is limited by the precise cooperation light, photosensitizer, and oxygen, therapeutic efficiency restricted elevated glutathione (GSH) levels in cancer cells. Herein, we report that an ultrathin two-dimensional metal-organic framework Cu-TCPP nanosheets (TCPP=tetrakis(4-carboxyphenyl)porphyrin) can selectively generate 1 a tumor microenvironment. This process based on peroxidation TCPP ligand acidic H2 followed reduction to...

It is well-known that nanomaterials are capable of entering living cells, often by utilizing the cells' endocytic mechanisms. Passive penetration lipid bilayer may, however, occur as an alternative process. Here we have focused on passive transport small nanoparticles across plasma membranes red blood which incapable endocytosis. By using fluorescence microscopy, observed zwitterionic quantum dots penetrate through cell so they can be found inside cells. The penetration-induced structural...

Uptake and intracellular transport of D-penicillamine coated quantum dots (DPA-QDs) 4 nm radius by live HeLa cells have been investigated systematically spinning disk 4Pi confocal microscopies. Unlike larger nanoparticles, these small DPA-QDs were observed to accumulate at the plasma membrane prior internalization, uptake efficiency scaled nonlinearly with nanoparticle concentration. Both observations indicate that a critical threshold density has be exceeded for triggering internalization...

The high levels of H2O2 are closely associated with cancer and progressive neurodegenerative diseases, such as Parkinson's disease. In this study, we developed a novel CuS nanoparticle-decorated reduced graphene oxide-based electrochemical biosensor for the reliable detection H2O2. new electrocatalyst, CuS/RGO composites was successfully prepared by heating mixture CuCl2 Na2S aqueous solutions in presence PVP-protected oxide at 180 °C. A potential application composite-modified electrode to...

Integration of multiple therapeutic/diagnostic modalities into a single system holds great promise to improve theranostic efficiency for tumors, but still remains technical challenge. Herein, we report new multimodal nanoconstruct based on Fe-doped polydiaminopyridine nanofusiforms, built easily and large scale, which can dual-regulate intracellular oxygen glutathione levels, transport iron ions, simultaneously be used thermal imaging magnetic resonance imaging. Co-loading dihydroartemisinin...

Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the accumulation PS within a tumor, thereby enhancing nonspecific in normal tissues, which inevitably leads to limited efficacy for photodynamic therapy (PDT) and enhanced systematic phototoxicity. Moreover, local hypoxia tumor tissue also seriously hinders PDT. To overcome these limitations, an acidic H 2 O ‐responsive ‐evolving core–shell PDT nanoplatform is developed by using MnO shell as switchable shield...

Intrinsically integrating precise diagnosis, effective therapy, and self-anti-inflammatory action into a single nanoparticle is attractive for tumor treatment future clinical application, but still remains great challenge. In this study, bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, high X-ray absorption coefficient were prepared through one-step biomineralization. The allow phototherapy...

Abstract Chaos and the natural evolution of tumor systems can lead to failure therapies. Herein, we demonstrate that iridium oxide nanoparticles (IrO x ) possess acid‐activated oxidase peroxidase‐like functions wide pH‐dependent catalase‐like properties. The integration glucose (GOD) unlocked peroxidase activities IrO by production gluconic acid from GOD catalysis in cancer cells, produced H 2 O was converted into compensate its consumption owing function nanozyme, thus resulting continual...

Nanoparticles are finding a rapidly expanding range of applications in research and technology, finally entering our daily life medical, cosmetic or food products. Their ability to invade all regions an organism including cells cellular organelles offers new strategies for medical diagnosis therapy (nanomedicine), but their safe use requires deep knowledge about interactions with biological systems at the molecular level. Upon incorporation, nanoparticles exposed fluids from which they...

With the rapid development of nanotechnology, mesoporous silica nanoparticles (MSNs) with numerous forms and structures have been synthesized extensively applied in biomedicine past decades. However, our knowledge about biocompatibility developed MSNs has not matched their development. Therefore, this work, we sphere-shaped different pore scales (s-SPs l-SPs) rod-shape (RPs-3) to evaluate influence morphology size on interaction serum proteins red blood cells (RBCs). The adsorption human...

We have investigated the uptake of cationic polystyrene nanoparticles by mesenchymal stem cells (MSCs) using confocal fluorescence microscopy and flow cytometry. Two types about 100 nm diameter with similar zeta potentials were employed in this study, plain (PS) amino-functionalized (NPS) nanoparticles, each carrying 6000 amino groups on surface. To assess relative importance specific endocytosis mechanisms, was observed presence drugs dynasore chlorpromazine. NPS rapidly internalized...

Local hypoxia in tumors, as well the short lifetime and limited action region of 1 O2 , are undesirable impediments for photodynamic therapy (PDT), leading to a greatly reduced effectiveness. To overcome these adversities, mitochondria-targeting, H2 -activatable, -evolving PDT nanoplatform is developed based on FeIII -doped two-dimensional C3 N4 nanofusiform highly selective efficient cancer treatment. The ultrahigh surface area 2D nanosheets enhances photosensitizer (PS) loading capacity...

Recently, two-dimensional transition metal dichalcogenides (TMDCs) have been widely studied in biomedicine. In this article, we developed a new photothermal nanocarrier based on polydopamine coated selenide molybdenum (MoSe2@PDA) as an effective for loading anticancer drug doxorubicin (MoSe2@PDA-Dox). Conjugation of PDA onto the surface MoSe2 nanosheets can not only enhance effect and decrease its cytotoxicity but also provide anchor points Dox. The resulting MoSe2@PDA nanocomposites exhibit...

Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules disrupt the cells. Biomineralized oxidized (-)-epigallocatechin-3-o-gallate (EGCG)-molybdenum ion coordination nanoparticles were prepared disrupting redox equilibria simultaneously reacting with GSH in a Michael addition form large aggregates that mechanically endosomal...

Humans are threatened by bacteria and other microorganisms, resulting in countless pathogen-related infections illnesses. Accumulation of reactive oxygen species (ROS) infected wounds activates strong inflammatory responses. The overuse antibiotics has led to increasing bacterial resistance. Therefore, effective ROS scavenging bactericidal capacity essential the advanced development collaborative therapeutic techniques combat is needed. Here, this work developes an...

In situ and accurate measurement of the structure dynamics interfacial water in hydrogen evolution reaction (HER) is a well-known challenge because coupling among varied structures its dual role as reactants solvents. Further, interference bulk intricate interactions always hinders probing water. Surface-enhanced infrared absorption spectroscopy extremely sensitive for water; herein, we develop nanoconfinement strategy by introducing nonaqueous ionic liquids to decouple tailor electric...

The conformational changes of bovine heart cytochrome c (cyt c) induced by the adsorption on gold nanoparticles with different sizes have been investigated electronic absorption, circular dichroism (CD), and Fourier transform infrared spectra. combination these techniques can give complementary information about adsorption-induced changes. results show that there are for cyt adsorbed due to interaction forces between nanoparticles. colloidal concentration-dependent conformation distribution...