Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the accumulation PS within a tumor, thereby enhancing nonspecific in normal tissues, which inevitably leads to limited efficacy for photodynamic therapy (PDT) and enhanced systematic phototoxicity. Moreover, local hypoxia tumor tissue also seriously hinders PDT. To overcome these limitations, an acidic H 2 O ‐responsive ‐evolving core–shell PDT nanoplatform is developed by using MnO shell as switchable shield...

Abstract Chaos and the natural evolution of tumor systems can lead to failure therapies. Herein, we demonstrate that iridium oxide nanoparticles (IrO x ) possess acid‐activated oxidase peroxidase‐like functions wide pH‐dependent catalase‐like properties. The integration glucose (GOD) unlocked peroxidase activities IrO by production gluconic acid from GOD catalysis in cancer cells, produced H 2 O was converted into compensate its consumption owing function nanozyme, thus resulting continual...

Local hypoxia in tumors, as well the short lifetime and limited action region of 1 O2 , are undesirable impediments for photodynamic therapy (PDT), leading to a greatly reduced effectiveness. To overcome these adversities, mitochondria-targeting, H2 -activatable, -evolving PDT nanoplatform is developed based on FeIII -doped two-dimensional C3 N4 nanofusiform highly selective efficient cancer treatment. The ultrahigh surface area 2D nanosheets enhances photosensitizer (PS) loading capacity...

Abstract Background: To explore whether radiomics combined with computed tomography (CT) images can be used to establish a model for differentiating high grade (International Society of Urological Pathology [ISUP] III–IV) from low-grade (ISUP I–II) clear cell renal carcinoma (ccRCC). Methods: For this retrospective study, 3-phase contrast-enhanced CT were collected 227 patients pathologically confirmed ISUP-grade ccRCC (155 cases in the group and 72 high-grade group). First, we delineated...

In this article, a type of small-sized metal organic framework (MOF), MIL-101(Fe), as an intelligent delivery system was fabricated to load chemotherapy drug dihydroartemisinin (DHA) and photosensitizer methylene blue (MB). addition, the Fe ions releasedfrom MOFs in tumor environment not only enhanced curative effect DHA but also catalyzed H2O2 release O2, which further improved photodynamic therapeutic nanocomposites. The nanocomposites can serve T2 magnetic resonance imaging contrast agent...

Cadmium (Cd) contamination poses a substantial threat the environment, necessitating effective remediation strategies. Phytoremediation emerges as cost-efficient and eco-friendly approach for reducing Cd levels in soil. In this study, suitability of A. venetum ameliorating Cd-contaminated soils was evaluated. Mild stress promoted seedling root growth, with being identified primary tissue accumulation. The content roots ranged from 0.35 to 0.55 mg/g under treatment 10–50 µM CdCl2·2.5 H2O,...

Abstract Chaos and the natural evolution of tumor systems can lead to failure therapies. Herein, we demonstrate that iridium oxide nanoparticles (IrO x ) possess acid‐activated oxidase peroxidase‐like functions wide pH‐dependent catalase‐like properties. The integration glucose (GOD) unlocked peroxidase activities IrO by production gluconic acid from GOD catalysis in cancer cells, produced H 2 O was converted into compensate its consumption owing function nanozyme, thus resulting continual...

Regulating the metabolism-redox circuit of cancer cells has emerged as an attractive strategy to improve therapeutic outcome, while often confronting glaring issue resistance due multiple adaptive responses tumor cells. This study presents a simple yet efficient approach regulate this simultaneously against adaptability by utilizing polydopamine-encapsulated zinc peroxide nanoparticles (ZnO2@PDA NPs). The could deliver large amounts Zn2+ and H2O2 into unfold intracellular self-amplifying...

Achieving high-resolution imaging of bone-cracks and even monitoring them in live organisms are great significance for understanding their extreme biological effects but remain quite challenging, especially adopting commercial systems. Herein, we explore the use clinical gemstone spectral computed tomography (GSCT) technique as a powerful tool targeted rats via intramuscularly administrating crack-targeted ytterbium-based contrast agents (CAs). Material density images GSCT reveal that with...

Background Immunotherapy, adjuvant chemotherapy, and prognosis of colorectal cancer are associated with MSI. Biopsy pathology cannot fully reflect the MSI status heterogeneity rectal cancer. Purpose To develop a radiomic-based model to preoperatively predict in on MRI. Assessment The patients were divided into two cohorts (training testing) at 7:3 ratio. Radiomics features, including intensity, texture, shape, extracted from segmented volumes interest based T2-weighted ADC imaging....

Salt stress is a serious abiotic that primarily inhibits plant growth, resulting in severe yield losses. Our previous research found flavonoids play important roles A. venetum salt tolerance. In response to stress, we noted the flavonoid content was depleted venetum. However, detailed mechanism still not clear. this study, expression patterns of three synthetase genes, AvF3H, AvF3'H, and AvFLS were systemically analyzed under seedlings. The tolerance transgenic Arabidopsis plants improved by...

Purpose To investigate the feasibility of using quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to differentiate active and inactive stage sacroiliitis correlation between parameters disease activity as measured by clinical scores. Materials Methods Forty-two patients with ankylosing spondylitis underwent DCE-MRI on a 3.0T MRI unit. According results blood sedimentation rate (ESR), C-reactive protein (CRP), Bath Ankylosing Spondylitis Disease Activity Index...

Background Previous studies have confirmed the separate effect of arterial stiffness and obesity on type 2 diabetes; however, joint diabetes onset remains unclear. Objective This study aimed to propose concept phenotype explore risk stratification capacity for diabetes. Methods longitudinal cohort used baseline data 12,298 participants from Beijing Xiaotangshan Examination Center between 2008 2013 then annually followed them until incident or 2019. BMI (waist circumference) brachial-ankle...

Bi@C nanoparticles were fabricated at the gram scale through a one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy.

Abstract Single nanocarriers with intrinsic characteristics of diagnosis, effective therapy against solid malignancies fatal metastasis, and tumor microenvironment regulation are promising in construction a simple multimode nanotheranostic system. Herein, multi‐caged IrO x fabricated by direct thermal hydrolysis strategy, which exhibit good sono‐photodynamic response, outstanding gemstone spectral computed tomography, photoacoustic (PA) imaging capabilities, universal loading, pinpoint drug...

The penetration depth of near-infrared laser has greatly restricted the development most photothermal agents. Recently, agents in second (NIR-II) window have drawn great attention as they can overcome above barrier. Herein, a novel "all one" NIR-II responsive nanoplatform (nickel selenide @polydopamine nanocomposites, NiSe@PDA NCs) based on situ coating polydopamine (PDA) surface biomineralized nickel nanoparticles (NiSe NPs) for dual-model imaging-guided therapy is reported. Under...

// Le Zhou 1 , Mengchao Zhang 2 Qingfeng Fu Jingting Li Hui Sun Department of Thyroid Surgery, China-Japan Union Hospital, Jilin University, Provincial Key Laboratory Surgical Translational Medicine, Changchun 130033, China Radiology Department, Correspondence to: Sun, e-mail: cc_sunhui@163.com Keywords: IR820, amino-glucose, near infrared hyperthermia, tumor targeting, heat shock protein 70 Received: June 18, 2015 Accepted: December 29, Published: January 12, 2016 ABSTRACT Treatment thyroid...

Phrenic nerve injury and diaphragmatic stimulation are common complications following arrhythmia ablation pacing therapies. Preoperative comprehension of phrenic anatomy via non-invasive CT imaging may help to minimize the electrophysiological procedure-related complications.Coronary angiography data 121 consecutive patients were collected. Imaging left right pericardiophrenic bundles was performed with volume rendering multi-planar reformation techniques. The shortest spatial distances...

Background Lymphovascular space invasion (LVSI) is a risk factor for poor prognosis of cervical cancer. Preoperative identification LVSI very difficult. Purpose To evaluate the potential extracellular volume (ECV) fraction based on T1 mapping in preoperative cancer compared with dynamic contrast‐enhanced MRI (DCE‐MRI). Study Type Retrospective. Subjects A total 79 patients (median age 54 years) were classified into group ( n = 29) and without 50) according to postoperative pathology. Field...

Abstract Parkinson's disease (PD) is an age‐related progressive neurodegenerative disorder characterized by both motor and non‐motor symptoms resulting from the death of dopaminergic neurons in substantia nigra pars compacta (SNpc) noradrenergic locus coeruleus (LC). The current diagnosis PD primarily relies on symptoms, often leading to diagnoses advanced stages, where a significant portion SNpc dopamine has already succumbed. Therefore, identification imaging biomarkers for early‐stage...

Apathy is among the most prevalent and incapacitating non-motor symptoms of Parkinson's disease (PD). PD patients with apathy (PD-A) have been reported to abnormal spontaneous brain activity mainly in 0.01-0.08 Hz. However, frequency-dependence PD-A remains unclear. Therefore, this study aimed examine whether abnormalities are associated specific frequency bands.Overall, 28 PD-A, 19 without (PD-NA), 32 gender-, age-matched healthy controls (HCs) were enrolled. We collected resting-state...