A5066181556- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Single-cell and spatial transcriptomics
- Nanowire Synthesis and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Management of metastatic bone disease
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Modular Robots and Swarm Intelligence
- Glioma Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Chronic Lymphocytic Leukemia Research
- Gene Regulatory Network Analysis
- Occupational exposure and asthma
- Molecular Junctions and Nanostructures
- Endometriosis Research and Treatment
- Advanced Fiber Laser Technologies
- Viral-associated cancers and disorders
- Semiconductor materials and devices
- Cell Image Analysis Techniques
Sanofi (United States)
2024
Harvard University
1997-2024
Neurological Surgery
2022-2023
University of California, San Francisco
2022-2023
Boston VA Research Institute
2020-2022
University of California, Los Angeles
2022
University of California, Berkeley
1997-2012
Duke University
2008
Mount Sinai Hospital
1997
Med Center
1997
IL-4 and IL-13 have non-redundant effects in olfaction, with loss of smell mice evoked only by intranasal administration IL-4, but not IL-13. IL-4-evoked pathophysiological on olfaction is independent compromised structural integrity the olfactory neuroepithelium. IL-4-IL-4Rα signaling modulates neuronal crosstalk immune cells, suggesting a functional link between impairment neuroinflammation. Abbreviations: IL, interleukin; KO, knock-out; wk, week; WT, wild-type.
We describe a method to pattern SiO2 surfaces with colloidal gold nanoparticles by e-beam lithography and selective nanoparticle deposition. The simple technique allows us deposit in continuous straight lines, just one wide many long. contact the prepositioned metal leads form single electron transistors. Coulomb blockade surprisingly does not show parasitic “offset charges” at low temperatures, indicating relatively little surface contamination.
Wound complications are a common adverse event following metastatic spine tumor surgery. Some patients with spinal metastases may first undergo radiation but eventually require surgery because of either cord compression or instability. The authors compared wound complication rates in who had undergone for disease and received preoperative treatments, postoperative radiation, no radiation.
Multicellular organisms originate from a single cell, ultimately giving rise to mature of heterogeneous cell type composition in complex structures. Recent work the areas stem biology and tissue engineering has laid major groundwork ability convert certain types cells into other types, but there been limited progress control morphology cellular masses as they grow. Contemporary approaches this problem have included use artificial scaffolds, 3D bioprinting, media formulations; however, are no...
Abstract The ability to differentiate stem cells into human cell types is essential define basic mechanisms and therapeutics, especially for not routinely accessible by biopsies. But while engineered expression of transcription factors (TFs) identified through TF screens has been found rapidly efficiently produce some types, generation other that require complex combinations TFs elusive. Here we develop an iterative, pooled single-cell screening method improves the identification effective...
In the absence of spinal cord compression, it is unclear if surgery more effective than radiation treatment for improving functional outcomes in metastatic tumor patients with potentially unstable spines. The authors compared status assessed Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group (ECOG) scores after or without compression Spine Instability Neoplastic Score (SINS) values 7-12 indicating possible instability (SINS 7-12).A retrospective review was performed...
This report presents a mortality study among the 17,344 members of Construction Workers' Health Insurance Society Mie Prefecture in Japan. The period was between 1973 and 1993. During this period, 480 died. Age-specific rates were used as comparison standards. Significantly elevated standardized ratio (SMR) proportionate (PMR) observed for "accidents adverse effects." In addition, PMRs all cancers "cancers trachea, bronchus lung" also significantly elevated. job classifications reorganized...
Abstract Simultaneous differentiation of human induced pluripotent stem cells (hiPSCs) into divergent cell types offers a pathway to achieving tailorable cellular complexity, patterned architecture, and function in engineered organoids tissues. Recent transcription factor (TF) overexpression protocols typically produce only one type interest rather than the multitude structural organization found native Here, we report an orthogonal platform for genomically programming cells, bioprinted...
A bstract Multi-cellular organisms originate from a single cell, ultimately giving rise to mature of heterogeneous cell type composition in complex structures. Recent work the areas stem biology and tissue engineering have laid major groundwork ability convert certain types cells into other types, but there has been limited progress control morphology cellular masses as they grow. Contemporary approaches this problem included use artificial scaffolds, 3D bioprinting, media formulations,...
Cell-matrix interactions mediate complex physiological processes through biochemical, mechanical, and geometrical cues, influencing pathological changes therapeutic responses. Accounting for matrix effects earlier in the drug development pipeline is expected to increase likelihood of clinical success novel therapeutics. Biomaterial-based strategies recapitulating specific tissue microenvironments 3D cell culture exist but integrating these with 2D methods primarily used screening has been...
Tawil, Michael BS*; Sorour, Omar BA‡; Morshed, Ramin MD*; Huang, Jeremy Agarwal, Nitin Shabani, Saman Theodosopoulos, Philip Mummaneni, Praveen MD, MBA* Author Information
BACKGROUND: Although HD is not considered an AIDS-defining malignancy, several studies have shown a statistically increased incidence of in HIV infected patients, versus uninfected controls (Lyter, JCO 13:2540, 1995). Small series confirmed that most HIV+ patients with extensive, extra-nodal disease, shorter survival than expected "de novo" disease. No large has yet examined the results standard ABVD chemotherapy patients. METHODS: path diagnosis were eligible, if previously untreated....
Adrenoleukodystrophy (ALD) is a rare neurometabolic disease caused by mutations in the ABCD1 gene, which encodes for peroxisomal very long chain fatty acid (VLCFAs) transporter. It debilitating disorder, has spectrum of clinical presentations. The most severe form rapidly progressing demyelinating called cerebral ALD or CALD. Patients with cALD have life expectancy 2-4 years after onset and symptoms often manifest childhood. other forms are adrenomyeloneuropathy AMN, slower degeneration...
Cell-matrix interactions mediate complex physiological processes through biochemical, mechanical, and geometrical cues, influencing pathological changes therapeutic responses. Accounting for matrix effects earlier in the drug development pipeline is expected to increase likelihood of clinical success novel therapeutics. Biomaterial-based strategies recapitulating specific tissue microenvironments 3D cell culture exist but integrating these with 2D methods primarily used screening has been...
We present wafer-scale processed optomechanical oscillators with low threshold power (<;120μW) owing to high Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">optical</sub> = 5.3M, phase noise of -110dBc/Hz (10kHz offset, 18.6MHz carrier). Phase is modeled, and measured vs. Qmechanical.