A5086288143- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Aortic Disease and Treatment Approaches
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Developmental Biology and Gene Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Pluripotent Stem Cells Research
- Additive Manufacturing and 3D Printing Technologies
- Radiology practices and education
- Innovative Microfluidic and Catalytic Techniques Innovation
- Planarian Biology and Electrostimulation
- Congenital Heart Disease Studies
- Child Nutrition and Feeding Issues
- Healthcare Systems and Reforms
- Congenital Anomalies and Fetal Surgery
- Infant Nutrition and Health
- Intramuscular injections and effects
- Heparin-Induced Thrombocytopenia and Thrombosis
- Infective Endocarditis Diagnosis and Management
- Innovations in Medical Education
- Social Media in Health Education
- Vascular anomalies and interventions
Harvard University
2019-2024
Massachusetts General Hospital
2021-2024
Johns Hopkins Medicine
2018-2021
Johns Hopkins University
2018-2021
Johns Hopkins Hospital
2018-2021
Washington University in St. Louis
2018
Engineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and maintenance of densely cellular constructs composed ~108 cells/ml. Organ building blocks (OBBs) patient-specific-induced pluripotent stem cell-derived organoids offer pathway to achieving with requisite density, microarchitecture, function. However, date, scant attention has been devoted their assembly into 3D tissue constructs. Here, we report biomanufacturing method...
The aim of the study was to characterize enteral feeding practices in infants after gastrointestinal surgery.We performed a retrospective analysis who underwent intestinal surgery at age <6 months survived be fed enterally between January 2012 and June 2017. Demographics, surgical characteristics, practices, growth-related outcomes during hospitalization, discharge, follow-up (3, 6, 12 months) were obtained from electronic medical records. Descriptive statistics compared by their initial...
Abstract Simultaneous differentiation of human induced pluripotent stem cells (hiPSCs) into divergent cell types offers a pathway to achieving tailorable cellular complexity, patterned architecture, and function in engineered organoids tissues. Recent transcription factor (TF) overexpression protocols typically produce only one type interest rather than the multitude structural organization found native Here, we report an orthogonal platform for genomically programming cells, bioprinted...
The Notch pathway is an ancient intercellular signaling system with crucial roles in numerous cell-fate decision processes across species. While the canonical activated by ligand-induced cleavage and nuclear localization of membrane-bound Notch, can also exert its activity a ligand/transcription-independent fashion, which conserved Drosophila, Xenopus, mammals. However, noncanonical role remains poorly understood vivo processes. Here we show that increased levels intracellular domain (NICD)...
The Notch pathway is an ancient intercellular signaling system with crucial roles in numerous cell-fate decision processes across species. While the canonical activated by ligand-induced cleavage and nuclear localization of membrane-bound Notch, can also exert its activity a ligand/transcription-independent fashion, which conserved Drosophila, Xenopus, mammals. However, noncanonical role remains poorly understood vivo processes. Here we show that increased levels intracellular domain (NICD)...