A5092490538- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Photoreceptor and optogenetics research
- Cancer Cells and Metastasis
- Neural Networks and Applications
- Neuroscience and Neuropharmacology Research
- Embodied and Extended Cognition
- Planarian Biology and Electrostimulation
- EEG and Brain-Computer Interfaces
The University of Tokyo
2023-2025
Laboratory for Integrated Micro-Mechatronic Systems
2023-2025
Harvard University
2020
Abstract An inter-regional cortical tract is one of the most fundamental architectural motifs that integrates neural circuits to orchestrate and generate complex functions human brain. To understand mechanistic significance projections on development circuits, we investigated an in vitro tissue model for connections, which two cerebral organoids are connected with a bundle reciprocally extended axons. The produced more intense oscillatory activity than conventional or directly fused...
Abstract Characterization and modeling of biological neural networks has emerged as a field driving significant advancements in our understanding brain function related pathologies. As today, pharmacological treatments for neurological disorders remain limited, pushing the exploration promising alternative approaches such electroceutics. Recent research bioelectronics neuromorphic engineering have fostered development new generation neuroprostheses repair. However, achieving their full...
Abstract Microelectrode array (MEA) techniques provide a powerful method for exploration of neural network dynamics. A critical challenge is to interface 3D tissues including organoids with the flat MEAs surface, as it essential place neurons near electrodes recording weak extracellular signals neurons. To enhance performance MEAs, most research have focused on improving their surface treatment, while little attention has been given improve tissue‐MEA interactions from medium side. Here,...
Neural organoids form complex networks but lack external stimuli and hierarchical structures crucial for refining functional microcircuits. In this study, we modeled the modular network organization by connecting multiple tested if connection enhances stimuli-induced refinement. We cultured of one, two, or three on high-density microelectrode arrays, applied repetitive stimulation at two input locations from microelectrodes, monitored emergence output signals that can decode stimulus with...
Abstract Simultaneous differentiation of human induced pluripotent stem cells (hiPSCs) into divergent cell types offers a pathway to achieving tailorable cellular complexity, patterned architecture, and function in engineered organoids tissues. Recent transcription factor (TF) overexpression protocols typically produce only one type interest rather than the multitude structural organization found native Here, we report an orthogonal platform for genomically programming cells, bioprinted...
Motor nerve organoids could be generated by culturing a spheroid of motor neurons differentiated from human induced pluripotent stem (iPS) cells within polydimethylsiloxane (PDMS) chip which guides direction and fasciculation axons extended the spheroid. To isolate axon bundles organoids, we developed rapid laser dissection method based on localized photothermal combustion. By illuminating blue black mark culture device using dry-erase marker, highly heating near bundles. Moving enabled...
Abstract Characterization and modeling of biological neural networks has emerged as a field driving significant advancements in our understanding brain function related pathologies. As today, pharmacological treatments for neurological disorders remain limited, pushing the exploration promising alternative approaches such electroceutics. Recent research bioelectronics neuromorphic engineering have led to design new generation neuroprostheses repair. However, its complete development requires...
<title>Abstract</title> Characterization and modeling of biological neural networks is a field opening to major advances in our understanding the mechanisms governing functioning brain different pathologies that can affect it. Recent researches bioelectronics neuromorphic engineering lead design new generation neuroprosthesis. Here we show novel real-time, biomimetic energy-efficient network for bio-hybrid experiments parallel emulation. This system used investigate reproduce dynamics. The...
"Talking with Neurons" is an interactive installation that enables people to remotely connect live neural tissues mimic our nervous system. Audiences activate lab-grown circuits called organoids in off-site lab through their vocal cues. The neurons respond this stimulation by exhibiting patterns of activity are subsequently translated into audiovisual representations. Essentially, talk the neurons, which then promptly audience.