A5033717070- Pluripotent Stem Cells Research
- Zebrafish Biomedical Research Applications
- Gastrointestinal motility and disorders
- Infant Health and Development
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Chromatin Dynamics
Wyss Institute for Biologically Inspired Engineering
2023
Boston VA Research Institute
2022
Harvard University
2022
Bipolar disorder (BD) is a severe psychiatric condition marked by episodes of mania and depression, with neurotransmitter imbalance in the midbrain believed to play critical role its pathophysiology. Despite this, there currently no validated model for examining BD-associated molecular changes available. Leveraging recent advances stem cell technology, we developed organoid using human induced pluripotent cells (hiPSCs) from BD patients healthy controls (CTR). To address issues variability...
Abstract The ability to differentiate stem cells into human cell types is essential define basic mechanisms and therapeutics, especially for not routinely accessible by biopsies. But while engineered expression of transcription factors (TFs) identified through TF screens has been found rapidly efficiently produce some types, generation other that require complex combinations TFs elusive. Here we develop an iterative, pooled single-cell screening method improves the identification effective...