A5100360986- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Neural dynamics and brain function
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Photoreceptor and optogenetics research
- Axon Guidance and Neuronal Signaling
- Neuropeptides and Animal Physiology
University of California, San Francisco
2003-2025
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Hebei Medical University
2011-2024
Queen's Medical Centre
2020-2024
University of Washington
2009-2024
Command Hospital
2024
Versus Arthritis
2020-2024
University of Nottingham
2024
Zhejiang University
2022-2024
Bone fracture at the acute stage of stroke exacerbates injury by increasing neuroinflammation. We hypothesize that activation α-7 nicotinic acetylcholine receptor (α-7 nAchR) attenuates neuroinflammation and oxidative stress, reduces brain in mice with bone stroke. Permanent middle cerebral artery occlusion (pMCAO) was performed C57BL/6J followed tibia 1 day later. Mice were treated 0.8 mg/kg PHA 568487 (PHA, nAchR-specific agonist), 6 methyllycaconitine nAchR antagonist), or saline 2 days...
Abstract As the primary source of norepinephrine (NE) in brain, locus coeruleus (LC) regulates both arousal and stress responses 1,2 . However, how local neuromodulatory inputs contribute to LC function remains unresolved. Here we identify a network transcriptionally functionally diverse GABAergic neurons dendritic field that integrate distant modulate modes firing control arousal. We define peri-LC anatomy using viral tracing combine single-cell RNA sequencing spatial transcriptomics...
Mitochondria damage and apoptosis were found associated with sevoflurane induced neurotoxicity in developing brains of rodent neuro cell lines. The detailed upstream mechanism remains unclear. This study explored whether induces by activating a GSK3β (glycogen synthase kinase 3β)/Drp1 (dynamin-related protein-1)-dependent mitochondrial fission apoptosis. Our results showed that exposure promoted mitochondria hippocampus neonatal mice, resulted prolonged escape latency from P32...
Currently, the most effective strategy for dealing with Alzheimer's disease (AD) is delaying onset of dementia. Severe hypoglycemia strongly associated dementia; however, effects recurrent moderate (RH) on progression cognitive deficits in patients diabetes genetic susceptibility to AD remain unclear. Here, we report that insulin-controlled hyperglycemia slightly aggravated AD-type pathologies and impairment; RH significantly increased neuronal hyperactivity accelerated...
Neuropathic pain as a complex chronic disease that occurs after neurological injury, however the underlying mechanisms are not clarified in detail, hence therapeutic options limited. The purpose of this study was to explore potential hub genes for neuropathic and evaluate clinical application these predicting pain.Differentially expressed analysis weighted gene co-expression network (WGCNA) used new susceptibility modules genes. KEGG GO analyses utilized role Nomogram model ROC curves...
Abstract Skeletal muscular atrophy is a complex disease involving large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, effective therapeutic approaches are yet to be established. Recent studies have shown that epigenetics play an important role in regulating skeletal muscle atrophy, influencing the numerous genes associated with condition through addition or removal certain...
Prolonged blockade of AMPA-type glutamate receptors in hippocampal neuron cultures leads to homeostatic enhancements pre- and postsynaptic function that appear correlated at individual synapses, suggesting some form transsynaptic coordination. The respective modifications are important for overall synaptic strength but their interrelationship, dynamics, molecular underpinnings unclear. Here we demonstrate adaptation begins postsynaptically is ultimately communicated presynaptic terminals...
Ceftriaxone(Cef) selectively increases the expression of glial glutamate transporter-1 (GLT-1), which was thought to be neuroprotective in some circumstances. However, effect Cef on uptake GLT-1 mostly assayed using vitro studies such as primary neuron/astrocyte cultures or brain slices. In addition, neurons different ischemic models still discrepant. Therefore, this study undertaken observe global ischemia rats, and especially provide direct evidence up-regulation for contributing neuronal...
Background A pilot study has shown that real-time fMRI (rtfMRI) neurofeedback could be an alternative approach for chronic pain treatment. Considering the relative small sample of patients recruited and not strictly controlled condition, it is desirable to perform a replication as well double-blinded randomized with different control condition in patients. Here we conducted rtfMRI subgroup – postherpetic neuralgia (PHN) used sham control. We explored feasibility self-regulation rostral...
Z-Ligustilide (Z-LIG) is a major component in Rhizoma Chuanxiong, which has been traditionally used as health food supplement for the prevention of cerebrovascular disease China. This study investigates ability intranasal Z-LIG pretreatment to enhance protection against neuronal damage rats with middle cerebral artery occlusion (MCAO) and role cellular stress response mechanisms Nrf2 HSP70. significantly mitigated infarct volume, neurological dysfunction, blood-brain barrier disruption,...
Alzheimer's disease (AD) is characterized by progressive impairment of learning, memory, and cognitive deficits. Glutamate the major excitatory neurotransmitter in central nervous system plays an important role cognition. The homeostasis reutilization glutamate are dependent on astrocytic uptake transporter-1 (GLT-1) subsequent glutamate-glutamine cycle. Increasing evidence showed impairments GLT-1 expression activity cycle AD. Ceftriaxone (Cef) has been reported to upregulate GLT-1....
Abstract Severe acute hypoxic stress is a major contributor to the pathology of human diseases, including ischemic disorders. Current treatments focus on managing consequences hypoxia, with few addressing cellular adaptation low-oxygen environments. Here, we investigate whether accelerating hypoxia could provide strategy alleviate stress. We develop high-content phenotypic screening platform identify compounds that fast-track Our captures high-dimensional response trajectory consisting...
Abstract Glutamate toxicity causes neuronal death in neurodegenerative diseases; hence, there is a need for therapeutic agents rendering functional neuroprotection. We tested the effects of 17β‐estradiol (estrogen) rat primary cortical neurons after glutamate exposure. Wright staining and ApopTag assays indicated that 0.5 μM 24 hr caused apoptosis. Glutamate‐induced apoptosis correlated with upregulation calpain, proapoptotic shift Bax:Bcl‐2 ratio, increased activation caspase‐3....
Prolonged AMPA-receptor blockade in hippocampal neuron cultures leads to both an increased expression of GluA1 postsynaptically and increase vesicle pool size turnover rate presynaptically, adaptive changes that extend beyond simple synaptic scaling. As a molecular correlate, the β Ca 2+ /CaM-dependent kinase type II (βCaMKII) is response inactivity. Here we set out clarify role βCaMKII various manifestations adaptation. Knockdown by lentiviral-mediated shRNA prevented inactivity-induced...
Precise wiring of cortical circuits during development depends upon axon extension, guidance, and branching to appropriate targets. Motile growth cones at tips navigate through the nervous system by responding molecular cues, which modulate signaling pathways within axonal cones. Intracellular calcium has emerged as a major transducer guidance cues but exactly how modify actin microtubule cytoskeleton evoke cone behaviors is still mysterious. Axons must often pause their extension in tracts...