A5012304538- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Exercise and Physiological Responses
- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- Animal Disease Management and Epidemiology
- Autophagy in Disease and Therapy
- Genetic Neurodegenerative Diseases
- Viral Infections and Immunology Research
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Vector-Borne Animal Diseases
- Muscle activation and electromyography studies
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Amyotrophic Lateral Sclerosis Research
- Nutrition and Health in Aging
- Viral Infections and Vectors
- Medical Research and Treatments
- Educational Reforms and Innovations
- RNA Research and Splicing
- RNA modifications and cancer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hereditary Neurological Disorders
Nantong University
2016-2025
Chinese Academy of Agricultural Sciences
2021-2025
Lanzhou University
2023-2025
Lanzhou Veterinary Research Institute
2021-2025
Ministry of Education of the People's Republic of China
2023-2024
Sichuan University
2024
Chengde Medical University
2024
Anhui and Huaihe River Institute of Hydraulic Research
2023
Affiliated Hospital of Nantong University
2023
China Agricultural University
2022
Skeletal muscle atrophy occurs under various conditions, such as disuse, denervation, fasting, aging, and diseases. Although the underlying molecular mechanisms are still not fully understood, skeletal is closely associated with reactive oxygen species (ROS) overproduction. In this study, we aimed to investigate involvement of ROS in from perspective gene regulation, further examine therapeutic effects antioxidants on atrophy. Microarray data showed that expression many positive regulators...
Denervation induces skeletal muscle atrophy, accompanied by complex biochemical and physiological changes, with potentially devastating outcomes even an increased mortality. Currently, however, there remains a paucity of effective strategies to treat atrophy. Therefore, it is required understand the molecular mechanisms atrophy formulate new treatment strategies. In this study, we investigated transcriptional profile denervated after peripheral nerve injury in rats. The cDNA microarray...
The molecular mechanisms underlying denervated skeletal muscle atrophy with concomitant mass loss have not been fully elucidated. Therefore, this study aimed to attain a deeper understanding of the as critical step developing targeted therapy and retarding mass.We employed microarray analysis reveal potential atrophy. We used in vitro vivo models explore roles interleukin 6 (IL-6), Janus kinase (JAK), signal transducers activators transcription 3 (STAT3) atrophy.In study, differentially...
Nerve regeneration in adult mammalian spinal cord is poor because of the lack intrinsic neurons and extrinsic factors - glial scar triggered by injury inhibits or promotes regeneration. Recent technological advances spatial transcriptomics (ST) provide a unique opportunity to decipher most genes systematically throughout formation, which remains poorly understood. Here, we first constructed tissue-wide gene expression patterns mouse cords over course formation using ST after from 32 samples....
Aim: Diabetic sarcopenia leads to disability and seriously affects the quality of life. Currently, there are no effective therapeutic strategies for diabetic sarcopenia. Our previous studies have shown that inflammation plays a critical role in skeletal muscle atrophy. Interestingly, connection between chronic complications has been revealed. However, effects non-steroidal anti-inflammatory drug celecoxib on remains unclear. Materials Methods: The streptozotocin (streptozotocin)-induced...
Although denervated muscle atrophy is common, the underlying molecular mechanism remains unelucidated. We have previously found that oxidative stress and inflammatory response may be early events trigger atrophy. Isoquercitrin a biologically active flavonoid with antioxidative anti-inflammatory properties. The present study investigated effect of isoquercitrin on its possible mechanisms. was effective in alleviating mass loss following denervation dose-dependent manner. demonstrated optimal...
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress inflammation are two main molecular mechanisms involved in atrophy. In the current study, we want to explore whether how salidroside, with antioxidant anti-inflammatory properties, protects against skeletal induced by denervation. First, oxidative inflammatory response were examined during myotube nutrition deprivation. The results demonstrated cultured myotubes suffered from...
Skeletal muscle atrophy involves and requires widespread changes in skeletal gene expression signaling pathway, resulting excessive loss of mass strength, which is associated with poor prognosis the decline life quality several diseases. However, treatment remains an unresolved challenge to this day. The aim present study was investigate influence pyrroloquinoline quinone (PQQ), a redox-active o-quinone found various foods mammalian tissues, on atrophy, explore underlying molecular...
The regulation of apple (Malus domestica) fruit texture during ripening is complex and a fundamental determinant its commercial quality. In climacteric fruit, ripening-related processes are regulated by ethylene (ET), jasmonate (JA) also involved in the biosynthesis pathway, mainly through transcription factor MYC2. However, molecular genetic mechanism for between JA ET signaling pathways still needs to be elucidated. order explore how regulates ERF4, we used 'Gala' 'Ralls Janet' at...
Abstract Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial functions in movement and metabolism. In response to external stimuli injuries, range stem/progenitor cells, with stem cells or satellite (MuSCs) being the predominant cell type, are rapidly activated repair regenerate skeletal within weeks. Under normal conditions, MuSCs remain quiescent state, but become proliferative differentiate into new injury. addition MuSCs, some interstitial...
Abstract Skeletal muscle can undergo detrimental changes in various diseases, leading to dysfunction and atrophy, thus severely affecting people's lives. Along with exercise, there is a growing interest the potential of nutritional support against atrophy. This review provides brief overview molecular mechanisms driving skeletal atrophy summarizes recent advances interventions for preventing treating The supplements include amino acids their derivatives (such as leucine, β‐hydroxy,...
Skeletal muscle atrophy is associated with pro-inflammatory cytokines. Salidroside a biologically active ingredient of Rhodiola rosea, which exhibits anti-inflammatory property. However, there little known about the effect salidroside on denervation-induced atrophy. Therefore, present study aimed to determine whether could protect against and clarify potential molecular mechanisms. Denervation caused progressive accumulation inflammatory factors in skeletal muscle, especially interleukin 6...
Oxidative stress has been recognized to play a crucial role in the pathogenesis of peripheral nerve injury. Isoquercitrin (quercetin-3-glucoside) is flavonoid that exhibited many biological activities, including anti-oxidative effect. However, it unclear whether isoquercitrin protective effects on injury.Mice treated by were used as case group, and mice injected with saline was control group. Sciatic behavioral function assessed using SFI CMAPs measured electrophysiology. Schwann cells...
Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found oxidative stress and inflammation play an important role in the process of denervated atrophy. Extracellular vesicles derived from skin precursor-derived Schwann cells (SKP-SC-EVs) contain large amount antioxidants anti-inflammatory factors. This study explored whether SKP-SC-EVs alleviate by inhibiting inflammation. In vitro can be internalized caught myoblasts to promote...