A5051086315- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Liver Diseases and Immunity
- Muscle Physiology and Disorders
- Endoplasmic Reticulum Stress and Disease
- Drug Transport and Resistance Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Hedgehog Signaling Pathway Studies
- Heavy Metal Exposure and Toxicity
- Telomeres, Telomerase, and Senescence
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Aldose Reductase and Taurine
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Natural product bioactivities and synthesis
- Pesticide Exposure and Toxicity
- Sunflower and Safflower Cultivation
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
Nanjing University of Chinese Medicine
2014-2025
Nantong University
2019-2024
Second Affiliated Hospital of Nantong University
2024
Affiliated Hospital of Nantong University
2019-2024
Louisiana State University Health Sciences Center New Orleans
2022
Nanjing Drum Tower Hospital
2017-2022
Academy of Military Medical Sciences
2009-2015
Jiamusi University
2009-2015
Shenyang Pharmaceutical University
2009
Abstract Hepatic fibrosis is concomitant with sinusoidal pathological angiogenesis, which has been highlighted as novel therapeutic targets for the treatment of chronic liver disease. Our prior studies have demonstrated that curcumin potent antifibrotic activity, but mechanisms remain to be elucidated. The current work ameliorated fibrotic injury and angiogenesis in rat caused by carbon tetrachloride. Curcumin reduced expression a number angiogenic markers liver. Experiments vitro showed...
Abstract Activation of quiescent hepatic stellate cells (HSCs) is the major event in fibrogenesis, along with enhancement cell proliferation and overproduction extracellular matrix. Although inhibition induction apoptosis are potential strategies to block activation HSCs, a better understanding senescence activated HSCs can provide new therapeutic strategy for prevention treatment liver fibrosis. The antioxidant curcumin, phytochemical from turmeric, has been shown suppress HSC vitro vivo ....
It has emerged that hepatocyte necroptosis plays a critical role in chronic alcoholic liver disease (ALD). Our previous study identified the beneficial therapeutic effect of curcumin on alcohol-caused injury might be attributed to activation nuclear factor (erythroid-derived 2)-like 2 (Nrf2), whereas regulating and underlying mechanism remain determined. We first found alcohol consumption triggered obvious necroptosis, leading increased expression receptor-interacting protein 1, 3,...
Abstract Objectives In recent years, cellular senescence has attracted a lot of interest in researchers due to its involvement non‐alcoholic fatty liver disease (NAFLD). However, the mechanism is not clear. The purpose this study was investigate effect curcumol on hepatocyte NAFLD and molecular mechanisms implicated. Materials methods LVG Golden Syrian hamsters, C57BL/6J mice human cell line LO2 were used. Cellular assessed by analyses marker SA‐β‐gal, p16 p21, H3K9me3, γ‐H2AX telomerase...
Aim: Diabetic sarcopenia leads to disability and seriously affects the quality of life. Currently, there are no effective therapeutic strategies for diabetic sarcopenia. Our previous studies have shown that inflammation plays a critical role in skeletal muscle atrophy. Interestingly, connection between chronic complications has been revealed. However, effects non-steroidal anti-inflammatory drug celecoxib on remains unclear. Materials Methods: The streptozotocin (streptozotocin)-induced...
Abstract Alcoholic liver disease (ALD) is a common health problem worldwide, characterized by aberrant accumulation of lipid in hepatocytes. Inhibition has been well recognized as promising strategy for ALD. Previous studies showed that curcumin potential effect on ALD regulating oxidative stress and ethanol metabolism. However, the effects its mechanism remain unclear. Recent researches have indicated farnesoid X receptor (FXR) nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) excellent...
Abstract Hepatic fibrosis is concomitant with liver inflammation, which has been highlighted as significant treatment of chronic disease. We previously demonstrated that tetramethylpyrazine (TMP), the effective component Ligusticum chuanxiong Hort, can inhibit activation HSCs and consequential anti‐hepatic fibrosis. In this study, our work TMP improved histological architecture, decreased hepatic enzyme levels attenuated collagen deposition in rat fibrotic liver. addition, significantly...
Recent studies indicated that hepatocyte senescence plays an important role in the development of alcoholic fatty liver disease (AFLD), suggesting inhibition might be a potential strategy for AFLD treatment. The present study investigated effect curcumol, component from root Rhizoma Curcumae, on and underlying mechanisms implicated. results showed curcumol was able to reduce lipid deposition injury livers ethanol liquid diet-fed mice ethanol-treated LO2 cells. Both vivo vitro supplementation...
Abstract Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial functions in movement and metabolism. In response to external stimuli injuries, range stem/progenitor cells, with stem cells or satellite (MuSCs) being the predominant cell type, are rapidly activated repair regenerate skeletal within weeks. Under normal conditions, MuSCs remain quiescent state, but become proliferative differentiate into new injury. addition MuSCs, some interstitial...
Inflammatory bowel disease (IBD) is a multisystem condition that could affect the cutaneous systems, namely extraintestinal manifestations (EIMs). It has been suggested IBD associated with erythema nodosum (EN), malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, potential causal relationship between mentioned above EIMs still unclear. This study aims to determine effect of on EN, MM NMSC within Mendelian randomization (MR) design. Summary-level data for IBD, MM, were...
As a frequent event following chronic insult, liver fibrosis triggers wound healing reactions, with extracellular matrix components accumulated in the liver. During fibrogenesis, activation of hepatic stellate cells (HSCs) is pivotal event. Fibrosis regression can feasibly be treated through pharmacological induction HSC apoptosis. Herein we showed that dihydroartemisinin (DHA) improved histological architecture, decreased enzyme levels, and inhibited HSCs fibrotic rat DHA also induced...
Hepatic steatosis is the most distinctive feature of alcoholic liver disease (ALD). Our previous in vivo study showed that ligustrazine, a major active alkaloid isolated from Ligusticum chuanxiong Hort, attenuated alcohol-induced hepatic and vitro revealed nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation might be prerequisite. This was aimed to explore function Nrf2 protective effect ligustrazine illustrate downstream mechanisms. shRNA lentivirus introduced establish...
Portal hypertension is a frequent pathological symptom occurring especially in hepatic fibrosis and cirrhosis. Current paradigms indicate that inhibition of stellate cell (HSC) activation contraction anticipated to be an attractive therapeutic strategy, because activated HSC dominantly facilitates increase intrahepatic vein pressure through secreting extracellular matrix contracting. Our previous vitro study indicated dihydroartemisinin (DHA) inhibited contractility cultured by activating...