A5101824903- Aquaculture Nutrition and Growth
- Liver Disease Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Alcohol Consumption and Health Effects
- Aquatic life and conservation
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Antioxidant Activity and Oxidative Stress
- Machine Learning in Healthcare
- Photodynamic Therapy Research Studies
- Topological Materials and Phenomena
- Drug Solubulity and Delivery Systems
- Calpain Protease Function and Regulation
- Blood groups and transfusion
- Superconductivity in MgB2 and Alloys
- Pancreatic function and diabetes
- Heusler alloys: electronic and magnetic properties
China Pharmaceutical University
2021-2024
Nanjing Forestry University
2023-2024
University of Washington
2024
Ocean University of China
2020-2023
Ministry of Agriculture and Rural Affairs
2020-2023
Changshu No.1 People's Hospital
2023
Nantong University
2023
Henan University of Science and Technology
2023
Qingdao National Laboratory for Marine Science and Technology
2022
Sichuan Normal University
2021-2022
It has emerged that hepatocyte necroptosis plays a critical role in chronic alcoholic liver disease (ALD). Our previous study identified the beneficial therapeutic effect of curcumin on alcohol-caused injury might be attributed to activation nuclear factor (erythroid-derived 2)-like 2 (Nrf2), whereas regulating and underlying mechanism remain determined. We first found alcohol consumption triggered obvious necroptosis, leading increased expression receptor-interacting protein 1, 3,...
Abstract Alcoholic liver disease (ALD) is a common health problem worldwide, characterized by aberrant accumulation of lipid in hepatocytes. Inhibition has been well recognized as promising strategy for ALD. Previous studies showed that curcumin potential effect on ALD regulating oxidative stress and ethanol metabolism. However, the effects its mechanism remain unclear. Recent researches have indicated farnesoid X receptor (FXR) nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) excellent...
Hepatic steatosis is the most distinctive feature of alcoholic liver disease (ALD). Our previous in vivo study showed that ligustrazine, a major active alkaloid isolated from Ligusticum chuanxiong Hort, attenuated alcohol-induced hepatic and vitro revealed nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation might be prerequisite. This was aimed to explore function Nrf2 protective effect ligustrazine illustrate downstream mechanisms. shRNA lentivirus introduced establish...
Portal hypertension is a frequent pathological symptom occurring especially in hepatic fibrosis and cirrhosis. Current paradigms indicate that inhibition of stellate cell (HSC) activation contraction anticipated to be an attractive therapeutic strategy, because activated HSC dominantly facilitates increase intrahepatic vein pressure through secreting extracellular matrix contracting. Our previous vitro study indicated dihydroartemisinin (DHA) inhibited contractility cultured by activating...
A 30-day feeding experiment was conducted to investigate effects of dietary allicin on survival, growth, antioxidant capacity, innate immunity and expression inflammatory appetite related genes in large yellow croaker larvae. Four iso-nitrogenous (53% crude protein) iso-lipidic (19% lipid) diets were formulated via supplementing graded levels (0.0% (the control), 0.005%, 0.01% 0.02% dry diet, respectively). Results showed that, among treatments, larvae fed the diet with 0.005% had highest...
Integrating self-healing capabilities into epidermal electrodes is crucial to improving their reliability and longevity. Self-healing nanofibrous materials are considered an ideal candidate for constructing ultrathin, long-lasting wearable due lightweight high breathability. However, the strong interaction between fibers, nanofiber membranes cannot exist stably. Therefore, development of breathable still remains a major challenge. Here, hierarchical confinement strategy that combines...
Abstract Hepatic stellate cells (HSCs) are universally acknowledged to play a stimulative role in the pathogenesis of hepatic fibrosis and portal hypertension. HSCs when activated response liver injury characterized with many changes, HSC contraction being most common cause Previous studies have shown that dihydroartemisinine (DHA) is potential antifibrotic natural product by inducing apoptosis, whereas DHA regulating mechanisms involved remain riddle. Recent emphasized on importance...
Abstract A 30-d feeding trial was conducted to investigate effects of dietary eucommia ulmoides leaf extract (ELE) on growth performance, activities digestive enzymes, antioxidant capacity, immunity, expression inflammatory factors and feeding-related genes large yellow croaker larvae. Five micro-diets were formulated with supplementation 0 g kg −1 (the control), 5 (0·5 %), 10 (1·0 %) 20 (2·0 ELE, respectively. Results showed that the best performance found in larvae fed diet 1·0 % ELE....
Abstract Dietary l -carnitine (LC) is a nutritional factor that reduces liver lipid content. However, whether dietary LC can improve metabolism via simultaneous activation of mitochondrial fatty acid (FA) β -oxidation and suppression endoplasmic reticulum (ER) stress still unknown. Large yellow croaker were fed with high-fat diet (HFD) supplemented at 0, 1·2 or 2·4 ‰ for 10 weeks. The results indicated HFD reduced the total TAG content improved serum profiles. supplementation administered to...
A 30-day feeding trial was designed to investigate the physical properties of chitosan-coated microdiet (CCD) and effect CCD on survival, growth performance, activities digestive enzymes, intestinal development, antioxidant capacity, inflammatory response large yellow croaker larvae (initial weight: 3.81 ± 0.20 mg). Four isonitrogenous (50% crude protein) isolipidic (20% lipid) microdiets were prepared with different concentrations chitosan wall material by spray drying method (0.00%, 0.30%,...
A 30-day feeding experiment was operated to evaluate the impact of astaxanthin (Ast) on growth performance, activities digestive enzymes, antioxidant responses and lipid metabolism large yellow croaker (Larimichthys crocea) larvae. Four micro-diets (isonitrogenous isolipidic) were formulated with graded Ast levels (0, 20, 40 80 mg/kg) in form Haematococcus pluvialis powder 0.4, 0.8 1.6 g/kg). Results showed that specific rate larvae significantly enhanced by supplementation mg/kg compared...
Abstract The nutritional status experienced in the early development of life plays a vital role long-term metabolic state individual, which is known as programming. present study investigated effects vegetable oil (VO) programming during large yellow croaker. First, larvae were fed either fish (FO) diet or VO for 30 d. Subsequently, under same conditions, all commercial 90 d and thereafter challenged with an FO results showed that growth performance was significantly lower than those...
Abstract Design and fabrication of pH‐responsive nanofibrous membranes by biomaterials is a key step for drug delivery systems. Currently, there an increasing attention on design biocompatible Here, bio‐based loaded with antibiotic were fabricated the controlled release tetracycline hydrochloride (TH). The in vitro behavior varied different mass ratios poly (lactic acid) (PLA) cellulose acetate phthalate (CAP) was investigated to clarify mechanism. TH initial burst within 20 mins large than...