A5100397197- Muscle Physiology and Disorders
- Genomics and Phylogenetic Studies
- Natural product bioactivities and synthesis
- Plant-Microbe Interactions and Immunity
- Microbial Community Ecology and Physiology
- Neurogenetic and Muscular Disorders Research
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Ubiquitin and proteasome pathways
- Protein Hydrolysis and Bioactive Peptides
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- Pharmacological Effects of Natural Compounds
- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Plant Molecular Biology Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- Metabolomics and Mass Spectrometry Studies
Nantong University
2022-2025
Sichuan University
2023-2025
Wuhan Business University
2025
Wuhan University
2023-2025
State Key Laboratory of Biotherapy
2025
First Affiliated Hospital of Zhengzhou University
2025
Queen Mary University of London
2021-2024
Southern Medical University
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Northeast Agricultural University
2008-2024
Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed CKI can inhibit the proliferation hepatocellular carcinoma (HCC) cell lines, active compounds, potential targets and pathways involved these effects not systematically investigated. Here, we proposed novel idea "main compound-based network pharmacology" explore anti-cancer mechanism CKI. Our...
Growing evidence shows that Baihu-Guizhi decoction (BHGZD), a traditional Chinese medicine (TCM)-originated disease-modifying anti-rheumatic prescription, may exert satisfying clinical efficacy for rheumatoid arthritis (RA) therapy. In our previous studies, we verified its immunomodulatory and anti-inflammatory activities. However, bioactive compounds (BACs) of BHGZD the underlying mechanisms remain unclear. Herein, an integrative research strategy combining UFLC-Q-TOF-MS/MS, gene expression...
As climate change events become more frequent, drought is an increasing threat to agricultural production and food security. Crop rhizosphere microbiome root exudates are critical regulators for adaptation, yet our understanding on the bacterial communities exudate composition as affected by stress far from complete. In this study, we performed 16S rRNA gene amplicon sequencing widely targeted metabolomic analysis of soil two contrasting rice genotypes (Nipponbare Luodao 998) exposed...
Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However, the underlying mechanisms remain obscure. Here we report that self-renewing hnPSCs spontaneously and efficiently give rise three dimensional (3D) suspension culture. The spontaneous mimic early stage human in terms structure, size, transcriptome characteristics are capable progressing post-implantation stages. This property is conferred by...
Anemoside B4 (AB4), a triterpenoidal saponin from Pulsatilla chinensis, shows significant anti-inflammatory activity, and may be used for treating inflammatory bowel disease (IBD). Nevertheless, its application is limited due to high molecular weight pronounced water solubility. To discover new effective agents IBD, we synthesized 28 AB4 derivatives evaluated their cytotoxic activities in vitro. Among them, A3–6 exhibited significantly superior activity compared AB4. It showed improvement...
Abstract Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA CRC cells was little reported. Here, we proved that elicited cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, treatment induced autophagy via inhibiting AKT-MTOR signaling pathway. Inhibition by either administration autophagic inhibitor chloroquine or siRNA-mediated knockdown ATG5 could augment BA-induced apoptotic cell death as well...
Osteoporosis (OP) is a highly prevalent orthopedic condition in postmenopausal women and the elderly. Currently, OP treatments mainly include bisphosphonates, receptor activator of nuclear factor kappa-B ligand (RANKL) antibody therapy, selective estrogen modulators, teriparatide (PTH1-34), menopausal hormone therapy. However, increasing evidence has indicated these may exert serious side effects. In recent years, Traditional Chinese Medicine (TCM) become popular for treating disorders....
Nature-derived anti-allergic peptides are considered one of the promising therapeutic approaches in alleviating food allergy. The present focus aims to open up a new high-value and full-use way for processing industrial fish wastes while expecting obtain peptides. In this research, peptide from Atlantic Salmon (Salmo salar) byproduct hydrolysate by pepsin hydrolysis, was purified identified using consecutive chromatographic techniques such as Sephadex G-15 gel permeation chromatography, high...
Abstract Abnormal angiogenesis occurs during the growth of solid tumors resulting in increased vascular permeability to fluids and metastatic cancer cells. Anti-angiogenesis therapy for is effective treatment patients. However, efficacy anti-angiogenesis limited by drug resistance. The findings current study showed that HIF1α R282 methylated PRMT3, which necessary its stabilization oncogene function. Analysis PRMT3-mediated tumorigenesis methylation-dependent. A novel therapeutic molecule...