A5056038209- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Polymer Foaming and Composites
- Pancreatic function and diabetes
- Advanced Antenna and Metasurface Technologies
- biodegradable polymer synthesis and properties
- Electromagnetic wave absorption materials
- Carbon dioxide utilization in catalysis
- Tissue Engineering and Regenerative Medicine
- Renal and related cancers
- Metamaterials and Metasurfaces Applications
- Single-cell and spatial transcriptomics
- Polymer composites and self-healing
- Building Energy and Comfort Optimization
- Plant Stress Responses and Tolerance
- Conducting polymers and applications
- Integrated Energy Systems Optimization
- Thin-Film Transistor Technologies
- Dyeing and Modifying Textile Fibers
- Crop Yield and Soil Fertility
- Plant responses to elevated CO2
- Tribology and Wear Analysis
- Biochemical effects in animals
- Synthesis and properties of polymers
China Agricultural University
2024
Guangzhou Experimental Station
2023-2024
Guangzhou Medical University
2024
Xinjiang Institute of Ecology and Geography
2024
Xinjiang Academy of Agricultural Sciences
2024
China State Shipbuilding (China)
2024
Kunming University of Science and Technology
2021-2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
Shanghai Jiao Tong University
2022
Anhui University of Science and Technology
2021
Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However, the underlying mechanisms remain obscure. Here we report that self-renewing hnPSCs spontaneously and efficiently give rise three dimensional (3D) suspension culture. The spontaneous mimic early stage human in terms structure, size, transcriptome characteristics are capable progressing post-implantation stages. This property is conferred by...
Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) provide promising therapies for type 1 diabetes. Current PP differentiation requires a high amount of Activin A during the definitive endoderm (DE) stage, making it economically difficult commercial ventures. Here we identify dose-dependent role Wnt signaling in controlling DE without A. While high-level activation induces mesodermal formation, low-level by small-molecule inhibitor glycogen synthase kinase 3 is...
ABSTRACT Specific pore structure is a vital essential for scaffolds applied in tissue engineering. In this article, poly(lactide‐ co ‐glycolide) (PLGA) with bimodal including macropores and micropores to facilitate nutrient transfer cell adhesion were fabricated by combining supercritical CO 2 (scCO ) foaming particle leaching technique. Three kinds of NaCl particles different scales (i.e., 100–250, <75, <10 μm) used as porogens, respectively. particular, heterogeneous nucleation...
Genetically encoded calcium indicator (GCaMP) proteins have been reported for imaging cardiac cell activity based on intracellular transients. To bring human pluripotent stem (hPSC)-derived cardiomyocytes (CMs) to the clinic, it is critical evaluate functionality of CMs. Here, we show that GCaMP6s-expressing hPSCs can be generated and used CM characterization. By leveraging CRISPR-Cas9 genome editing tools, a knockin line constitutively expresses GCaMP6s, an ultrasensitive sensor protein. We...
Agroforestry intercropping is an effective way to optimize land use and ensure food security. However, the physiological mechanism by which shading of dominant plants inhibits yield non-dominant in this mode remains be investigated. A two-year location experiment walnut-winter wheat intercrop combined with exogenous 6-benzyladenine (6-BA, first synthetic cytokinin) treatment was conducted reveal 6-BA inhibiting growth formation under shade stress measuring photosynthetic characteristics,...
A robust Stille gem-difluoroallylation of arylstannanes with 3-bromo-3,3-difluoropropenes has been established. The catalyst was found to exert critical effect on the reaction chemoselectivity. By using Pd(OH)2/C as catalyst, a series 3-(hetero)aryl/vinyl-3,3-difluoropropenes were obtained in high efficiency α-substitution regioselectivity. broad substrate scope, and various substitution patterns well tolerated both substrates. Notably, can be easily extended late-stage many bioactive molecules good
In a district cooling system (DCS), the distribution (i.e., water or chilled system) will continue to be critical consideration because it substantially contributes total energy consumption. Thus, in this paper, new distributed variable-frequency pump (DVFP) with storage (WS) for is adapted DCS large end-use load fluctuations. The basic principle and saving potential of analyzed. A case study conventional central circulating (CCCP) presented compare consumption operating performance CCCP...
Abstract A two‐step grafting procedure has been used to graft tetraethylenepentamine (TEPA) and nano silicon dioxide (SiO 2 ), onto graphene oxide (GO) surface. The resulting modified GO, that was TGOS, which as a reinforcement in thermoplastic polyurethanes (TPUs). Mechanical properties, thermal stability rheological properties of composites were investigated. Results showed the addition TGOS significantly improved mechanical TPU compared with pure sample. Tensile strength elongation at...
This study prepared 4,4-diaminodiphenylmethane (DDM)-functionalized graphene oxide (GO)@silica dioxide (SiO2) nano-composites through amidation reaction and low-temperature precipitation. The resulting modified GO, that was DDM−GO@SiO2. found DDM−GO@SiO2 showed good dispersion compatibility with thermoplastic polyurethane (TPU) substrates. Compared pure TPU, the tensile strength of TPU composites increased by 41% to 94.6 MPa at only 0.5 wt% In addition, even when a small amount added, UV...
Summary Embryo models open exciting opportunities for improving our understanding of development and advancing medicine. However, current depend on intricate procedures the integration separately generated cell types. Here, we aimed to establish a chemical-only strategy induce cellular plasticity generate embryo founder-like cells. Within 60 hours, chemical-induced pluripotent stem cells activated early lineage specifiers, Cdx2 Gata6 , while maintaining Oct4/ Pou5f1 expression. Following...
Using 4-mercaptomethyl-3, 6-dithio-1,8-octyl dithiol and divinylbenzene as raw materials 2-hydroxy-2-methylphenylacetone photoinitiator, the results showed that polymers had excellent optical properties. Among them, when functional group molar ratio of thiol to double bond was 3:5, polymer film transmittance 94%, refractive index reached 1.613. In terms adhesive application, cured achieved an strength 0.9 MPa on polar glass, thus it can be considered for use adhesive. addition, monomer...
Abstract Using Pentaerythritol tetra (3-mercapto propionate) as primary thiol and butylate) secondary thiol, the effect of structure on properties thiol-ene system were investigated. The results show that for triallyl isocyanurate system, had little glass transition temperature, but tri (1, 2-propylene glycol) diacrylate divinylbenzene systems showed a higher temperature. In terms optical anti-swelling, better performance.
Human pluripotent stem cells (hPSCs)-derived pancreatic progenitors (PPs) provide promising cell therapies for Type I Diabetes (T1D). Current PP differentiation requires high amount of Activin A during definitive endoderm (DE) stage, making it economically difficult commercial ventures. Here we identify a dose-dependent role Wnt signaling in controlling DE without A. While high-level activation induces mesodermal formation, low-level by small-molecule inhibitor glycogen synthase kinase...