A5013835655- Reproductive Biology and Fertility
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Renal and related cancers
Yunnan University
2023-2024
Wuhan Children's Hospital
2024
Huazhong University of Science and Technology
2024
Center for Life Sciences
2024
Soochow University
2021
Mouse zygotes undergo multiple rounds of cell division, resulting in the formation preimplantation blastocysts comprising three lineages: trophectoderm (TE), epiblast (EPI), and primitive endoderm (PrE). Cell fate determination plays a crucial role establishing healthy pregnancy. The initial separation lineages gives rise to TE inner mass (ICM), from which trophoblast stem cells (TSC) embryonic (ESC) can be derived vitro. Studying lineage differentiation is greatly facilitated by clear...
<p indent="0mm">Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development. Deoxyguanosine kinase (DGUOK) is nucleoside that salvages purine nucleosides mitochondria critical for mitochondrial DNA replication non-proliferating cells. <italic> Dguok</italic> loss-of-function mutations deletions lead to hepatocerebral deletion syndrome. However, its potential reproduction remains largely unknown. In this study, we find <italic>Dguok</italic> knockout results...
Summary Embryo models open exciting opportunities for improving our understanding of development and advancing medicine. However, current depend on intricate procedures the integration separately generated cell types. Here, we aimed to establish a chemical-only strategy induce cellular plasticity generate embryo founder-like cells. Within 60 hours, chemical-induced pluripotent stem cells activated early lineage specifiers, Cdx2 Gata6 , while maintaining Oct4/ Pou5f1 expression. Following...
Abstract Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development. Deoxyguanosine kinase (DGUOK) is nucleoside that salvages purine the mitochondria critical for mitochondrial DNA replication non-proliferating cells. Dguok loss-of-function mutations deletions lead to hepatocerebral deletion syndrome. However, its potential reproduction remains largely unknown. We found knockout results female infertility. Mechanistically, deficiency of DGUOK hinders...
Objective To study the genetic polymorphism of whole mitochondrial DNA （mtDNA） genomes in She population Zhejiang and to explore maternal structure population. Methods Whole mtDNA 231 unrelated individuals from Province were sequenced. The number mutations genetics parameters such as, haplotype diversity （HD）, discrimination power （DP）, random match probabilities （RMP） analyzed. haplogroups classified, relationships between nine other Chinese populations estimated. Results In samples, 8 507...