A5100638080- Congenital heart defects research
- Coral and Marine Ecosystems Studies
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Advanced Fiber Laser Technologies
- Zebrafish Biomedical Research Applications
- RNA modifications and cancer
- Blood Coagulation and Thrombosis Mechanisms
- Aquaculture disease management and microbiota
- Marine Sponges and Natural Products
- Protease and Inhibitor Mechanisms
- Developmental Biology and Gene Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Interference and Gene Delivery
- Photonic and Optical Devices
- Catalysis for Biomass Conversion
- Electric Motor Design and Analysis
- Hydrology and Watershed Management Studies
- Signaling Pathways in Disease
- Reproductive Biology and Fertility
- Genomic variations and chromosomal abnormalities
- Magnetic Bearings and Levitation Dynamics
- Pluripotent Stem Cells Research
- Pregnancy and preeclampsia studies
Chinese Academy of Sciences
2015-2025
South China Sea Institute Of Oceanology
2023-2025
Institute of Oceanology
2016-2025
Yunnan University
2012-2024
University of Chinese Academy of Sciences
2013-2024
Xinjiang Institute of Ecology and Geography
2024
Ningbo Institute of Industrial Technology
2023-2024
Guiyang Medical University
2024
Shanxi Medical University
2021-2023
Shaanxi Provincial People's Hospital
2021-2023
The eukaryotic translation initiation factor 5A (eIF-5A) is a highly conserved protein found in all organisms. Although originally identified as factor, recent studies mammalian and yeast (Saccharomyces cerevisiae) cells suggest that eIF-5A mainly involved RNA metabolism trafficking, thereby regulating cell proliferation, growth, programmed death. In higher plants, the physiological function of remains largely unknown. Here, we report identification characterization an Arabidopsis...
Vascular smooth muscle cell (VSMC) migration and proliferation are the hallmarks of restenosis pathogenesis after angioplasty. Cyclooxygenase (COX)-derived prostaglandin (PG) E₂ is implicated in vascular remodeling response to injury. However, its precise molecular role remains unknown.This study investigates impact COX-2-derived PGE₂ on neointima formation injury.Vascular was induced by wire injury femoral arteries mice. Both ratio were diminished COX-2 knockout mice as compared with...
Apolipoprotein CII is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia also important risk factor for development cardiovascular disease. Animal models to study are limited, no Apoc2 knockout mouse reported. To develop genetic model hypertriglyceridemia, we generated apoc2 mutant zebrafish characterized by...
Large numbers of maternal RNAs are deposited in oocytes and reserved for later development. Control RNA translation during oocyte maturation has been extensively investigated its regulatory mechanisms well documented. However, translational regulation early oogenesis is largely unexplored. In this study, we generated zebrafish zar1 mutants which result apoptosis fully penetrant male Loss p53 suppresses the restores immature ovaries show upregulation proteins implicated endoplasmic reticulum...
Abstract Background Retinal disorders cause substantial visual burden globally. Accurate estimates of the vision loss due to retinal diseases are pivotal inform optimal eye health care planning and allocation medical resources. The purpose this study is describe proportion impairment blindness caused by major in China. Methods A nationwide register-based vitreoretinal disease covering all 31 provinces (51 treating centres) mainland total 28 320 adults diagnosed with were included....
The syncytiotrophoblast layer is the most critical and prominent tissue in placenta. SynT cells are differentiated from trophoblast stem (TSCs) during early embryogenesis. Mouse TSCs can spontaneously differentiate into of mixed lineages vitro upon withdrawal stemness-maintaining factors. However, differentiation defined placental cell remains challenging. We report here that canonical Wnt signaling activation robustly induces expression SynT-II lineage-specific genes Gcm1 SynB suppresses...
Genome editing by the well-established CRISPR/Cas9 technology has greatly facilitated our understanding of many biological processes. However, a complete whole-genome knockout for any species or model organism rarely been achieved. Here, we performed systematic all genes (1333) on Chromosome 1 in zebrafish, successfully mutated 1029 genes, and generated 1039 germline-transmissible alleles corresponding to 636 genes. Meanwhile, high-throughput bioinformatics analysis, found that sequence...
Abstract We report on an Er:Y 2 O 3 ceramic channel waveguide laser operating at continuous-wave and passively Q-switched regimes, for the first time to best of our knowledge. The has been fabricated by a femtosecond direct-writing technique. maximum output power reached 123.5 mW in mode with slope efficiency about 21%, lasing behavior found simultaneously 2710.28, 2716.76, 2723.18 nm. have further MXene Ti C T x saturable absorber mirror operate regime. At same time, property characterized,...
Abstract Definitive hematopoiesis generates hematopoietic stem/progenitor cells (HSPCs) that give rise to all mature blood and immune cells, but remains poorly defined in human. Here, we resolve human populations at the earliest stage by single-cell RNA-seq. We characterize distinct molecular profiling between early primitive definitive both embryonic stem cell (hESC) differentiation development. identify CD44 specifically discriminate generate HSPCs from hESCs. The multipotency of...
The positive effects of exposing corals to microorganisms have been reported though how the benefits are conferred poorly understood. Here, we isolated an actinobacterial strain (SCSIO 13291) from Pocillopora damicornis with capabilities synthesize antioxidants, vitamins, and antibacterial antiviral compounds supported phenotypic and/or genomic evidence. Strain SCSIO 13291 was labeled 5 (and - 6)-carboxytetramethylrhodamine, succinimidyl ester cell suspension directly inoculated onto coral...
Abstract DNA methylation is a prevalent epigenetic modification in vertebrates, and it has been shown to be involved the regulation of gene expression embryo development. However, remains unclear how regulates sexual development, especially species without sex chromosomes. To determine this, we utilized zebrafish investigate reprogramming during juvenile germ cell development adult female-to-male transition. We reveal that primordial cells (PGCs) undergo significant methylome PGCs reset an...
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying agonistic relaxation of airway smooth muscle (ASM) not well defined. By exploring ASM bitter substances, we observed that pretreatment with substances nearly abolished methacholine (MCh)-induced increase in cell (ASMC) calcium concentration, thereby suppressing calcium-induced contraction...
Abstract 2,5‐Furandicarboxylic acid (FDCA) has emerged as an important bio‐based furanic compound, which broad application prospects in renewable energy and materials, especially the preparation of polyethylene 2,5‐furandicarboxylate (PEF). While conventional synthesis FDCA involves oxidation 5‐hydroxymethylfurfural (HMF) a substitute, thermal chemical instability HMF due to its aldehyde group poses challenges. A more favorable alternative is utilization 2,5‐bis(hydroxymethyl)furan (BHMF),...
The precise formation of three-dimensional motor circuits is essential for movement control. Within these circuits, motoneurons (MNs) are specified from spinal progenitors by dorsoventral signals and distinct transcriptional programs. Different MN subpopulations have stereotypic cell body positions show specific spatial axon trajectories. Our knowledge outgrowth remains incomplete. Here, we report a zebrafish gene-trap mutant, short lightning (slg), in which prdm14 expression disrupted. slg...
Coronary vessel development is a highly coordinated process during heart formation. Abnormal and dysfunction of the coronary network are contributory factors in majority disease. Understanding molecular mechanisms that regulate formation crucial for preventing treating We report zebrafish gene-trap vinculin b (vclb) mutant displays abnormal among multiple cardiac defects. The shows overproliferation epicardium-derived cells disorganization vessels, they eventually die off at juvenile stages....
In most vertebrates, fully grown oocytes are arrested in meiotic prophase I and only resume the cell cycle upon external stimuli, such as hormones. The proper arrest resumption of is critical for reproduction. A Galpha(S) signaling pathway essential conserved organisms from Xenopus to mouse human. previous gene association study implicated that mutations human ACSL6 may be related premature ovarian failure. However, functional roles infertility have yet reported. present study, we found...
Xenopus maternal Norrin, which activates Wnt signaling but inhibits TGF-β family molecules, is essential for neuroectoderm formation. Loss of inhibition in Norrin may contribute to the development Norrie disease.
To quantitatively evaluate the effects on water quality improvement caused by reducing external loadings entering Lake Erhai through inflow rivers, a one-dimensional hydrodynamic and ecological model (DYRESM–CAEDYM) was set up to simulate level variations. The calibrated validated used conduct six scenarios for evaluating responses different amounts of loading reduction at Erhai. results show (1) total nitrogen (TN) concentration will be higher than 0.5 mg/L without any watershed pollution...