A5103507002- Molecular Junctions and Nanostructures
- Advanced biosensing and bioanalysis techniques
- Retinal Development and Disorders
- Photonic and Optical Devices
- Supercapacitor Materials and Fabrication
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advancements in Battery Materials
- Nanowire Synthesis and Applications
- Advanced Photocatalysis Techniques
- Semiconductor materials and devices
- Gold and Silver Nanoparticles Synthesis and Applications
- Semiconductor Lasers and Optical Devices
- Graphene research and applications
- Photoreceptor and optogenetics research
- MicroRNA in disease regulation
- Quantum Dots Synthesis And Properties
- Analytical Chemistry and Sensors
- Gas Sensing Nanomaterials and Sensors
- Semiconductor Quantum Structures and Devices
- Advanced Chemical Sensor Technologies
- Cancer-related molecular mechanisms research
- Biosensors and Analytical Detection
- Electrocatalysts for Energy Conversion
- Chromatography in Natural Products
Chinese Academy of Sciences
2016-2025
Shanghai Jiao Tong University
2007-2025
East China University of Science and Technology
2019-2025
First Affiliated Hospital of Harbin Medical University
2024-2025
University of Science and Technology of China
2025
Changchun Institute of Optics, Fine Mechanics and Physics
2025
Hebei Agricultural University
2024
Hefei Institutes of Physical Science
2022-2024
Harbin Medical University
2024
Sichuan University
2020-2024
Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their needle-like shape high durability, concerns been raised that MWCNTs may induce asbestos-like pathogenicity. Although recent studies demonstrated various types reactivities, physicochemical features determine cytotoxicity carcinogenicity mesothelial cells remain unclear. Here, we showed deleterious effects nonfunctionalized on human were...
Abstract Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment and have been shown to contribute aggressiveness. However, detailed mechanisms underlying pro-metastatic effect TAMs on gastric cancer not clearly defined. Here, we show that enriched in cancer. characterized by M2-polarized phenotype promote migration cells vitro vivo. Furthermore, find M2-derived exosomes determine TAMs-mediated pro-migratory activity. Using mass spectrometry, identify...
Metal-free catalysts for oxygen reduction reaction (ORR) are the desired materials low-cost proton exchange membrane fuel cells. Graphdiyne (GDY), a novel type of two-dimensional carbon allotrope, is featured by its sp- and sp2-hybridized atoms, different from other existing materials. Thus, nitrogen (N) can be doped in new styles substituting sp-hybridized effective ORR, which has been displayed this study using both experimental theoretical technologies. The N-doped GDY was synthesized...
Uniform gold hollow nanospheres with tunable interior-cavity sizes were fabricated by using Co nanoparticles as sacrificial templates and varying the stoichiometric ratio of starting material HAuCl4 over reductants. The formation these nanostructures is attributed to two subsequent reduction reactions: initial nanoparticles, followed NaBH4. In addition, a thick layer silica was successfully coated onto nanospheres. These are extensively characterized TEM, XRD, HRTEM, SEM, electron...
Formation of unsymmetrical biaryls from simple arenes has been achieved successfully in a catalytic system Pd(OAc)2/CF3CO2H(TFA)/K2S2O8 just by tuning the concentrations and TFA under mild conditions. A proposed mechanism containing two-step aromatic C−H activation on this novel intermolecular cross-coupling is also suggested partly supported experiments.
Rab proteins are important regulators of insulin-stimulated GLUT4 translocation to the plasma membrane (PM), but precise steps in trafficking modulated by particular remain unclear. Here, we systematically investigate involvement trafficking, focusing on directly mediating storage vesicle (GSV) delivery PM. Using dual-color total internal reflection fluorescence (TIRF) microscopy and an insulin-responsive aminopeptidase (IRAP)-pHluorin fusion assay, demonstrated that Rab10 facilitated GSV...
With the end of Moore's law in sight, new computing architectures are urgently needed to satisfy increasing demands for big data processing. Neuromorphic with photoelectric learning capability good candidates energy-efficient recognition and classification tasks. In this work, artificial synapses based on ZnO1-x/AlOy heterojunction were fabricated plasticity was investigated. Versatile synaptic functions such as short-term/long-term plasticity, paired-pulse facilitation, neuromorphic...
The endohedral fullerene Sc3NC@C80-Ih has been synthesized and characterized; it an unprecedented planar quinary cluster in a cage. It is also the first chemical compound which presence of (NC)3− trianion disclosed. fascinating intramolecular dynamics enables whole molecule to display high polarity promising ferroelectricity. This finding inspires possibility that such may be useful constructing many other fullerenes.
This paper describes a molecular diode with high, statistically robust, rectification ratios R of 1.1 × 103. These diodes operate new mechanism charge transport based on sequential tunneling involving both the HOMO and HOMO–1 positioned asymmetrically inside junction. In addition, are stable withstand voltage cycling for 1500 times, yield in working junctions is 90%.
Hypoxia and acidity provide microenvironment for selection under evolutionary pressure proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present all life kingdoms, equilibrating the reactions among CO2, bicarbonate H+. CA9, membrane-associated α-CA, has been drug target various cancers. Whereas iron is essential not only cells but also lives on earth, little known association hypoxia, metabolism, extracellular redox regulation. Malignant...
Fatty acid synthase (FASN), the key metabolic enzyme of de novo lipogenesis, provides proliferative and metastatic capacity directly to cancer cells have been described. However, impact aberrant activation this lipogenic on host anti-tumor immune milieu remains unknown. In study, we depicted that elevated FASN expression presented in ovarian with more advanced clinical phenotype correlated immunosuppressive status, which characterized by lower number dysfunction infiltrating T cells....
Novel Zn3V2O8 hexagon nanosheets were synthesized by a simple hydrothermal method and characterized various spectroscopic techniques. The revealed to show high performance as an anode material for lithium-ion batteries with good rate capacity, cycling stability, excellent discharge capacity up 1103 mA h g−1 at 200 current density.
It was proposed in 1974 that molecules could rectify, but molecular diodes with simultaneously high rectification ratios, yields of working junctions, and reproducibility are rare, despite a huge body experimental work. Although every type junction contains certain distribution defects induced by the topography surface, roles these device performance rarely studied. We show control over bottom electrode self-assembled monolayer (SAM)-based junctions terms number grains, width grain...
Abstract Litter decomposition plays important roles in carbon and nutrient cycling. In dryland, both microbial abiotic degradation (by UV light or other forces) drive variation rates, but whether how litter traits position determine the balance between these processes is poorly understood. We investigated relationships quality their rates among diverse plant species a desert ecosystem vertically contrasting positions representing distinct environments driven by different relative...
Abstract Heterotypic interactions between tumor cells and macrophages can enable progression hold potential for the development of therapeutic interventions. However, communication tumors its mechanism are poorly understood. Here, we find that tumor‐associated (TAM) from tumor‐bearing mice have high amounts lipid as compared to tumor‐free mice. TAM also present content in clinical human gastric cancer patients. Functionally, with levels characterized by polarized M2‐like profiling, exhibit...
Alkali burn is a potentially blinding corneal injury. During the progression of alkali burn-induced injury, overwhelmed oxidative stress in cornea triggers cell damage, including changes cellular macromolecules and lipid peroxidation membranes, leading to impaired transparency, decreased vision, or even blindness. In this study, we identified that ferroptosis, type peroxidation-dependent death, mediated Ferroptosis-targeting therapy protected from damage neovascularization. However, specific...