A5000773364- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Photochromic and Fluorescence Chemistry
- Advanced Sensor and Energy Harvesting Materials
- RNA and protein synthesis mechanisms
- Advanced Fluorescence Microscopy Techniques
- Polymer composites and self-healing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Luminescence and Fluorescent Materials
- Advanced Drug Delivery Systems
- Corneal Surgery and Treatments
- Radical Photochemical Reactions
- Additive Manufacturing and 3D Printing Technologies
- RNA Research and Splicing
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Photoreceptor and optogenetics research
- Gastrointestinal motility and disorders
- Polydiacetylene-based materials and applications
- Photodynamic Therapy Research Studies
- Cellular Mechanics and Interactions
- Surgical Sutures and Adhesives
- Platelet Disorders and Treatments
- Hemostasis and retained surgical items
- Collagen: Extraction and Characterization
Shanghai Jiao Tong University
2021-2025
East China University of Science and Technology
2018-2023
The wet and highly dynamic environment of the mouth makes local treatment oral mucosal diseases challenging. To overcome this, a photo-crosslinking hydrogel adhesive is developed inspired by success light-curing techniques in dentistry. operates on fast (within 5 s) phototriggered S-nitrosylation coupling reaction employs imine anchoring to connect host tissues. Unlike other often-used clinical agents that adhere weakly for short durations, this thin, elastic, adhesive, degradable cyclic...
A new class of coumarin photocaging groups modified with an electron-rich styryl moiety at the 3-position was constructed. The large π-conjugated structure and stabilization carbocation intermediates by electron donors endowed excellent long-wavelength absorption, two-photon absorption cross-sections, high uncaging quantum yields. Moreover, displayed unique photobleaching properties after photocleavage as a result intramolecular cyclization rearrangement intermediate to form five-membered...
Hydrogels have long been used for encapsulating stem cell-derived conditioned mediums to achieve skin regeneration after wounding. However, inappropriate mechanical strength, low adhesion and elasticity limit their clinical application. To address these challenges, we engineered a hyaluronic acid-based hydrogel grafted with methacrylic anhydride N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butanamide (NB) groups encapsulate lyophilized amnion-derived medium (AM-CM). This...
Abstract Osteoporosis is a widespread condition that induces an inflammatory microenvironment, limiting the effectiveness of conventional therapies and presenting significant challenges for bone defect repair. To address these issues, high‐strength gelatin hydrogel scaffold loaded with roxadustat developed, specifically designed to remodel microenvironment enhance osteoporotic regeneration. By incorporating minimal methacrylated hyaluronic acid (HAMA) into o ‐nitrobenzyl functionalized...
Liquid-crystal elastomers (LCEs) capable of performing large and reversible deformation in response to an external stimulus are important class soft actuators. However, their manufacturing process typically involves a multistep approach that requires harsh conditions. For the very first time, LCEs with customized geometries can be manufactured by rapid one-step at room temperature developed. The hydrogen bond (H-bond) crosslinked main chain polymers comprising flexible short side chains....
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non‐specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery synthetic hydrogel material biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted at gastrointestinal (GI) tract. An ideal integration intestinal epithelium entails integrated...
Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular and sensing events. Here, we chemically evolved self-labeling SNAP-tag into a palette of mimics (SmFPs) that possess bright, rapidly inducible fluorescence ranging from cyan to infrared. SmFPs integral chemical-genetic entities based on same fluorogenic principle as FPs, i.e., induction non-emitting molecular rotors by conformational locking. We demonstrate usefulness these in real-time...
Considerable progress has been made in the development of drug delivery systems for diabetic wounds. However, underlying drawbacks, such as low efficiency and poor tissue permeability, have rarely addressed. In this study, a multifunctional biohybrid nanorobot platform comprising an artificial unit several biological components is constructed. The magnetically driven surface modified with antibacterial 2-hydroxypropyltrimethyl ammonium chloride chitosan, which enables entire to move...
Abstract A new class of coumarin photocaging groups modified with an electron‐rich styryl moiety at the 3‐position was constructed. The large π‐conjugated structure and stabilization carbocation intermediates by electron donors endowed excellent long‐wavelength absorption, two‐photon absorption cross‐sections, high uncaging quantum yields. Moreover, displayed unique photobleaching properties after photocleavage as a result intramolecular cyclization rearrangement intermediate to form...
The first instance of utilizing high viscosity as a stimulus to activate photocages for the precise control cargo photorelease.
Liquid crystal elastomers (LCEs) are versatile soft actuators known for their flexible texture, low density, and ability to undergo reversible deformations that mimic the behavior of skeletal muscles. These properties make them highly attractive applications in exoskeletons, robotics, medical devices. However, functionality is typically limited simple discontinuous deformations. This study introduces a novel structural design enables precise control both mode amplitude deformation....
Liquid crystal elastomers (LCEs) are versatile soft actuators known for their flexible texture, low density, and ability to undergo reversible deformations that mimic the behavior of skeletal muscles. These properties make them highly attractive applications in exoskeletons, robotics, medical devices. However, functionality is typically limited simple discontinuous deformations. This study introduces a novel structural design enables precise control both mode amplitude deformation....
Abstract Owing to the inherently gradual nature of coagulation, body fails in covalently crosslinking stabilize clots rapidly, even with aid topical hemostats, thus inducing hemostatic failure and potential rebleeding. Although recently developed adhesives confer sealing bleeding sites independently interfacial blood hampers their adhesion practical applications. Here, we report a reactive hemostat based on blood-imbibing -crosslinking microparticles. Once contacting blood, microparticles...
Abstract Soft actuators that mimic the softness and deformability of living organisms have great potential for use in various fields. For most soft actuators, achieving both reprogrammable shape high work capacity is crucial but challenging. These properties are mutually exclusive liquid crystal elastomers (LCEs), an important type actuators. Herein, a room‐temperature shape‐programmable LCE capable high‐energy actuation developed. Our approach utilizes hydrogen bonds to stabilize aligned...
Based on photoinduced S -nitrosylation and Schiff base reaction, a novel hydrogel fabrication strategy has been established to rapidly construct reinforced, biocompatible hydrogels for 3D printing related biomedical applications.