A5000452085- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Inflammatory mediators and NSAID effects
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Physiological and biochemical adaptations
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Eicosanoids and Hypertension Pharmacology
- Heart Failure Treatment and Management
- Neurobiology and Insect Physiology Research
- Cardiovascular Health and Risk Factors
- Fatty Acid Research and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cell Adhesion Molecules Research
- Medication Adherence and Compliance
- Anorectal Disease Treatments and Outcomes
- Acute Kidney Injury Research
- Cardiovascular Disease and Adiposity
- Natural Products and Biological Research
Peking University First Hospital
2016-2025
Peking University
2016-2025
Nanjing University of Chinese Medicine
2016-2025
Jiangsu Province Hospital
2024
South China Normal University
2013-2023
Chinese Medical Association
2020
Tianjin Medical University
2019
Translational Therapeutics (United States)
2019
University of Pennsylvania
2019
University of Chieti-Pescara
2019
Conventional fractional flow reserve (FFR) is measured invasively using a coronary guidewire equipped with pressure sensor. A non-invasive derived FFR would eliminate risk of injury, minimize technical limitations, and potentially increase adoption. We aimed to evaluate the diagnostic performance computational pressure-flow dynamics (caFFR), applied angiography, compared invasive FFR.The FLASH study was prospective, multicentre, single-arm conducted at six centres in China. Eligible patients...
A coronary angiography-derived index of microvascular resistance (caIMR) is proposed for physiological assessment microvasular diseases in circulation. The aim the study to assess diagnostic performance caIMR, using wire-derived (IMR) as reference standard. IMR was demonstrated 56 patients (57 vessels) with stable/unstable angina pectoris and no obstructive arteries three centers Certus pressure wire. Based on aortic wave angiograms from two projections, caIMR computed assessed blinded...
Vascular smooth muscle cell (VSMC) migration and proliferation are the hallmarks of restenosis pathogenesis after angioplasty. Cyclooxygenase (COX)-derived prostaglandin (PG) E₂ is implicated in vascular remodeling response to injury. However, its precise molecular role remains unknown.This study investigates impact COX-2-derived PGE₂ on neointima formation injury.Vascular was induced by wire injury femoral arteries mice. Both ratio were diminished COX-2 knockout mice as compared with...
Superficial temporal artery and middle cerebral (STA-MCA) bypass surgery is an effective method to enhance blood flow (CBF) in ischemic patients. However, the effectiveness of various techniques varies with diversity Circle Willis (CoW) structures. This study aims develop a physiologically realistic hemodynamic model optimize STA-MCA planning for ischemia patients different CoW developed 0D-1D geometric multi-scale haemodynamic that coupled stenosis autoregulation model. Based on this model,...
The association between sodium intake and mortality risk in the general population remains controversial. We aimed to explore all-cause a Chinese community-based population. A total of 6510 individuals from cohort were enrolled. 24-hour urinary excretion was estimated using Kawasaki formula. Cox proportional hazards models used determine spot with mortality. With mean follow-up 3.13 years, 65 participants (1.0%) experienced appeared be J-shaped (P for non-linearity = 0.009). Individuals...
An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. Here we have investigated the effects of RvE1 on recovery function MI in mice.Acute was induced by surgical ligation left anterior descending artery male C57BL/6 mice. (5 ng·g-1 ·day-1 ; i.p.) given to mice at different times following MI. Cardiac monitored transthoracic...
Background The adherence to secondary prevention treatment in patients with coronary heart disease (CHD) is low. Digital therapeutics (DTx) refers an emerging branch of medicine that delivers medical interventions directly using evidence-based, clinically evaluated, technology-based software algorithms or apps facilitate management, which may be efficient tool optimize adherence. Objective This paper aims investigate the effect mobile app–based self-management DTx on long-term use...
Mechanical insults, such as stent implantation, can induce endothelial injury, vascular inflammation, and ultimately lead to neointimal hyperplasia. Resolvin E1 (RvE1), derived from the ω3 fatty acid eicosa- pentaenoic acid, facilitate resolution of inflammation in many settings. We therefore aimed determine if there was a role for RvE1 preventing formation after arterial injury understand underlying mechanisms. Vascular hyperplasia were induced by wire femoral arteries mice. Administration...
Background Statins, being the primary pharmacological intervention for hypercholesterolemia, exhibit a notable degree of interpatient variability in their effectiveness, which may be associated with gut microbiota. This study sought to identify biomarkers evaluating differences statin efficacy. Methods A quasi case-control was conducted among participants hypercholesterolemia and coronary heart disease taking rosuvastatin essential. According level low density lipoprotein cholesterol...
Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous physiological and pathological processes including inflammation cardiovascular homeostasis. Each PG acts on its specific distinct cell surface G protein coupled receptors (GPCR) or peroxisome proliferator-activated (PPARs). Prostaglandin F2aphar receptor (FP) is required for female reproductive function such as luteolysis parturition. It has recently been implicated blood pressure regulation, atherosclerosis other...
Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many fail respond treatment. Dietary fish oil (FO), containing ω3 polyunsaturated fatty acids (PUFAs), has anti-inflammatory and cardio-protective properties, such as lowering cholesterol modulating platelet activity. The objective of the present study was investigate potential additional effects FO on activity vascular response injury.Femoral arterial remodelling...
Inflammatory bowel disease (IBD) is associated with an increased risk for thromboembolism, platelet activation, and abnormalities in number size. In colitis, platelets can extravasate into the colonic interstitium. We generated a mouse specific deletion of cyclooxygenase (COX)-1 megakaryocytes/platelets [(COX-1 conditional knockout (cKO)] to clarify role activation development inflammation fibrosis dextran sodium sulfate (DSS)–induced colitis. The activity index was assessed, specimens were...
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, with ischemic heart being a major contributor, either through coronary atherosclerotic plaque-related vascular or microvascular dysfunction.Obstruction blood flow impairs myocardial perfusion, which may lead to acute infarction in severe cases.The subendocardial viability ratio, also known as Buckberg index, is valuable tool for evaluation perfusion because it reflects balance between oxygen supply...
Abstracts Background Anorectal stricture is a severe and debilitating complication of Crohn's disease (CD). Currently, no specific patient-reported outcome measures (PROMs) exist to assess the severity anorectal or its impact on quality life among patients with CD. A new PROM scale has been developed measure CD stricture. Methods three-phase mixed-methods approach was implemented. Items were generated through literature review semi-structured interviews, followed by screening refinement via...
Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts >30 % of the world's population, imposing significant societal and familial burdens. Arterial stiffness is a known risk factor for various metabolic disorders, early-onset MASLD may be linked to heightened arterial stiffness. However, studies investigating link between are limited. This study utilized data from NHANES database, focusing on young adults aged 20 45 years, spanning 2005 2018. The Fatty Liver Index (FLI)...
Objective: To investigate the impact of coronary angiography-derived index microcirculatory resistance (caIMR) on long-term prognosis patients with heart disease (CHD) undergoing elective percutaneous intervention (PCI). Methods: The study was a retrospective cohort conducted at single centre. Patients who successfully underwent PCI pre-and post-PCI caIMR measurements in Peking University First Hospital between August 2013 and December 2020 were included. Then categorised into three groups...