A5089375803- Molecular Biology Techniques and Applications
- Dialysis and Renal Disease Management
- Forensic and Genetic Research
- Cancer Cells and Metastasis
- Neurological and metabolic disorders
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Plant Stress Responses and Tolerance
- Fungal Biology and Applications
- Research in Cotton Cultivation
- Renal and Vascular Pathologies
- Cardiac electrophysiology and arrhythmias
- Psychedelics and Drug Studies
- GABA and Rice Research
- Functional Brain Connectivity Studies
- Nanoplatforms for cancer theranostics
- Liver physiology and pathology
- Advanced MRI Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- MicroRNA in disease regulation
- Polyamine Metabolism and Applications
- Cardiovascular Disease and Adiposity
North China University of Science and Technology Affiliated Hospital
2025
National Yang Ming Chiao Tung University
2025
Nanjing Forestry University
2024
Jiangsu Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Tang Hospital
2022-2024
Jiangsu Normal University
2024
Capital Medical University
2020-2023
Soochow University
2018-2023
Shanxi Medical University
2022
Radiotherapy is a traditional method for cancer therapy but may become ineffective likely due to the radiation-induced immunosuppression. Instead of simply increasing radiation dose, reactivation immunosuppression in tumor microenvironment an alternative strategy successful treatment. In this work, we synthesized bismuth sulfide nanoparticles (BiNP) and conjugated with immunoactive Ganoderma lucidum polysaccharide (GLP). GLP-BiNP were able increase sensitivity radiotherapy, attributing...
Some wild cotton species are remarkably tolerant to salt stress, and hence represent valuable resources for improving tolerance of the domesticated allotetraploid Gossypium hirsutum L. Here, we first detected salt-induced stress changes in physiological biochemical indexes G. anomalum, a African diploid species. Under 350 mmol/L NaCl treatment, photosynthetic parameters declined significantly, whereas hydrogen peroxide (H2O2) malondialdehyde (MDA) contents increased. Catalase (CAT),...
The aim of this study was to construct and validate a new nomogram predict the risk poor outcome in patients with acute ischemic stroke (AIS) after intravenous thrombolytic therapy (IVT). A total 425 who received IVT within 4.5 h onset were included retrospective study. All divided into training (70%, n = 298) validation cohorts (30%, 127). Poor (defined as 90-day modified Rankin Scale score 3-5) primary outcome. Logistic regression used for analysis independent factors AIS. Nomograms AIS...
Radiotherapy was considered to induce an abscopal effect initiated through antigen release and presented by dendritic cells (DC), while the immunosuppressive tumor microenvironment (TEM) attenuated effects. Herein, we utilized bioactive polysaccharides extracted from natural herb Astragalus membranaceus developed polysaccharide nanoparticles (ANPs) that can reverse TEM and, accordingly, enhance radiation-induced effect. ANP showed ability prolong survival rate of tumor-bearing mice. In...
Drought stress is a key limiting factor for cotton (Gossypium spp.) growth, production, development, and production worldwide. Some wild diploid species are remarkably tolerant of water deficit constitute an important reservoir understanding the molecular mechanisms Gossypium spp. drought tolerance improving cultivated upland cotton. Here, we utilized RNA-Seq technology to characterize leaf transcriptomes African species, anomalum, under stress. A total 12,322 differentially expressed genes...
Aim: To investigate the immune responses and antitumor efficacy of immunoactive polysaccharide functionalized gold nanocomposites (APS-AuNP). Materials & methods: Immunoregulation APS-AuNP on dendritic cells/T cells in vitro was evaluated by flow cytometry their inhibitions against primary/metastatic tumors were determined 4T1-bearing mice model. Results conclusion: exhibited remarkable capability to induce maturation through phenotypic markers with functional changes, which further promoted...
Objectives: To investigate the subclinical imaging changes in terms of myocardial inflammation and fibrosis to explore risk factors associated with by cardiac magnetic resonance (CMR) approach a Chinese HIV/AIDS cohort. Methods: We evaluated function (cine), (T1, T2), (through extracellular volume fraction [ECV] late gadolinium enhancement [LGE]) multiparametric CMR scan protocol total 68 participants, including 47 HIV-infected individuals, who were divided into two groups: asymptomatic HIV...
Ubiquitin-specific processing enzyme 22 (USP22) plays a direct role in regulating cell cycle, and its overexpression has been reported to be involved tumor progression. However, little is known about the regulation of USP22 transcription. In this study, we cloned characterized human promoter. Using 5' RACE (rapid amplification cDNA ends) analysis, transcriptional initiation site was identified. Promoter deletion analysis showed that sequence between -210 -7 contains basal promoter for...
Abstract Albumin-biomineralized copper sulfide nanoparticles (Cu 2−x S NPs) have attracted much attention as an emerging phototheranostic agent due to their advantages of facile preparation method and high biocompatibility. However, comprehensive preclinical safety evaluation is the only way meet its further clinical translation. We herein evaluate detailedly hepatotoxicity bovine serum albumin-biomineralized Cu (BSA@Cu S) NPs with two different sizes in rats. Large-sized (LNPs, 17.8 nm)...
Abstract Objective To compare the effects of peritoneal dialysis and hemodialysis on spontaneous brain activity in patients with end-stage renal disease. Methods A total 52 disease, including 25 chronic kidney disease undergoing (HD-CKD) 27 (PD-CKD), 49 healthy controls (normal control) were included. All participants underwent neuropsychological testing (Mini-Mental State Examination Montreal cognitive assessment) resting-state functional magnetic resonance imaging. Fractional amplitude low...
The study characterizes regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in abnormal regions brain patients chronic kidney disease (CKD).A total 64 CKD were divided into 26 cases non-dialysis-dependent (NDD-CKD), 38 dialysis-dependent (DD-CKD). A 43 healthy controls (normal control, NC) also included. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). ALFF ReHo data was processed for monitoring the differences spontaneous...
Aim: To explore the hepatotoxicity of copper sulfide nanoparticles (CuSNPs) toward hepatocyte spheroids. Materials & methods: Other than traditional agarose method to generate spheroids, we developed a multi-concave chip (MCAC) investigate changes in viability, morphology, mitochondrial membrane potential, reactive oxygen species and hepatobiliary transporter by CuSNPs. Results: The MCAC allowed large number spheroids be obtained per sample. CuSNPs showed vitro through decrease spheroid...
Abstract This paper describes the development and validation of a novel 31‐locus, six‐dye STR multiplex system, which is designed to meet needs rapidly growing Chinese forensic database. new assay combines 20 extended‐CODIS core loci (D3S1358, D5S818, TPOX, CSF1PO, TH01, vWA, D7S820, D21S11, D8S1179, D18S51, D16S539, D13S317, FGA, D1S1656, D2S441, D2S1338, D10S1248, D12S391, D19S433, D22S1045), nine highly polymorphic in Han population (D3S3045, D6S1043, D6S477, D8S1132, D10S1435, D15S659,...
With hepatocellular carcinoma (HCC) becoming a heavy disease burden in China, it is particular to reveal its pathological mechanism. Recent researches have indicated that small nucleolar RNAs (snoRNAs) may be involved various cancers including HCC. Polymorphisms within snoRNAs affect function or expression level, and even host gene, then produce series of effects related itself gene.The association the single nucleotide polymorphism (SNP) rs2305789 SNORD105 with HCC susceptibility was...
In individuals with chronic kidney disease (CKD), neurological damage is commonly observed. This neurodegeneration closely linked to microstructural the brain white matter due high incidence of cognitive dysfunction. However, specific pathogenesis CKD nephropathy caused by system developmental disorders remains unclear. study aimed examine correlation between impairment and diffusion parameters obtained on tensor imaging (DTI) abnormal tracts in patients.Sixty-four patients were divided into...
In recent years, trafficking and abuse of hallucinogenic mushrooms have become a serious social problem. It is therefore imperative to identify the genus Psilocybe for national drug control legislation. An internal transcribed spacer (ITS) DNA barcoding tool utilized species identification. Many methods been used discriminate ITS region, but they are often limited by having low resolution. this study, we sought analyze its fragments, ITS1 ITS2, using high-resolution melting (HRM) analysis,...