A5044707901- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Environmental DNA in Biodiversity Studies
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Forensic Anthropology and Bioarchaeology Studies
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Genomic variations and chromosomal abnormalities
- RNA and protein synthesis mechanisms
- Cardiac electrophysiology and arrhythmias
- Genetic Syndromes and Imprinting
- Gene expression and cancer classification
- Race, Genetics, and Society
- Yersinia bacterium, plague, ectoparasites research
- Gut microbiota and health
Institute of Forensic Science
2016-2025
Shanghai Medical College of Fudan University
2020-2025
Fudan University
2008-2025
Wenzhou Medical University
2017-2024
Shanxi Medical University
2023-2024
Shaanxi University of Science and Technology
2021-2024
Shanghai Public Security Bureau
2024
Hainan University
2023
Soochow University
2018-2023
Southern Medical University
2020-2023
Abstract Illuminating interactions between proteins and small drug molecules is a longstanding challenge in the field of discovery. Despite importance understanding these interactions, most previous works are limited by hand-designed scoring functions insufficient conformation sampling. The recently-proposed graph neural network-based methods provides alternatives to predict protein-ligand complex one-shot manner. However, neglect geometric constraints structure weaken role local functional...
Abstract The complete biosynthetic pathways are unknown for most natural products (NPs), it is thus valuable to make computer-aided bio-retrosynthesis predictions. Here, a navigable and user-friendly toolkit, BioNavi-NP, developed predict the both NPs NP-like compounds. First, single-step prediction model trained using general organic reactions through end-to-end transformer neural networks. Based on this model, plausible can be efficiently sampled an AND-OR tree-based planning algorithm...
While significant advances have been made in predicting static protein structures, the inherent dynamics of proteins, modulated by ligands, are crucial for understanding function and facilitating drug discovery. Traditional docking methods, frequently used studying protein-ligand interactions, typically treat proteins as rigid. molecular simulations can propose appropriate conformations, they're computationally demanding due to rare transitions between biologically relevant equilibrium...
The growth arrest special 5 (GAS5) is known to be involved in various cancers. However, its expression regulation remains unclear. Polymorphisms the promoter region of GAS5 may affect and associated with cancer susceptibility. In this research, we first evaluated association a 5-base pair indel polymorphism (rs145204276) hepatocelluar carcinoma (HCC) susceptibility Chinese populations. Logistic regression analysis showed that deletion allele rs145204276 significantly increased risk HCC two...
Rationale: PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1α) represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate expression as a therapy, for instance, causing cardiomyopathy. Objective: To determine whether fine-tuning of is essential cardiac homeostasis in context-dependent manner. Methods Results: Moderate cardiac-specific overexpression through ROSA26 locus knock-in strategy was...
The archaea Sulfolobus utilizes the ESCRT-III-based machinery for cell division. This comprises three proteins: CdvA, Eukaryotic-like ESCRT-III and Vps4. In addition to ESCRT-III, cells also encode other homologs termed ESCRT-III-1, -2 -3. Herein, we show that ESCRT-III-1 in S. islandicus REY15A are localized at midcell between segregating chromosomes, indicating both involved Genetic analysis reveals escrt-III-2 is indispensable viability with reduced overall level of exhibit growth...
The skin microbiome plays a pivotal role in human health by providing protective and functional benefits. Furthermore, its inherent stability individual specificity present novel forensic applications. These aspects have sparked considerable research enthusiasm among scholars across various fields. However, the selection of specific 16S rRNA hypervariable regions for studies is not standardized should be validated through extensive tailored to different objectives targeted bacterial taxa....
ABSTRACT The human skin and oral cavity harbor complex microbial communities, which exist in dynamic equilibrium with the host's physiological state external environment. This study investigates atlas of cavities using samples collected over a 10‐month period, aiming to assess how both internal factors influence microbiome. We examined bacterial community diversity stability across various body sites, including palm nasal skin, saliva, epithelial cells, during environmental changes COVID‐19...
Abstract The dysregulation of YAP activity is implicated in abnormal organ size and the pathogenesis diverse diseases, including cancer. However, functional regulation by lncRNA-encoded peptides remains elusive. In this study, we report identification a small protein (93 aa) encoded lncRNA LINC01315. This protein, termed YAPer-ORF, preferentially interacted with GNAQ/11 mutants to augment activity. Mechanistically, YAPer-ORF was located nucleus competed bind nuclear kinase PRP4K hinder...
Major depressive disorder (MDD) is a complex psychiatric illness, with synaptic plasticity playing key role in its pathology. Our study aims to investigate the molecular basis of MDD by analyzing plasticity-related gene expression at single-cell level. Utilizing published snRNA-seq dataset (GSE144136), we identified Excitatory.neurons_1 as cell cluster most associated and through clustering, set enrichment analysis (GSEA), pseudotime analysis. Integrating bulk RNA-seq data (GSE38206),...
Abstract STRs, scattered throughout the genome with higher mutation rate, are attractive to genetic application like forensic, anthropological and population genetics studies. STR profiling has now been applied in various aspects of human identification forensic investigations. This work described developmental validation a novel universal assay, Huaxia Platinum System, which amplifies all markers expanded CODIS core loci Chinese National Database one single PCR system. Developmental...