A5005108586- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- European history and politics
- Autophagy in Disease and Therapy
- German History and Society
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Redox biology and oxidative stress
- Nanoplatforms for cancer theranostics
- bioluminescence and chemiluminescence research
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Biotin and Related Studies
- Advanced Fluorescence Microscopy Techniques
- German legal, social, and political studies
- Historical Geopolitical and Social Dynamics
Sun Yat-sen University
2024-2025
East China University of Science and Technology
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Chinese Academy of Sciences
2020-2022
Shanghai Institutes for Biological Sciences
2020-2022
Fudan University
2022
Shanghai Jiao Tong University
2022
Binzhou University
2022
Binzhou Medical University
2022
Humboldt State University
2019
Autophagy and glycolysis are highly conserved biological processes involved in both physiological pathological cellular programs, but the interplay between these is poorly understood. Here, we show that glycolytic enzyme lactate dehydrogenase A (LDHA) activated upon UNC-51-like kinase 1 (ULK1) activation under nutrient deprivation. Specifically, ULK1 directly interacts with LDHA, phosphorylates serine-196 when nutrients scarce promotes production. Lactate connects autophagy through Vps34...
Abstract Senescent cells remain metabolically active, but their metabolic landscape and resulting implications underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. display a PDK4-dependent increase aerobic glycolysis enhanced lactate production maintain mitochondrial respiration redox activity, thus adopting special form reprogramming. Medium from PDK4 + promotes the malignancy recipient cancer vitro,...
Rationale: PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1α) represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate expression as a therapy, for instance, causing cardiomyopathy. Objective: To determine whether fine-tuning of is essential cardiac homeostasis in context-dependent manner. Methods Results: Moderate cardiac-specific overexpression through ROSA26 locus knock-in strategy was...
How particular bone marrow niche factors contribute to the leukemogenic activities of leukemia-initiating cells (LICs) remains largely unknown. Here, we showed that ATP levels were markedly increased in niches mice with acute myeloid leukemia (AML), and LICs preferentially localized endosteal relatively high levels, as indicated by a sensitive indicator. could efficiently induce influx ions into an MLL-AF9–induced murine AML model via ligand-gated ion channel P2X7. P2x7 deletion led notably...
Rewiring of redox metabolism has a profound impact on tumor development, but how the cellular heterogeneity balance affects leukemogenesis remains unknown. To precisely characterize dynamic change in vivo, we developed bright genetically encoded biosensor for H 2 O (named HyPerion) and tracked state leukemic cells situ transgenic sensor mouse. A -low (HyPerion-low) subset acute myeloid leukemia (AML) was enriched with leukemia-initiating cells, which were endowed high colony-forming ability,...
Christa Wolf’s short story ‘Selbstversuch’ depicts how the protagonist goes through a sex-change transformation from female to male and, in liminal status, reflects upon various social expectations of different genders. In this way, Wolf explores gender issues East Germany, which her earlier novels, such as Der geteilte Himmel (1963) and Nachdenken über T. (1968), was already major theme later demonstrates itself more sophisticated way other novels. This article examines lens liminality...
Abstract High-resolution spatiotemporal imaging of histidine in single living mammalian cells faces technical challenges. Here, we developed a series ratiometric, highly responsive, and fluorescent protein-based sensors wide dynamic range. We used these to quantify subcellular free-histidine concentrations glucose-deprived glucose-fed cells. Results showed that cytosolic concentration was higher more sensitive the environment than free mitochondria. Moreover, readily transported across...