Xianjun Chen

ORCID: 0000-0002-8475-332X
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About
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Research Areas
  • RNA and protein synthesis mechanisms
  • Photoreceptor and optogenetics research
  • Photosynthetic Processes and Mechanisms
  • Light effects on plants
  • Advanced biosensing and bioanalysis techniques
  • Plant Stress Responses and Tolerance
  • CRISPR and Genetic Engineering
  • Epigenetics and DNA Methylation
  • bioluminescence and chemiluminescence research
  • Genetics and Neurodevelopmental Disorders
  • Electrocatalysts for Energy Conversion
  • Advanced Fluorescence Microscopy Techniques
  • Nanoplatforms for cancer theranostics
  • RNA Research and Splicing
  • Antibiotic Resistance in Bacteria
  • Cancer Research and Treatments
  • Bacteriophages and microbial interactions
  • Face and Expression Recognition
  • Immune cells in cancer
  • Computer Graphics and Visualization Techniques
  • Bone Tissue Engineering Materials
  • Remote-Sensing Image Classification
  • Respiratory Support and Mechanisms
  • CAR-T cell therapy research
  • Image Retrieval and Classification Techniques

East China University of Science and Technology
2016-2025

Ningbo No. 2 Hospital
2017-2025

Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025

Kaili University
2024-2025

Dalian University of Technology
2025

Shihezi University
2017-2024

Guiyang Medical University
2016-2024

Huzhou Vocational and Technical College
2023-2024

Ningbo No.6 Hospital
2023-2024

Affiliated Hospital of Guizhou Medical University
2016-2024

Abstract Circular RNAs (circRNAs) have emerged as crucial regulators of human cancers. Glutaminolysis supplies cancer cells with adequate nitrogen and carbon to replenish the tricarboxylic acid cycle, contributing survival progression tumor cells. However, association between circRNAs glutaminolysis remains unclear. In this study, we showed that circHECTD1 expression was markedly upregulated in gastric (GC) associated lymph node metastasis American Joint Committee on Cancer stage. The level...

10.1038/s41419-019-1814-8 article EN cc-by Cell Death and Disease 2019-08-01

Colorectal cancer (CRC) is a type of with mortality rate among the highest worldwide owing to its high metastasis. Therefore, inflammation-associated metastasis in development CRC currently topic considerable interest. In present study, pro-inflammatory cytokine interleukin-4 (IL-4) was identified promote epithelial-mesenchymal transition (EMT) cells. However, enhancing effect IL-4 more evident HCT116 cells compared RKO Accordingly, an increased expression level STAT6 observed Further...

10.3892/ijo.2018.4429 article EN cc-by-nc-nd International Journal of Oncology 2018-06-05

Abstract Light-regulated modules offer unprecedented new ways to control cellular behaviour with precise spatial and temporal resolution. Among a variety of bacterial light-switchable gene expression systems, single-component systems consisting single transcription factors would be more useful due the advantages speed, simplicity, versatility. In present study, we developed light-activated system (eLightOn) based on novel LOV domain from Rhodobacter sphaeroides (RsLOV). The eLightOn showed...

10.1093/nar/gkaa044 article EN cc-by-nc Nucleic Acids Research 2020-01-16

In this study, the protective role of exogenous ascorbic acid (AsA) on salt-induced inhibition photosynthesis in seedlings processing tomatoes under salt stress has been investigated. Plants (NaCl, 100 mmol/L) were foliar-sprayed with AsA (0.5 mmol/L), lycorine (LYC, 0.25 mmol/L, an inhibitor key synthesis enzyme l -galactono-γ-lactone dehydrogenase activity), or plus LYC. The effects fast OJIP fluorescence rise curve and JIP parameters then examined. Our results demonstrated that applying...

10.3389/fpls.2021.594400 article EN cc-by Frontiers in Plant Science 2021-08-16

Abstract Although the link of white matter to pathophysiology schizophrenia is documented, loss myelin not detected in patients at early stages disease, suggesting that pathological evolution may occur before significant loss. Disrupted-in-schizophrenia-1 (DISC1) protein highly expressed oligodendrocyte precursor cells (OPCs) and regulates their maturation. Recently, DISC1-Δ3, a major DISC1 variant lacks exon 3, has been identified patients, although its significance remains unknown. In this...

10.1038/s41380-022-01777-3 article EN cc-by Molecular Psychiatry 2022-09-21

Web service has been an industry standard tech for message communication and integration between heterogeneous systems. RESTFUL API become mainstream web development paradigm after SOAP, how to effectively construct remains a research hotspots. This paper presents model of construction based on PHP language LARAVEL framework. The key technical problems that need be solved during the are discussed, implementation details given.

10.1088/1742-6596/910/1/012016 article EN Journal of Physics Conference Series 2017-10-01

With the development of minimally invasive orthopedics, injectable materials for bone repair are attracted more attention, especially those wound with a small external mouth and sizeable internal cavity. In this work, hydrogel features thermo-responsiveness, degradability injectability was designed fabricated. The hydrogel, named as FHCS, is composed Pluronic F-127 (F127) loaded carboxymethyl chitosan/sodium alginate nanoparticles (nCS) nanohydroxyapatite (nHA). FHCS non-toxic good...

10.1016/j.ijbiomac.2022.10.142 article EN cc-by International Journal of Biological Macromolecules 2022-10-18

Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular and sensing events. Here, we chemically evolved self-labeling SNAP-tag into a palette of mimics (SmFPs) that possess bright, rapidly inducible fluorescence ranging from cyan to infrared. SmFPs integral chemical-genetic entities based on same fluorogenic principle as FPs, i.e., induction non-emitting molecular rotors by conformational locking. We demonstrate usefulness these in real-time...

10.1038/s41421-023-00546-y article EN cc-by Cell Discovery 2023-06-13

Evidence indicated that the early stage transition of macrophages' polarization stages yielded a superior prognosis for acute lung injury (ALI) or respiratory distress syndrome (ARDS). Rhein (cassic acid) is one major component many traditional Chinese medicines, and has been reported to perform with strong anti-inflammation capabilities. However, role rhein played mechanism via which it did so in LPS-induced ALI/ARDS remain unclear.ALI/ARDS was induced by LPS (3 mg/kg, i.n, st), accompanied...

10.1007/s00011-023-01746-8 article EN cc-by Inflammation Research 2023-05-22

Abstract Purpose The purpose of this study was to investigate the risk factors for umbilical artery thrombosis (UAT) and relationship between perinatal outcomes. Methods This a retrospective that enrolled singleton pregnant women who were diagnosed with thrombosis. control group recruited woman three vessels or those isolated single (iSUA) matched group. outcomes compared groups. Results Preconception BMI (OR [95%CI]: 1.212 [1.038–1.416]), abnormal cord insertion 16.695 [1.333-209.177])...

10.1186/s12884-024-06335-z article EN cc-by BMC Pregnancy and Childbirth 2024-02-14
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