A5101633610- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Adenosine and Purinergic Signaling
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- RNA Research and Splicing
- RNA regulation and disease
- Cardiac electrophysiology and arrhythmias
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Phylogenetic Studies
- Soil Carbon and Nitrogen Dynamics
- Nerve injury and regeneration
- Soybean genetics and cultivation
- Circular RNAs in diseases
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Stroke Rehabilitation and Recovery
- Inflammatory Biomarkers in Disease Prognosis
- Genetic Neurodegenerative Diseases
- Cancer-related Molecular Pathways
- Kruppel-like factors research
Dalian Medical University
2012-2025
First Affiliated Hospital of Dalian Medical University
2010-2025
First Affiliated Hospital of Xinxiang Medical University
2025
Xinxiang Medical University
2025
Nanjing Drum Tower Hospital
2020-2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Nanjing University
2023-2025
Harbin Institute of Technology
2023-2024
Heilongjiang University
2022-2024
Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability the blood-brain barrier. A comprehensive understanding underlying mechanism that allows cells to infiltrate is necessary circumvent treatment resistance BCBMs. Here, we determined expression a long noncoding RNA (lncRNA) named lncRNA associated with BCBM (Lnc-BM) prognostic progression metastasis in patients. In preclinical murine models, elevated...
Abstract Cancer-testis ( CT ) genes represent the similarity between processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern can help identify driver in cancer. In this study, we integrate transcriptomics data from multiple databases systematically 876 new 19 cancer types. We explore relationship with testis-specific regulatory elements. propose extremely highly expressed (EECTGs) are potential drivers activated through epigenetic mechanisms....
Long non-protein-coding RNAs (lncRNAs) are involved in the pathological processes of nervous system diseases. NONRATT021972 is an lncRNA. This study explores effects lncRNA small interference RNA (siRNA) on diabetic neuropathic pain (DNP) mediated by P2X7 receptor rat dorsal root ganglia (DRG). Our results show that expression was significantly higher DRG diabetes mellitus (DM) group compared with control group. reduced when DM rats were treated siRNA. siRNA treatment type 2 increased...
The growth arrest special 5 (GAS5) is known to be involved in various cancers. However, its expression regulation remains unclear. Polymorphisms the promoter region of GAS5 may affect and associated with cancer susceptibility. In this research, we first evaluated association a 5-base pair indel polymorphism (rs145204276) hepatocelluar carcinoma (HCC) susceptibility Chinese populations. Logistic regression analysis showed that deletion allele rs145204276 significantly increased risk HCC two...
To investigate the expression pattern and significance of DNA repair genes JWA X-ray cross complement group 1 (XRCC1) in gastric cancer.Expressions XRCC1 were assessed by immunohistochemistry a training cohort they went into second testing finally to validating cohort. Prognostic predictive role status cases treated with surgery alone or combined adjuvant chemotherapy was evaluated, respectively.JWA protein levels significantly downregulated cancer lesions compared adjacent noncancerous...
Rationale: Abnormal metabolic states contribute to a variety of diseases, including cancer. RNA modifications have diverse biological functions and are implicated in cancer development, gastric (GC). However, the direct relationship between glucose homeostasis 4-acetylcytosine (ac4C) modification GC remains unclear. Methods: The prognostic value acetyltransferase NAT10 expression was evaluated human cohort. Additionally, preoperative PET/CT data from patients Micro-PET/CT imaging mice were...
Abstract Background fatty acids are considered to be effective components promote wound healing and Lucilia sericata larvae applied clinically treat intractable wounds. We aimed investigat the effect of acid extracts from dried on murine cutaneuous as well angiogenesis. Results On day 7 10 after acute excision wounds creation, percent contraction group was higher than that vaseline group. 3, quality better terms granulation formation collagen organization. 3 micro vessel density vascular...
Abstract Long noncoding RNA (lncRNA) is yet to be linked cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA associated with cytosolic cyclin-dependent kinase CDK6 regulated CDK6-dependent phosphorylation fructose bisphosphatase PFK2 (PFKFB3) a cell-cycle–independent manner. In cells, these events promoted catalysis glucose 6-phosphate...
Abstract Although the link of white matter to pathophysiology schizophrenia is documented, loss myelin not detected in patients at early stages disease, suggesting that pathological evolution may occur before significant loss. Disrupted-in-schizophrenia-1 (DISC1) protein highly expressed oligodendrocyte precursor cells (OPCs) and regulates their maturation. Recently, DISC1-Δ3, a major DISC1 variant lacks exon 3, has been identified patients, although its significance remains unknown. In this...
Abstract The CRISPR-Cas system is a highly adaptive and RNA-guided immune found in bacteria archaea, which has applications as genome editing tool valuable for studying the co-evolutionary dynamics of bacteriophage interactions. Here introduces CRISPRimmunity, new web server designed Acr prediction, identification novel class 2 loci, dissection key CRISPR-associated molecular events. CRISPRimmunity built on suite CRISPR-oriented databases providing comprehensive perspective anti-CRISPR...
Abstract Background Gastric cancer (GC) is one of the most common tumours in East Asia countries and associated with Helicobacter pylori infection. H. utilizes virulence factors, CagA VacA, to up‐regulate pro‐inflammatory cytokines activate NF‐κB signaling. Meanwhile, PIEZO1 upregulation cancer‐associated fibroblast (CAF) enrichment were found GC progression. However, mechanisms its involvement progression have not been fully elucidated. Methods The CAF clinical significance investigated...
Objective: To evaluate the bio‐debridement effect of maggot therapy for treating chronically infected lesions. Methods: A retrospective study was conducted 25 patients with diabetic foot ulcers and 18 pressure after spinal cord injury treated by or traditional dressing. Changes in lesions were observed bacterial cultures tested. Results: All healed completely. The times taken to achieve negativity, granulation healing all significantly shorter group than control group, both ( P < 0.05)...
Although EZH2 enzymatic inhibitors have shown antitumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because can promote cancer independently of its histone methyltransferase activity. Here we identify ZRANB1 as the deubiquitinase. binds, deubiquitinates, stabilizes EZH2. Depletion breast cells results destabilization growth inhibition. Systemic delivery small interfering RNA (siRNA) leads to marked antimetastatic preclinical models...
Abstract CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies. Using bioinformatics analysis biochemical experiments, here we present a new family RNA-guided DNA endonucleases. Our initially identifies stable co-occurrence conserved RAGATH-18-derived RNAs (reRNAs) their upstream IS607 with an average length 390 amino acids. form programmable DNases through interaction reRNAs. We discover robust dsDNA interference...
Patients with the most common advanced human cancers such as lung, breast, uterus, and of digestive system almost always develop bone metastases, painful untreatable consequences. This study aimed to determine prognostic implications neutrophil/lymphocyte (N/L) ratio in peripheral blood patients malignant metastasis. Study participants were identified from a prospective cohort cancer Data for N/L ratios obtained clinical pathological records analyzed together other known factors multivariate...
Objectives: DFU is a serious chronic disease with high disability and fatality rates, yet there no completely effective therapy. While ferroptosis integrated to inflammation infection, its involvement in still unclear. The study aimed identify ferroptosis-related genes DFU, providing potential therapeutic targets. Methods: In the GEO database, two microarray datasets (GSE147890 GSE80178) were collected. WGCNA was conducted modular most involved DFU. Subsequently, enrichment analysis PPI...
Abstract Homeobox genes include HOX and non ‐HOX genes. proteins play fundamental roles during ontogenesis by interacting with other non‐ gene‐encoded partners performing transcriptional functions, whereas aberrant activation of family members drives tumorigenesis. In this study, gastric cancer (GC) expression microarray data indicated that HOXB9 is a prominent upregulated member in GC samples significantly associated clinical outcomes advanced TNM stages. However, the functional role...
ABSTRACT Background Gastric cancer (GC) is a major health concern worldwide. One important contributing factor the presence of Epstein‐Barr virus (EBV). However, molecular pattern how EBV participates in malignant transition process remains unclear. Methods GC samples were stained by immunohistochemistry, fluorescent and EBV‐encoded small RNA situ hybridization to identify CD8 expression, CDKN2A genomic alteration, existence. Functional potentials infection predicted bioinformatic enrichment...
The prognostic role of preoperative inflammation-nutrition-related markers in locally advanced lip squamous cell carcinoma (LSCC) remains underexplored. This study aimed to assess the impact various on prognosis patients with LSCC undergoing surgical treatment and establish a corresponding predictive model. A retrospective analysis was performed clinical data 169 who underwent treatment. total 27 clinicopathological variables, including markers, were collected. Univariate multivariate Cox...
Sudden unexplained death (SUD) refers to sudden in which the cause of could not be established after a comprehensive medico-legal investigation, including pathological/toxicological assessment and forensic investigation circumstances death. In past decade, molecular autopsy has proved an efficient diagnostic tool multidisciplinary management SUD. Though numerous pathogenic/likely pathogenic (P/LP) variants have been identified, there is still large proportion SUD cases without clear...